The Spatiotemporal Dynamics Of Longevity Defining Cellular Processes And Its Modulation By Genetic Dietary And Pharmacological Anti Aging Interventions
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The Spatiotemporal Dynamics Of Longevity Defining Cellular Processes And Its Modulation By Genetic Dietary And Pharmacological Anti Aging Interventions
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Author : Vladimir I. Titorenko
language : en
Publisher: Frontiers E-books
Release Date :
The Spatiotemporal Dynamics Of Longevity Defining Cellular Processes And Its Modulation By Genetic Dietary And Pharmacological Anti Aging Interventions written by Vladimir I. Titorenko and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Aging of multicellular and unicellular eukaryotic organisms is a highly complex biological phenomenon that affects a plethora of processes within cells. This wide array of longevity-defining cellular processes - which are governed by an evolutionarily conserved signaling network - includes oxidative metabolism and protein synthesis in mitochondria, lipid and carbohydrate metabolism, NAD+ homeostasis, amino acid biosynthesis and degradation, ammonium and amino acid uptake, ribosome biogenesis and translation, proteasomal protein degradation, nuclear DNA replication, chromatin assembly and maintenance, actin organization, apoptosis, necrosis, autophagy, protein folding, stress response, signal transduction, cell cycle, and cell growth. The focus of this Frontiers Special Topic Issue is on an important conceptual advance in our understanding of how cells integrate and control these numerous processes and how genetic, dietary and pharmacological anti-aging interventions extend longevity by altering their functional states and spatiotemporal dynamics. The Issue will highlight the various strategies used by evolutionarily diverse organisms for coordinating these longevity-defining cellular processes in space and time, critically evaluate the molecular and cellular mechanisms underlying such coordination, and outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field.
Anti Aging Pharmacology
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Author : Vitaly Koltover
language : en
Publisher: Academic Press
Release Date : 2022-12-07
Anti Aging Pharmacology written by Vitaly Koltover and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Medical categories.
Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. Includes updated information about current developments in anti-aging pharmacology Offers practical advice on the applicability of certain healthspan-promoting medications Discusses potential challenges related to the translation of anti-aging drugs in clinical practice
The Retardation Of Aging And Disease By Dietary Restriction
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Author : Richard Weindruch
language : en
Publisher: Charles C Thomas Pub Limited
Release Date : 1988-01-01
The Retardation Of Aging And Disease By Dietary Restriction written by Richard Weindruch and has been published by Charles C Thomas Pub Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Health & Fitness categories.
Molecular Biology Of Aging
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Author : Leonard Guarente
language : en
Publisher: CSHL Press
Release Date : 2008
Molecular Biology Of Aging written by Leonard Guarente and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Aging categories.
This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
Anti Aging Drugs
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Author : Alexander M Vaiserman
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-01-18
Anti Aging Drugs written by Alexander M Vaiserman and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Medical categories.
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Cognitive Enhancement
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Author : Shira Knafo
language : en
Publisher: Academic Press
Release Date : 2014-12-20
Cognitive Enhancement written by Shira Knafo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-20 with Medical categories.
Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals. Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations Topics are discussed in terms of both human and animal studies
Advanced Healthcare Materials
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Author : Ashutosh Tiwari
language : en
Publisher: John Wiley & Sons
Release Date : 2014-05-09
Advanced Healthcare Materials written by Ashutosh Tiwari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Technology & Engineering categories.
Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Modulating Aging And Longevity
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Author : S.I. Rattan
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-09-30
Modulating Aging And Longevity written by S.I. Rattan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-30 with Science categories.
After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.
Cell Free Synthetic Biology
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Author : Jian Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-13
Cell Free Synthetic Biology written by Jian Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-13 with Science categories.
Critical Needs And Gaps In Understanding Prevention Amelioration And Resolution Of Lyme And Other Tick Borne Diseases
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-07-01
Critical Needs And Gaps In Understanding Prevention Amelioration And Resolution Of Lyme And Other Tick Borne Diseases written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-01 with Medical categories.
A single tick bite can have debilitating consequences. Lyme disease is the most common disease carried by ticks in the United States, and the number of those afflicted is growing steadily. If left untreated, the diseases carried by ticks-known as tick-borne diseases-can cause severe pain, fatigue, neurological problems, and other serious health problems. The Institute of Medicine held a workshop October 11-12, 2010, to examine the state of the science in Lyme disease and other tick-borne diseases.