The Role Of Receptors In Biology And Medicine
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The Role Of Receptors In Biology And Medicine
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Author : Argenteuil Symposium Staff
language : en
Publisher:
Release Date : 1986-01-01
The Role Of Receptors In Biology And Medicine written by Argenteuil Symposium Staff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-01-01 with categories.
The Role Of Receptors In Biology And Medicine
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Author : Antonio M. Gotto
language : en
Publisher: Raven Press (ID)
Release Date : 1986
The Role Of Receptors In Biology And Medicine written by Antonio M. Gotto and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Cell receptors categories.
The Receptors
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2014-05-10
The Receptors written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-10 with Science categories.
The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.
G Protein Coupled Receptors
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Author : Jesus Giraldo
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011-08-16
G Protein Coupled Receptors written by Jesus Giraldo and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-16 with Science categories.
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.
Mechanisms Of Receptor Regulation
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Author : George Poste
language : en
Publisher:
Release Date : 2014-01-15
Mechanisms Of Receptor Regulation written by George Poste and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
The Imidazoline Receptor
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Author : Donald J. Reis
language : en
Publisher:
Release Date : 1995
The Imidazoline Receptor written by Donald J. Reis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Activating And Inhibitory Immunoglobulin Like Receptors
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Author : M. D. Cooper
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Activating And Inhibitory Immunoglobulin Like Receptors written by M. D. Cooper and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.
Sigma Receptors Their Role In Disease And As Therapeutic Targets
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Author : Sylvia B. Smith
language : en
Publisher: Springer
Release Date : 2018-06-13
Sigma Receptors Their Role In Disease And As Therapeutic Targets written by Sylvia B. Smith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-13 with Medical categories.
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
G Protein Coupled Receptors In Drug Discovery
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Author : Kenneth H. Lundstrom
language : en
Publisher: CRC Press
Release Date : 2005-07-11
G Protein Coupled Receptors In Drug Discovery written by Kenneth H. Lundstrom and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-11 with Science categories.
The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs and their involvement in various human diseases. The book presents current approaches in drug discovery that include target selection, establishment of screening and functional assays. It also covers recombinant GPCR expression for drug screening and structural biology, different methods for structural characterization of GPCRs, and the importance of bioinformatics. The book has been carefully edited to avoid overlapping information, some duplication has been intentionally permitted so that each chapter can function as an independent unit. Providing in-depth discussions on structure and dynamics of GPCRs, this book outlines the importance of the GPCRs to drug discovery in general and drug targets specifically. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
The Mobile Receptor Hypothesis
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Author : David A. Jans
language : en
Publisher: Springer
Release Date : 1997-05-15
The Mobile Receptor Hypothesis written by David A. Jans and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-15 with Medical categories.