The Statistical Evaluation Of Medical Tests For Classification And Prediction
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The Statistical Evaluation Of Medical Tests For Classification And Prediction
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Author : Margaret Sullivan Pepe
language : en
Publisher: OUP Oxford
Release Date : 2003-03-13
The Statistical Evaluation Of Medical Tests For Classification And Prediction written by Margaret Sullivan Pepe and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-13 with Medical categories.
This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine.
Statistical Methods In Diagnostic Medicine
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Author : Xiao-Hua Zhou
language : en
Publisher: John Wiley & Sons
Release Date : 2014-08-21
Statistical Methods In Diagnostic Medicine written by Xiao-Hua Zhou and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-21 with Medical categories.
Praise for the First Edition " . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.
The Statistical Evaluation Of Medical Tests For Classification And Prediction
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Author : Margaret Sullivan Pepe
language : en
Publisher:
Release Date : 2003
The Statistical Evaluation Of Medical Tests For Classification And Prediction written by Margaret Sullivan Pepe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Biochemical markers categories.
This book describes statistical concepts and techniques for evaluating medical diagnostic tests and biomarkers for detecting disease. More generally, the techniques pertain to the statistical classification problem for predicting a dichotomous outcome. Measures for quantifying test accuracy are described including sensitivity, specificity, predictive values, diagnostic likelihood ratios and the Receiver Operating Characteristic Curve that is commonly used for continuous and ordinal valued tests. Statistical procedures are presented for estimating and comparing them. Regression frameworks for assessing factors that influence test accuracy and for comparing tests while adjusting for such factors are presented. This book presents many worked examples of real data and should be of interest to practicing statisticians or quantitative researchers involved in the development of tests for classification or prediction in medicine.
Fundamentals Of Clinical Data Science
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Author : Pieter Kubben
language : en
Publisher: Springer
Release Date : 2018-12-21
Fundamentals Of Clinical Data Science written by Pieter Kubben and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-21 with Medical categories.
This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
Multivariate Statistical Machine Learning Methods For Genomic Prediction
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Author : Osval Antonio Montesinos López
language : en
Publisher: Springer Nature
Release Date : 2022-02-14
Multivariate Statistical Machine Learning Methods For Genomic Prediction written by Osval Antonio Montesinos López and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-14 with Technology & Engineering categories.
This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.
Topics In Biostatistics
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Author : Walter T. Ambrosius
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-06
Topics In Biostatistics written by Walter T. Ambrosius and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-06 with Medical categories.
This book presents a multidisciplinary survey of biostatics methods, each illustrated with hands-on examples. It introduces advanced methods in statistics, including how to choose and work with statistical packages. Specific topics of interest include microarray analysis, missing data techniques, power and sample size, statistical methods in genetics. The book is an essential resource for researchers at every level of their career.
Regression Modeling Strategies
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Author : Frank E. Harrell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Regression Modeling Strategies written by Frank E. Harrell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Mathematics categories.
Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".
An Introduction To Model Based Survey Sampling With Applications
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Author : Ray Chambers
language : en
Publisher: Oxford University Press
Release Date : 2012-01-12
An Introduction To Model Based Survey Sampling With Applications written by Ray Chambers and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-12 with Mathematics categories.
This text brings together important ideas on the model-based approach to sample survey, which has been developed over the last twenty years. Suitable for graduate students and professional statisticians, it moves from basic ideas fundamental to sampling to more rigorous mathematical modelling and data analysis and includes exercises and solutions.
Finite Mixture Models
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Author : Geoffrey McLachlan
language : en
Publisher: John Wiley & Sons
Release Date : 2004-03-22
Finite Mixture Models written by Geoffrey McLachlan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-22 with Mathematics categories.
An up-to-date, comprehensive account of major issues in finitemixture modeling This volume provides an up-to-date account of the theory andapplications of modeling via finite mixture distributions. With anemphasis on the applications of mixture models in both mainstreamanalysis and other areas such as unsupervised pattern recognition,speech recognition, and medical imaging, the book describes theformulations of the finite mixture approach, details itsmethodology, discusses aspects of its implementation, andillustrates its application in many common statisticalcontexts. Major issues discussed in this book include identifiabilityproblems, actual fitting of finite mixtures through use of the EMalgorithm, properties of the maximum likelihood estimators soobtained, assessment of the number of components to be used in themixture, and the applicability of asymptotic theory in providing abasis for the solutions to some of these problems. The author alsoconsiders how the EM algorithm can be scaled to handle the fittingof mixture models to very large databases, as in data miningapplications. This comprehensive, practical guide: * Provides more than 800 references-40% published since 1995 * Includes an appendix listing available mixture software * Links statistical literature with machine learning and patternrecognition literature * Contains more than 100 helpful graphs, charts, and tables Finite Mixture Models is an important resource for both applied andtheoretical statisticians as well as for researchers in the manyareas in which finite mixture models can be used to analyze data.
Proof And Concepts In Rapid Diagnostic Tests And Technologies
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Author : Shailendra K. Saxena
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-09-07
Proof And Concepts In Rapid Diagnostic Tests And Technologies written by Shailendra K. Saxena and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-07 with Medical categories.
This book gives a comprehensive overview of the recent advancements and developments of rapid diagnostic tests (RDTs) and technologies, which are quite novel approaches and might be used as laboratory bench manual for the rapid diagnosis of the various disease conditions. The book focuses on various aspects and properties of RDTs, point-of-care tests (POCTs), quality control, assurance, calibration, safety, nano-/microfluidic technologies, and fusion with DNA technologies. I hope that this work might increase the interest in this field of research and that the readers will find it useful for their investigations, management, and clinical usage.