The Role Of Calcitonin Gene Related Peptide In Peripheral And Central Pain Mechanisms Including Migraine
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The Role Of Calcitonin Gene Related Peptide In Peripheral And Central Pain Mechanisms Including Migraine
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Author :
language : en
Publisher:
Release Date : 2017
The Role Of Calcitonin Gene Related Peptide In Peripheral And Central Pain Mechanisms Including Migraine written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Calcitonin Gene Related Peptide Cgrp Mechanisms
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Author : Susan D. Brain
language : en
Publisher: Springer Nature
Release Date : 2019-08-31
Calcitonin Gene Related Peptide Cgrp Mechanisms written by Susan D. Brain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.
From Basic Pain Mechanisms To Headache
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Author : Jes Olesen
language : en
Publisher: Frontiers in Headache Research
Release Date : 2006
From Basic Pain Mechanisms To Headache written by Jes Olesen and has been published by Frontiers in Headache Research this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Health & Fitness categories.
Though the topics of pain and headache are obviously linked, these two research fields have in recent years developed at their own pace, often with scant attention paid to the other. This book brings together researchers and clincians from the forefront of these two disciplines to explore how the basic pain mechanisms relate to migraine and other forms of headache.
Neurobiological Basis Of Migraine
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Author : Turgay Dalkara
language : en
Publisher: John Wiley & Sons
Release Date : 2017-08-07
Neurobiological Basis Of Migraine written by Turgay Dalkara and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-07 with Medical categories.
Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.
The Calcitonin Gene Related Peptide Family
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Author : Deborah L. Hay
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-03
The Calcitonin Gene Related Peptide Family written by Deborah L. Hay and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-03 with Medical categories.
In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.
Calcitonin Gene Related Peptide Promotes Peripheral And Central Trigeminal Sensitization
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Author : Lauren Cornelison
language : en
Publisher:
Release Date : 2015
Calcitonin Gene Related Peptide Promotes Peripheral And Central Trigeminal Sensitization written by Lauren Cornelison and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Calcitonin gene-related peptide categories.
Temporomandibular joint disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of my study was to investigate the role of calcitonin gene-related peptide (CGRP) on the initiation and maintenance of a nocifensive withdrawal response to mechanical stimulation following activation of primary trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats that were injected with CGRP alone or co-injected with inhibitors and determined changes in nocifensive behavior and inflammatory proteins. Intrathecal injection of CGRP increased nocifensive responses to mechanical stimulation up to 48 hours and this stimulatory effect was blocked by the antagonist peptide CGRP 8−37 and a protein kinase A inhibitor. Results provide evidence that elevated levels of CGRP in the spinal cord can promote bidirectional signaling within the trigeminal system, a novel finding that helps to explain how central sensitization can lower the activation threshold of primary nociceptors in TMD patients.
Update On Emerging Treatments For Migraine
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-09-05
Update On Emerging Treatments For Migraine written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-05 with Science categories.
Update on Emerging Treatments for Migraine, Volume 255, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Updated release includes the latest information on Update on Emerging Treatments for Migraine
Asthma And Copd
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Author : Peter J. Barnes
language : en
Publisher: Elsevier
Release Date : 2009-03-19
Asthma And Copd written by Peter J. Barnes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-19 with Medical categories.
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
White Matter Diseases
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Author : Massimo Filippi
language : en
Publisher: Springer Nature
Release Date : 2020-02-13
White Matter Diseases written by Massimo Filippi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-13 with Medical categories.
This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.
Chemotherapy Induced Neuropathic Pain
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Author : Robert B. Raffa
language : en
Publisher: CRC Press
Release Date : 2012-07-24
Chemotherapy Induced Neuropathic Pain written by Robert B. Raffa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-24 with Health & Fitness categories.
There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early