The Science And Engineering Of Granulation Processes


The Science And Engineering Of Granulation Processes
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The Science And Engineering Of Granulation Processes


The Science And Engineering Of Granulation Processes
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Author : Jim Litster
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

The Science And Engineering Of Granulation Processes written by Jim Litster and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.


This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the Particle Science and Technology Research Center in Dupont). As we played in the sand, we shared an excitement for developments in particle technology, especially particle characterization, that would lead operations such as granulation to be placed on a sound scientific and engineering footing. The immediate outcome from this interaction was the development of new industry short courses in granulation and related topics which we taught together both in Australia and North America. This book follows closely the structure and approaches developed in these courses, particularly the emphasis on particle design in granulation, where the impact of both formulation properties and process variables on product attributes needs to be understood and quantified. The book has been a long time in the making. We have been actively preparing the book for at least five years. Although the chapters have relatively good bibliographies, this book is not a review of the field. Rather it is an attempt by the authors to present a comprehensive engineering approach to granulator design, scale up and operation. It is exciting for us to see the explosion of research interest around the world in this area in the last five to seven years. Some of the most recent work will have to find its way into the second edition.



Granulation


Granulation
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Author : Agba D. Salman
language : en
Publisher: Elsevier
Release Date : 2006-11-24

Granulation written by Agba D. Salman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-24 with Technology & Engineering categories.


Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector. Four themes run through the book: 1. The Macro Scale processing for Granulation – including up to date descriptions of the methods used for granulation and how they come about and how to monitor – on-line these changes. 2. The Applications of granulation from an industrial perspective, with current descriptive roles and how they are undertaken with relevance to industry, and effective properties. 3. Mechanistic descriptions of granulation and the different rate processes occurring within the granulator. This includes methods of modelling the process using Population – Balance Equations, and Multi-level Computational Fluid Dynamics Models. 4. The Micro Scale: Granules and Smaller, looking at single granules and there interactions and modelling, while also considering the structure of granules and their constituent liquid bridges. * Covers a wide range of subjects and industrial applications * Provides an understanding of current issues for industrial and academic environments * Allows the reader an understanding of the science behind engineered granulation processes



Granulation And Granulation Processes


Granulation And Granulation Processes
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Author : Jiliang Xia
language : en
Publisher:
Release Date : 2006

Granulation And Granulation Processes written by Jiliang Xia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.




Handbook Of Pharmaceutical Granulation Technology


Handbook Of Pharmaceutical Granulation Technology
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Author : Dilip M. Parikh
language : en
Publisher: CRC Press
Release Date : 2021-05-11

Handbook Of Pharmaceutical Granulation Technology written by Dilip M. Parikh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-11 with Medical categories.


Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies



How To Scale Up A Wet Granulation End Point Scientifically


How To Scale Up A Wet Granulation End Point Scientifically
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Author : Michael Levin
language : en
Publisher: Academic Press
Release Date : 2015-10-07

How To Scale Up A Wet Granulation End Point Scientifically written by Michael Levin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-07 with Medical categories.


How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point. Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process. Thoroughly referenced and based on the latest research and literature Part of the Expertise in Pharmaceutical Process Technology Series edited by internationally respected expert, Michael Levin Illustrates the most common problems related to scale-up of a wet granulation end point and provides valuable insights on how to solve these problems in a practical way



Pharmaceutical Blending And Mixing


Pharmaceutical Blending And Mixing
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Author : P. J. Cullen
language : en
Publisher: John Wiley & Sons
Release Date : 2015-07-20

Pharmaceutical Blending And Mixing written by P. J. Cullen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-20 with Technology & Engineering categories.


Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.



Granularity In Materials Science


Granularity In Materials Science
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Author : George Kyzas
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-24

Granularity In Materials Science written by George Kyzas and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Science categories.


Granular materials are a special topic of recent research and are a milestone of science and technology. These materials are very simple: they are large conglomerations of discrete macroscopic particles. Granular materials have a broad area of development, which is growing rapidly day by day. Their impact on commercial applications and academia and education is huge. The basic points of this book are the important applications and properties of granular materials. For example, special mention is made of rheological points, shapes, and civil engineering aspects.



Granulation Technology For Bioproducts


Granulation Technology For Bioproducts
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Author : Kiran L. Kadam
language : en
Publisher: CRC-Press
Release Date : 1990-11-20

Granulation Technology For Bioproducts written by Kiran L. Kadam and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-20 with Science categories.


Granulation technology is important to the manufacturing of many bioproducts, such as detergent enzymes (biologically-derived products) and pharmaceuticals (bioactive products). This book describes the granulation of bioproducts through traditional approaches, such as fluidized bed granulation, spray drying, high-shear granulation and extrusion-spheronization, in addition to the application of newer approaches such as microencapsulation and liquid phase granulation. Freeze drying is also covered, which is the preferred mode for producing granular starter cultures used in the dairy industry. In addition to discussions regarding the full spectrum of suitable granulation processes, post-granulation steps such as drying (for wet processes) and coating are explained. The slant of the book is practical, which is borne out by chapters regarding the various industrial processes used to manufacture granular detergent enzymes and immobilized glucose isomerase and the selection of proper granulation processes for specific applications. Granulation Technology for Bioproducts is an important book for all bioproduct processing engineers.



Predictive Modeling Of Pharmaceutical Unit Operations


Predictive Modeling Of Pharmaceutical Unit Operations
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Author : Preetanshu Pandey
language : en
Publisher: Woodhead Publishing
Release Date : 2016-09-26

Predictive Modeling Of Pharmaceutical Unit Operations written by Preetanshu Pandey and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Medical categories.


The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points



Dynamic Flowsheet Simulation Of Solids Processes


Dynamic Flowsheet Simulation Of Solids Processes
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Author : Stefan Heinrich
language : en
Publisher: Springer Nature
Release Date : 2020-06-20

Dynamic Flowsheet Simulation Of Solids Processes written by Stefan Heinrich and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-20 with Science categories.


This book presents the latest advances in flowsheet simulation of solids processes, focusing on the dynamic behaviour of systems with interconnected solids processing units, but also covering stationary simulation. The book includes the modelling of solids processing units, for example for comminution, sifting and particle formulation and also for reaction systems. Furthermore, it examines new approaches for the description of solids and their property distributions and for the mathematical treatment of flowsheets with multivariate population balances.