The Synthesis Of Nucleoside And Nucleotide Analogues As Potential Antiviral Agents
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The Synthesis Of Nucleoside And Nucleotide Analogues As Potential Antiviral Agents
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Author : Shin-Ichiro Shimizu
language : en
Publisher:
Release Date : 1991
The Synthesis Of Nucleoside And Nucleotide Analogues As Potential Antiviral Agents written by Shin-Ichiro Shimizu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Synthesis Of Carbocyclic Nucleoside And Nucleotide Analogues As Potential Antiviral Agents
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Author : Diane Mary Coe
language : en
Publisher:
Release Date : 1991
Synthesis Of Carbocyclic Nucleoside And Nucleotide Analogues As Potential Antiviral Agents written by Diane Mary Coe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Synthesis Of Nucleoside Analogues With Potential Antiviral Activity Against Negative Strand Rna Virus Targets
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Author :
language : en
Publisher:
Release Date : 1989
Synthesis Of Nucleoside Analogues With Potential Antiviral Activity Against Negative Strand Rna Virus Targets written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
The work described here is an attempt to synthesis nucleoside analogues which are targetted against the replicase of negative-strand viruses. Two lines of investigation have been attempted: (i) the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and (ii) the synthesis of potential nucleotide pro-drugs. A series of compounds of type (i) have been synthesised and submitted for biological evaluation. Strategies for the synthesis of compounds of type (ii) have been developed but we have not had time to prepare sufficient suitable material for testing purposes. (js).
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents
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Author : Giovanna Luoni
language : en
Publisher:
Release Date : 2004
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents written by Giovanna Luoni and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Antiviral agents categories.
Synthesis Purification And Characterization Of Novel Nucleoside Analogues As Potential Antiviral Agents
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Author : Michael Korn
language : en
Publisher:
Release Date : 2005
Synthesis Purification And Characterization Of Novel Nucleoside Analogues As Potential Antiviral Agents written by Michael Korn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Antiviral agents categories.
The Synthesis Of Novel Nucleosides And Nucleotides As Potential Antiviral Agents
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Author : Jayne H. M. Gould
language : en
Publisher:
Release Date : 1996
The Synthesis Of Novel Nucleosides And Nucleotides As Potential Antiviral Agents written by Jayne H. M. Gould and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents
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Author : Antonella Carangio
language : en
Publisher:
Release Date : 2002
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents written by Antonella Carangio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Antiviral agents categories.
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents
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Author : Olivier Bidet
language : en
Publisher:
Release Date : 2003
The Design Synthesis And Biological Evaluation Of Novel Nucleoside Analogues As Potential Antiviral Agents written by Olivier Bidet and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Antiviral agents categories.
Nucleotide Analogues As Antiviral Agents
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Author : John C. Martin
language : en
Publisher:
Release Date : 1989
Nucleotide Analogues As Antiviral Agents written by John C. Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Language Arts & Disciplines categories.
Largely in response to the AIDS epidemic, the amount of research directed toward the discovery of antiviral agents has greatly expanded. This new volume focuses on the potential of nucleotides to exert potent in vivo antiviral effects. It presents the findings of an international group of scientists who are carrying out research at the forefront of the nucleotide drug design. Twelve chapters describe many new concepts and results, much of which has been previously unpublished. This book assembles a valuable collection of information, offering insight into this increasingly important research topic.
Design Synthesis And Biological Evaluation Of Acyclic Nucleotide Prodrugs As Potential Antiviral Agents
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Author : Davide Carta
language : en
Publisher:
Release Date : 2012
Design Synthesis And Biological Evaluation Of Acyclic Nucleotide Prodrugs As Potential Antiviral Agents written by Davide Carta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Acyclovir (ACV) is an acyclic guanine nucleoside analogue used in the treatment of herpes simplex virus (HSV) and varicella zoster virus (VZV) infections. The human herpes virus-encoded thymidine kinase (HHV-TK) phosphorylates ACV generating ACV monophosphate, which is then converted to the active form ACV triphosphate by cellular kinases. The ProTide approach, causing the direct release of the monophosphate form into the cell, allows bypass of the first phosphorylation step of nucleoside analogues. In previous studies acyclovir ProTides were found to be active in vitro against human immunodeficiency virus (HIV), demonstrating a successful release of ACV monophosphate into the cell. In this work, an extensive study of structure-activity relationship was carried out varying the masking groups of the ACV ProTide. Subsequently, several substituents were considered on specific position of the guanine base and side chain of ACV resulting in the synthesis of the aryl phosphoramidate derivatives of ganciclovir, penciclovir, 6-O-alkyl acyclovir, 8-bromoacyclovir, and 8- methylacyclovir. These derivatives were evaluated in vitro for their antiviral activity against HSV, VZV, human cytomegalovirus (HCMV), and HIV. Enzymatic and molecular modeling studies were carried out in order to investigate the bioactivaton of the phosphoramidate derivatives synthesised in this work and correlate these results with their biological activity. Finally, the ProTide approach was also applied to cidofovir resulting in the formation of the phosphonoamidate derivative of cyclic cidofovir. The in vitro antiviral activity of this compound against herpes viruses and poxviruses is reported, as well as investigation of the mechanism of activation, using enzymatic and molecular modeling studies.