The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases
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The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases
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Author : 楊傑燊
language : en
Publisher:
Release Date : 2014
The Use Of Genome Wide Dna Methylation Microarray To Study Both The Common And Rare Diseases written by 楊傑燊 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with DNA categories.
Use Of Genome Wide Dna Methyla
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Author : Kit-San Yeung
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
Use Of Genome Wide Dna Methyla written by Kit-San Yeung and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Medical categories.
This dissertation, "The Use of Genome-wide DNA Methylation Microarray to Study Both the Common and Rare Diseases" by Kit-san, Yeung, 楊傑燊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: DNA methylation plays many important roles in human physiology such as imprinting and X chromosome inactivation (XCI), and therefore disruption in DNA methylation can lead to disease development. The objective of this study is to study the role of DNA methylation in both the common and rare disease, using Systemic Lupus Erythematosus (SLE) and chromosome X translocation as the example respectively. The genome-wide DNA methylation analysis was studied by Illumina HumanMethylation450 BeadChip, which is the microarray that allows the detection of more than 480,000 CpG sites across 99% of reference sequence genes. Numerous studies have shown that hypomethylation occurred in specific genes of SLE patients, and genome-wide DNA methylation analysis has never been performed in Chinese before. Since DNA methylation can be ethnicity-specific, we aim to identify the Chinese-specific DNA methylation pattern in SLE patients. Microarray results showed that differential DNA methylation changes were loci-specific, where 36 CpG sites showed loss of DNA methylation while 8 of them showed gain of it, representing 24 genes and 7 genes respectively. In order to replicate the microarray findings, bisulfite pyrosequencing was performed in an additional cohort of 100 patients and 100 controls on four hypomethylated genes, which were selected based on their relevance with immunity. Bisulfite pyrosequencing confirmed the microarray result that hypomethylation occurred in SLE, and were associated with increased in the corresponding gene's mRNA expressions. Gene ontology analysis revealed that hypomethylated genes identified in the microarray study were overrepresented in type I interferon pathway, where type I interferon has long been implicated in SLE pathogenesis. Therefore this study also support the importance of type I interferon in SLE from the epigenetic point of view. X;autosome translocation is a rare condition and the autosome with chromosome X translocated on can be inactivated by XCI, but DNA methylation change is rarely used to investigate the spread of XCI. In this study, we aim to identify genes subjected to XCI in X;15 translocation using the DNA methylation microarray. Results of microarray showed that 586 CpG sites spanning the long arm of chromosome 15 had DNA methylation gain of more than 20%. Since genes subjected to XCI are known to have gain of DNA methylation in their corresponding CpG-island promoters, the analysis was then focused on CpG sites in these regions, and a total of 75 sites representing 24 genes were hypermethylated. Nearly all of these CpG sites are located in region proximal to the breakpoint, from 15q11.2 to 15q21.3 accounting for 35Mb, suggesting that XCI was spread to the proximal region of 15q. Gain of DNA methylation, especially in the CpG-island promoter, can result in functional inactivation of genes, and therefore could explain the worsen phenotype of the patient. In conclusion, we successfully demonstrated the use of genome-wide DNA methylation microarray in different diseases, allowing the identification of genes or pathways important in diseases and opened the door for further investigation of the effect of these differentially methylated genes on disease. DOI: 10.5353/th_b5334844 Subjects: DNA - Methylation Medical genetics
Murray Nadel S Textbook Of Respiratory Medicine E Book
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Author : V. Courtney Broaddus
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-05-28
Murray Nadel S Textbook Of Respiratory Medicine E Book written by V. Courtney Broaddus and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-28 with Medical categories.
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. - Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. - Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. - Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. - Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. - Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. - Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. - Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. - Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.
Genomic Proteomics And Biotechnology
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Author : RC Sobti
language : en
Publisher: CRC Press
Release Date : 2022-12-29
Genomic Proteomics And Biotechnology written by RC Sobti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-29 with Medical categories.
High-throughput molecular technologies ("omics") can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways thereby allowing the discovery of biomarkers. Notably, the omics technologies along with and computational methods, bioprospecting, and artificial intelligence will continue to lead to better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Research breakthroughs obtained through these technologies can be used to enhance productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continued improvement in food security worldwide. Such breakthroughs are an urgent necessity because over the past 50 years, there has been an unprecedented increase in the world’s population, which will reach ten billion by the year 2050. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Besides food, animal by-products have found many applications in the fields of pharmaceuticals, cosmetics, and household and industrial products. Hence, the need to ameliorate the productivity, reproductivity, growth performance, and disease resistance in animals has created a worldwide interest in gaining a deeper understanding of animal biology, biotechnology and genomics, and proteomics. The present volume thoroughly discusses the omics studies in domestic and non-domestic animals and their role in mitigation of various challenges ahead. The volume thus focuses on i. Omics (genomics, proteomics, transcriptomics, metabolonomics) technologies in identifying, characterizing biodiversity ii. Role of molecular techniques for improvement of domestic and non-domestic organisms iii. Animal and alternative model systems (using stem cells, tissue engineering, cell free systems, 3D platforms etc.) for studying life phenomena iv. Genetically modified organisms as factories for the products
The Role Of The Fetal Membranes In Pregnancy And Birth
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Author : Tamas Zakar
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-25
The Role Of The Fetal Membranes In Pregnancy And Birth written by Tamas Zakar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-25 with Science categories.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 2013
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Cancer categories.
The Oxford Handbook Of Molecular Psychology
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Author : Turhan Canli
language : en
Publisher:
Release Date : 2015
The Oxford Handbook Of Molecular Psychology written by Turhan Canli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
This entry in the Oxford Library of Psychology compiles cutting-edge research organized around the concept "molecular psychology," which applies principles of molecular biology to the study of behavior and its neural underpinnings. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.
Genomics An Issue Of Nursing Clinics
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Author : Stephen D. Krau
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-12-28
Genomics An Issue Of Nursing Clinics written by Stephen D. Krau and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-28 with Medical categories.
This issue of Nursing Clinics of North America is Guest Edited by Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University and will focus on genomics. Article topics will include Genetic and Genomic Testing, Integrating Genomics into Research, Genomic Assessments and Interventions in Psychiatric Nursing Practice, Genomics in Critical Care, Cardiomyopathy and Genetics, Genetics and Chronic Diseases, Genomics and Patients with Rare Chronic Diseases, Epigenetics and the implications for disease processes, Impact of Genetics on Oncology Nursing, and Pharmacogenetics.
Kendig And Chernick S Disorders Of The Respiratory Tract In Children
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Author : Edwin L. Kendig
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-01-01
Kendig And Chernick S Disorders Of The Respiratory Tract In Children written by Edwin L. Kendig and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-01 with Medical categories.
This definitive text on respiratory disease in children has been completely updated and revised for the 7th Edition. Several new chapters have been added, including information on the impact of environmental pollution on lung disease in children. Provides the most authoritative and comprehensive coverage available of basic science and clinical problems related to pediatric lung disease.
Environmental Epigenetics
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Author : L. Joseph Su
language : en
Publisher: Springer
Release Date : 2015-05-18
Environmental Epigenetics written by L. Joseph Su and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-18 with Medical categories.
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.