The Sarcomere And Skeletal Muscle Disease

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The Sarcomere And Skeletal Muscle Disease

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Author : Nigel G. Laing
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-29

The Sarcomere And Skeletal Muscle Disease written by Nigel G. Laing and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-29 with Medical categories.

Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.

Skeletal Muscle Muscular Dystrophy

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Author : Donald Fischman
language : en
Publisher: Biota Publishing
Release Date : 2009-01-01

Skeletal Muscle Muscular Dystrophy written by Donald Fischman and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Science categories.

Histologically, muscle is conveniently divided into two groups, striated and nonstriated, based on whether the cells exhibit cross-striations in the light microscope (Figure 3). Smooth muscle is involuntary: its contraction is controlled by the autonomic nervous system. Striated muscle includes both cardiac (involuntary) and skeletal (voluntary). The former is innervated by visceral efferent fibers of the autonomic nervous system, whereas the latter is innervated by somatic efferent fibers, most of which have their cell bodies in the ventral, motor horn of the spinal cord. Smooth muscle is designed to have slow, relatively sustained contractions, while striated muscle contracts rapidly and usually phasically. Both cardiac and smooth muscle cells are mononucleated, whereas skeletal muscle cells (fibers) are multinucleated. [In aging hearts or hypertrophied hearts, cardiac muscle cells are often binucleated.] Multinucleation of skeletal muscle arises during development by the cytoplasmic fusion of muscle precursor cells, myoblasts. Adult skeletal muscle cells do not divide; that is also true of most cardiac myocytes. However, skeletal muscle exhibits a considerable amount of regeneration after injury. This is because adult skeletal muscle contains a stem cell, the satellite cell, which lies beneath the basement membrane surrounding the muscle fibers. [The multinucleation of cardiac muscle arises from karyokinesis without cytokinesis.] A diagrammatic series of enlargements of skeletal muscle are shown in Figure 4. A bundle of muscle fibers (fasciculus) is cut from the deltoid muscle. Each muscle cell is termed a myofiber or muscle fiber. Each muscle fiber contains contractile organelles termed myofibrils, which contain the contractile units of muscle termed sarcomeres. The sarcomeres are composed of myofilaments, which in turn are composed of contractile proteins. Muscle connective tissue layers are organized in concentric layers that are important in the entry and exit of vessels and nerves to and from the tissue. These are shown in Figure 5. The outermost layer is the epimysium or muscle sheath. Connective tissue septae (perimysium) run radially into the muscle tissue, dividing it into muscle fascicles. The deepest layer, surrounding each of the muscle fibers is the endomysium. The endomysium is in direct contact with a basal lamina that ensheathes each muscle fiber. It surrounds the plasma membrane of the muscle fiber termed the sarcolemma.

Pathology Of Skeletal Muscle

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Author : Stirling Carpenter
language : en
Publisher: New York : Churchill Livingstone
Release Date : 1984

Pathology Of Skeletal Muscle written by Stirling Carpenter and has been published by New York : Churchill Livingstone this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.

This book has been described as the bible of muscle disease, from both a scientific and a clinical point of view. It is a comprehensive work that explains and illustrates in detail all pathological reactions of skeletal muscles that occur in human disease. The microscopic changes are illustrated by histochemistry, immunocytochemistry, resin histology, and electron microscopy. The pathological findings are correlated with the clinical picture whenever possible. The interpretation of the findings is scientifically based. To facilitate this process, the fundamentals of normal histology and biology of the muscle cell are also covered.The book has been thoroughly revised and expanded for this Second Edition to provide up-to-date coverage of the relevant molecular biology and molecular genetics, as well as extensive references. It has been well organized and richly illustrated by the authors, who have been at the forefront of muscle pathology and neuromuscular research for 35 years. This practical reference work is intended for neuropathologists, neurologists, and general pathologists who look at muscle biopsies. It will also serve as an introduction to muscle disease for neurology and pathology residents.

Skeletal Muscle In Health And Disease

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Author : David A. Jones
language : en
Publisher: Manchester University Press
Release Date : 1990

Skeletal Muscle In Health And Disease written by David A. Jones and has been published by Manchester University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Muscles categories.

An understanding of muscle structure and function, and its control in health and failure in disease is a basis for a full understanding of human physiology. This book combines basic but up-to-date information about the structure, biochemistry and physiology of muscle with discussions on the use of muscle in everyday life, in sport and in disease.

The Sarcomere And Skeletal Muscle Disease

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Author : Nigel G. Laing
language : en
Publisher: Springer
Release Date : 2008-11-24

The Sarcomere And Skeletal Muscle Disease written by Nigel G. Laing and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-24 with Medical categories.

Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.

Skeletal Muscle Pathology

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Author : Frank L. Mastaglia
language : en
Publisher: W.B. Saunders Company
Release Date : 1992

Skeletal Muscle Pathology written by Frank L. Mastaglia and has been published by W.B. Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.

Aimed at the diagnostic pathologist and neurologist, this text is organized by disease, with introductory chapters on morphology, immunology, pathogenesis and biopsy technique. The second edition includes information on pathogenesis of muscle disease.

Skeletal Muscle

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Author : Henning Schmalbruch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Skeletal Muscle written by Henning Schmalbruch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This volume is intended to cover research in the field of muscle morphology since publication of the previous edition by Haggquist in 1956. The development of new techniques, coupled with an intensified interest in muscle, has resulted in a vast literature which no single person could review, especially within the limitations of one volume. When I accepted the flattering offer to write a new edition, I quickly abandoned any hope of a comprehensive review. Instead, I tried to consider, within my limits, those lines of research which I believe to be important for the understanding of mammalian and ultimately human muscles under normal, experimental, and pathological conditions. It would be naive to suggest that muscle can be adequately described in purely morphologi cal aspects; I would characterize the results of my effort as "muscle as seen with the eyes of a morphologist". It gives me pleasure to acknowledge the help of several colleagues who read and commented on drafts of individual chapters: Dr. Brenda Eisenberg, Chicago; Dr. Else Nygaard, Copenhagen; Dr. Stefano Schiaffino, Padova; Dr. Michael Sjostrom, Umea; Dr. Lars~Erik Thornell, Umea. None of these individ uals can be held responsible for any error or obscurity that persists. Indeed, without their assistance there would have been more. I also thank those col leagues who allowed me to include their published and unpublished material; their names, and also those of the publishers who kindly granted copyright permission, are given in the individual figure captions.

Pathology Of Skeletal Muscle Diseases

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Author : U. DeGirolami
language : en
Publisher:
Release Date : 1982

Pathology Of Skeletal Muscle Diseases written by U. DeGirolami and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Muscles categories.

Disorders Of Voluntary Muscle

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Author : George Karpati
language : en
Publisher: Cambridge University Press
Release Date : 2001-07-12

Disorders Of Voluntary Muscle written by George Karpati and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-12 with Medical categories.

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Diseases Of Skeletal Muscle

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Author : Robert Wortmann
language : en
Publisher:
Release Date : 2000

Diseases Of Skeletal Muscle written by Robert Wortmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.

To help today's clinicians meet the diagnostic and management challenge of patients presenting with weakness or fatigue, this outstanding guide brings together a respected editor and contributors, all experienced in the diagnosis and management of muscle disease. The book's complete review of skeletal muscle biology is followed by comprehensive descriptions and management options for a wide range of muscle diseases. The "Approach to the Patient" section provides a concise overview of diagnostic strategies. This is the only clinical resource of its kind--an outstanding hands-on resource for the clinician treating patients with skeletal muscle disease.