The Retinoids V 2
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The Retinoids V 2
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Author : BAERT ET BAERT ET AL
language : en
Publisher: Academic Press
Release Date : 2014-06-28
The Retinoids V 2 written by BAERT ET BAERT ET AL and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Medical categories.
The Retinoids: v. 2
The Retinoids
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Author : Pascal Dollé
language : en
Publisher: John Wiley & Sons
Release Date : 2015-05-18
The Retinoids written by Pascal Dollé and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-18 with Science categories.
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
The Biochemistry Of Retinoid Signaling Ii
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Author : Mary Ann Asson-Batres
language : en
Publisher: Springer
Release Date : 2016-11-09
The Biochemistry Of Retinoid Signaling Ii written by Mary Ann Asson-Batres and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-09 with Medical categories.
The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
The Retinoids
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Author : Michael B. Sporn
language : en
Publisher: Academic Press
Release Date : 2012-12-02
The Retinoids written by Michael B. Sporn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.
The Retinoids
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Author : Pascal Dollé
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-13
The Retinoids written by Pascal Dollé and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-13 with Science categories.
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Retinoids And Carotenoids In Dermatology
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Author : Anders Vahlquist
language : en
Publisher: CRC Press
Release Date : 2007-06-20
Retinoids And Carotenoids In Dermatology written by Anders Vahlquist and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-20 with Medical categories.
This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of
Vitamin A And Retinoids An Update Of Biological Aspects And Clinical Applications
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Author : Maria A. Livrea
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Vitamin A And Retinoids An Update Of Biological Aspects And Clinical Applications written by Maria A. Livrea and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.
Retinoids
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Author : Maria A Livrea
language : en
Publisher: CRC Press
Release Date : 1993-01-18
Retinoids written by Maria A Livrea and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-18 with Science categories.
This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications, held in 1991 in Palermo, Italy, describing the latest research findings on biochemistry, nutrition, molecular and cell biology and developmental biology, as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by leading authorities in the field from the USA, Europe and Japan, Retinoids, amongst other things: addresses retinol-supported retinoic acid (RA) synthesis and catabolism; identifies synthetic ligands with a high selective affinity for RAR-alpha, -beta and -gamma nuclear receptors, determining if they would show pharmacological properties similar to the natural parent substance all-trans RA; considers the embryonic/foetal cellular retinoid-binding proteins and evidence for their participation in normal and abnormal morphogenesis; discusses a novel arotinoid, Ro 40-8757, that exhibited improved anti-tumour efficacy and safety in pre-clinical tests; and reports the audioradiographic distribution of retinol and RA in organs of pregnant hamsters and foetuses.
The Retinoids V 2
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Author : Michael B. Sporn
language : en
Publisher: Academic Press
Release Date : 1984-04-28
The Retinoids V 2 written by Michael B. Sporn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-04-28 with Medical categories.
Abstract: A 2-volume treatise for scientists and clinicians contains 19 authoritative overview articles by experts in their respective fields, represents the first comprehensive survey of the chemistry and biology of the retinoids. The 2-volume set begins with the basic chemistry concepts of the retinoids (including vitamin A) and their analogs, and progresses towards biological aspects, and then to clinical considerations. Volume 1 deals with new advances in organic and trace chemistry, chemical and biological methods of retinoid analysis and a comprehensive survey of vitamin A in human and animal nutrition. Volume 2 reviews the biochemistry and metabolism of retinoids and retinoid bindingproteins; cellular and molecular mechanisms of action of the retinoids; toxicological, teratological, and immunological aspects; and the applications of retinoids to cancer and dermatology. Chemical structures of the retinoids are appended.(wz).
Retinoids
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Author : C.E. Orfanos
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Retinoids written by C.E. Orfanos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.