The Real Herg
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Real World Drug Discovery
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Author : Robert M. Rydzewski
language : en
Publisher: Elsevier
Release Date : 2010-07-07
Real World Drug Discovery written by Robert M. Rydzewski and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-07 with Medical categories.
Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.
Dynamic Clamp
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Author : Alain Destexhe
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-11
Dynamic Clamp written by Alain Destexhe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-11 with Medical categories.
Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called “conductance injection”) allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons. This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.
Artificial Intelligence In Heart Modelling
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Author : Rafael Sebastian
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-11
Artificial Intelligence In Heart Modelling written by Rafael Sebastian and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-11 with Science categories.
Stem Cells From Hype To Real Hope
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Author : Khawaja Husnain Haider
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2018-12-17
Stem Cells From Hype To Real Hope written by Khawaja Husnain Haider and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-17 with Medical categories.
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.
The Real Herg
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Author : Sian Lye
language : en
Publisher: White Owl
Release Date : 2020-12-28
The Real Herg written by Sian Lye and has been published by White Owl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-28 with Comics & Graphic Novels categories.
“If you are looking to understand a bit more about the circumstances that inspired The Adventures of Tintin—this book will provide a good snapshot.” —The BookBuff Review Hergé created only twenty-four Tintin books which have been translated into more than seventy languages and sold 230 million copies worldwide. The Real Hergé: The Inspiration Behind Tintin takes an in-depth look at the man behind the cultural phenomenon and the history that helped shape these books. As well as focusing on the controversies that engulfed Hergé, this biography will also look at his personal life, as well as the relationships and experiences that influenced him. “Tintin is more famous now than when Hergé was actually writing and illustrating his adventures. Sian Mye’s book is another in the excellent series about the real lives of our most famous authors, and is well worth a look. Brilliant!” —Books Monthly “It is certainly possible to enjoy the Tintin books without knowing Hergé. But they are more interesting after learning about this complex, sometimes frustrating, man. We can learn from him, even if we learn from his mistakes.” —Rose City Reader
Principles Of Translational Science In Medicine
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Author : Martin Wehling
language : en
Publisher: Academic Press
Release Date : 2015-04-02
Principles Of Translational Science In Medicine written by Martin Wehling and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-02 with Science categories.
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions
Cardiac Modeling Aiming For Optimization Of Therapy
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Author : Javier Saiz
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-15
Cardiac Modeling Aiming For Optimization Of Therapy written by Javier Saiz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-15 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Predictive Toxicology In Drug Safety
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Author : Jinghai J. Xu
language : en
Publisher: Cambridge University Press
Release Date : 2010-09-27
Predictive Toxicology In Drug Safety written by Jinghai J. Xu and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-27 with Medical categories.
According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body.
Potassium Channels In Cardiovascular Biology
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Author : Stephen L. Archer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Potassium Channels In Cardiovascular Biology written by Stephen L. Archer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.
Molecular Genetics Of Cardiac Electrophysiology
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Author : C. Berul
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Genetics Of Cardiac Electrophysiology written by C. Berul and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.