The Telomere
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The Telomere Effect
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Author : Dr. Elizabeth Blackburn
language : en
Publisher: Hachette UK
Release Date : 2017-01-03
The Telomere Effect written by Dr. Elizabeth Blackburn and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with Health & Fitness categories.
The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.
The Telomere
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Author : David Kipling
language : en
Publisher: Oxford University Press, USA
Release Date : 1995
The Telomere written by David Kipling and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Science categories.
Telomeres--specialized structures at ends of linear chromosomes--serve a fascinating range of functions that molecular biologists and geneticists are only beginning to understand and exploit. For example, telomeres distinguish the natural end of a chromosome from a simple double-strand break, stabilize chromosomes by protecting them from fusion or activating cell cycle checkpoints, and provide mechanisms to compensate for the loss of terminal DNA sequence that occurs when linear DNA molecules are replicated. This book--the first to cover this exciting and rapidly expanding field--integrates the increasingly disparate strands of telomere research to provide an invaluable survey of the subject. Topics include the role of telomeres in nuclear organization; telomere DNA sequence and unusual structures formed by telomeric sequences in vitro; replication of telomeric sequences by telomerase and how this relates to various DNA sequence features; proteins that bind or interact with telomeres; the role of telomeres in programmed and spontaneous chromosome breakage; recent speculation on the relationship between human telomere loss, aging, and cancer; telomere position effects on replication and transcription; Drosophila telomere function; and the relationships between human telomere structure, genome analysis, and genetic disease. In a discipline as rapidly developing as telomere research, this book will serve as a user-friendly and much-needed resource for students and researchers in molecular biology and molecular genetics.
The Telomere Conspiracy
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Author : Bruce Mason
language : en
Publisher: iUniverse
Release Date : 2011-09-26
The Telomere Conspiracy written by Bruce Mason and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Fiction categories.
How will the world as you know it come to an end? Call him Lou, please. His real name is Luigi Gubriace, but he is better known as Lou Gubrious, a depressive independent investigator with a penchant for taking the most dismal view possible of the state of the world. Lou calls it being realistic. In the near future the environment continues to deteriorate. As the world population approaches eight billion, the icecaps are still melting, the rainforests are burning, the oceans are dying, and we are losing more and more species. Lou thinks there is no hope for humanity, the biosphere is doomed, and there is no one with a truly effective idea that could save the world. The world is mad and were all going to die, he says. Lou is called back into action when high level diplomats choose him to investigate a mysterious series of isolated epidemics. Meanwhile, Lou has no idea of the powerful international forces at play, conspiring to save the living planet in the worst possible way.
Telomere
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Author : Marcelo Larramendy
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-11-23
Telomere written by Marcelo Larramendy and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-23 with Medical categories.
This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.
The Telomere Effect
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Author : Elizabeth Blackburn
language : en
Publisher: Hachette UK
Release Date : 2017-01-26
The Telomere Effect written by Elizabeth Blackburn and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Self-Help categories.
Have you ever wondered why some sixty-year-olds look and feel like forty-year-olds, and why some forty-year-olds look and feel like sixty-year-olds? More importantly - can you choose which outcome will happen to you? Written by Nobel Prize winner Elizabeth Blackburn and health psychologist Elissa Epel, The Telomere Effect reveals the ground-breaking science at the heart of ageing - and what you can do to help reverse it. While many factors contribute to ageing and illness, Elizabeth and Elissa's award-winning research has revealed that the length of our telomeres - the part of our chromosomes which determine how fast our cells age and die - can have a direct effect on how quickly or slowly we age. In this pioneering book, discover for the first time the many simple changes you can make to your diet, sleep and mental wellbeing to look after your telomeres. From which foods to eat, types of exercise to practise, various mind tricks to prevent stress - and how to shield your children from developing shorter telomeres from conception through to adolescence - start protecting your telomeres and your youth today.
Telomeres And Telomerase
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Telomeres And Telomerase written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.
Telomere Miracle
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Author : Ed Park, MD
language : en
Publisher: Hay House, Inc
Release Date : 2018-01-23
Telomere Miracle written by Ed Park, MD and has been published by Hay House, Inc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-23 with Health & Fitness categories.
What if everything you think you know about getting older and staying healthy is wrong? Ed Park, M.D., offers the revolutionary idea that disease and aging in humans all arises from a single source: genetic errors caused by shortening of telomeres, or the sequences of DNA at the ends of our chromosomes. Telomeres naturally wear down over time, and thus when cells replicate (as they do all the time in our bodies), they’re creating progressively poorer-quality duplicates of themselves, like making a Xerox of a Xerox of a Xerox. Ultimately, the body deteriorates, resulting in a range of ailments, many of which we associate with aging—from diabetes to hypertension to macular degeneration to cancer. Happily, Ed tells us, it’s possible to slow or even reverse this process and effectively turn back the clock. In The Telomere Miracle, he explains cutting-edge science in a lively style, using illustrations and metaphors ranging from auto parts to superheroes. Then he shows readers how they can intervene in the aging process by boosting the activity of the enzyme telomerase naturally by understanding and optimizing six key areas of breathing, mindset, sleep, exercise, diet, and supplements.
The Evolving Telomeres
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Author : Arthur J. Lustig
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-19
The Evolving Telomeres written by Arthur J. Lustig and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-19 with Genetics categories.
What controls the different rates of evolution to give rise to conserved and divergent proteins and RNAs? How many trials until evolution can adapt to physiological changes? Every organism has arisen through multiple molecular changes, and the mechanisms that are employed (mutagenesis, recombination, transposition) have been an issue left to the elegant discipline of evolutionary biology. But behind the theory are realities that we have yet to ascertain: How does an evolving cell accommodate its requirements for both conserving its essential functions, while also providing a selective advantage? In this volume, we focus on the evolution of the eukaryotic telomere, the ribo-nuclear protein complex at the end of a linear chromosome. The telomere is an example of a single chromosomal element that must function to maintain genomic stability. The telomeres of all species must provide a means to avoid the attrition from semi-conservative DNA replication and a means of telomere elongation (the telomere replication problem). For example, telomerase is the most well-studied mechanism to circumvent telomere attrition by adding the short repeats that constitutes most telomeres. The telomere must also guard against the multiple activities that can act on an unprotected double strand break requiring a window (or checkpoint) to compensate for telomere sequence loss as well as protection against non-specific processes (the telomere protection problem). This volume describes a range of methodologies including mechanistic studies, phylogenetic comparisons and data-based theoretical approaches to study telomere evolution over a broad spectrum of organisms that includes plants, animals and fungi. In telomeres that are elongated by telomerases, different components have widely different rates of evolution. Telomerases evolved from roots in archaebacteria including splicing factors and LTR-transposition. At the conserved level, the telomere is a rebel among double strand breaks (DSBs) and has altered the function of the highly conserved proteins of the ATM pathway into an elegant means of protecting the chromosome end and maintaining telomere size homeostasis through a competition of positive and negative factors. This homeostasis, coupled with highly conserved capping proteins, is sufficient for protection. However, far more proteins are present at the telomere to provide additional species-specific functions. Do these proteins provide insight into how the cell allows for rapid change without self-destruction?
The Telomerase Revolution
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Author : Michael Fossel
language : en
Publisher: Atlantic Books Ltd
Release Date : 2015-10-06
The Telomerase Revolution written by Michael Fossel and has been published by Atlantic Books Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-06 with Medical categories.
Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.
Summary Analysis Review Of Elizabeth Blackburn S And Elissa Epel S The Telomere Effect By Instaread
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Author : Instaread
language : en
Publisher: Instaread
Release Date : 2017-01-30
Summary Analysis Review Of Elizabeth Blackburn S And Elissa Epel S The Telomere Effect By Instaread written by Instaread and has been published by Instaread this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-30 with Study Aids categories.
Summary, Analysis & Review of Elizabeth Blackburn’s and Elissa Epel’s The Telomere Effect by Instaread Preview: The Telomere Effect by Elizabeth Blackburn and Elissa Epel describes advances in the field of gerontology and presents practical information on how to apply scientifically based guidance to daily life. An indicator of health and longevity is the condition of a person’s telomeres, which are protective DNA that exists as cap-like structures at the end of each chromosome. Telomeres have the capacity to accelerate or decelerate the aging process because of their critical role in cellular health. It’s critical to understand how they function within the body and how they respond, for better or worse, to variables including diet, sleep hygiene, exercise, stress, emotions, and environmental toxin exposure. Although some people like to believe that aging is entirely predestined by genetics, science has proven otherwise. Numerous studies have shown that a shift in lifestyle can radically alter the length of people’s “healthspan,” or the period in which they enjoy robust health… PLEASE NOTE: This is a Summary, Analysis & Review of the book and NOT the original book. Inside this Summary, Analysis & Review of Elizabeth Blackburn’s and Elissa Epel’s The Telomere Effect by Instaread: · Overview of the Book · Important People · Key Takeaways · Analysis of Key Takeaways About the Author With Instaread, you can get the key takeaways and analysis of a book in 15 minutes. We read every chapter, identify the key takeaways and analyze them for your convenience. Visit our website at instaread.co.