The State Of Art In Immuno Oncology What To Do With Glioblastoma
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The State Of Art In Immuno Oncology What To Do With Glioblastoma
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Author : Xiaoxing Xiong
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-30
The State Of Art In Immuno Oncology What To Do With Glioblastoma written by Xiaoxing Xiong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-30 with Medical categories.
Glioblastoma State Of The Art And Future Perspectives
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Author : Ghazaleh Tabatabai
language : en
Publisher: MDPI
Release Date : 2020-12-10
Glioblastoma State Of The Art And Future Perspectives written by Ghazaleh Tabatabai and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-10 with Science categories.
Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.
Glioblastoma Multiforme
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Author : James Markert
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2005
Glioblastoma Multiforme written by James Markert and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Brain Neoplasms categories.
Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more.
Innovative Theranostic Approaches Towards Neuro Immunology In Gliomas
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Author : Lijie Zhai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-05
Innovative Theranostic Approaches Towards Neuro Immunology In Gliomas written by Lijie Zhai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-05 with Medical categories.
Immunotherapeutic Strategies For The Treatment Of Glioma
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Author : Christopher Jackson
language : en
Publisher: Academic Press
Release Date : 2021-09-10
Immunotherapeutic Strategies For The Treatment Of Glioma written by Christopher Jackson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Science categories.
Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward
Immunology And Immunotherapy Of Head And Neck Cancer
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Author : Panagiota Economopoulou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-21
Immunology And Immunotherapy Of Head And Neck Cancer written by Panagiota Economopoulou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-21 with Medical categories.
Brain Tumor Imaging
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Author : Elke Hattingen
language : en
Publisher: Springer
Release Date : 2015-09-02
Brain Tumor Imaging written by Elke Hattingen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Medical categories.
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Tumor Organoids
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Author : Shay Soker
language : en
Publisher: Humana Press
Release Date : 2017-10-20
Tumor Organoids written by Shay Soker and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-20 with Medical categories.
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Implications Of Ferroptosis Related Genes To The Genetics Of Cancer Development
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Author : Lian Xiang Luo
language : en
Publisher: Frontiers Media SA
Release Date :
Implications Of Ferroptosis Related Genes To The Genetics Of Cancer Development written by Lian Xiang Luo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Science categories.