The Virus And The Host
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Virus Host Cell Genetic Material Transport
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Author : William E. Schiesser
language : en
Publisher: Springer Nature
Release Date : 2021-12-01
Virus Host Cell Genetic Material Transport written by William E. Schiesser and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.
The reproduction and spread of a virus during an epidemic proceeds when the virus attaches to a host cell and viral genetic material (VGM) (protein, DNA, RNA) enters the cell, then replicates, and perhaps mutates, in the cell. The movement of the VGM across the host cell outer membrane and within the host cell is a spatiotemporal dynamic process that is modeled in this book as a system of ordinary and partial differential equations (ODE/PDEs). The movement of the virus proteins through the cell membrane is modeled as a diffusion process expressed by the diffusion PDE (Fick’s second law). Within the cell, the time variation of the VGM is modeled as ODEs. The evolution of the dependent variables is computed by the numerical integration of the ODE/PDEs starting from zero initial conditions (ICs). The departure of the dependent variables from zero is in response to the virus protein concentration at the outer membrane surface (the point at which the virus binds to the host cell). The numerical integration of the ODE/PDEs is performed with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The ODE/PDE dependent variables are displayed graphically with basic R plotting utilities. The R routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the ODE/PDE model, such as changes in the parameters and the form of the model equations.
Viruses
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Author : Paula Tennant
language : en
Publisher: Academic Press
Release Date : 2018-03-14
Viruses written by Paula Tennant and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-14 with Science categories.
Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived 'interactomics' as defined by the molecules and the processes by which virus gene products interact with themselves and their host's cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses
Activation Of Viruses By Host Proteases
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Author : Eva Böttcher-Friebertshäuser
language : en
Publisher: Springer
Release Date : 2018-05-31
Activation Of Viruses By Host Proteases written by Eva Böttcher-Friebertshäuser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-31 with Medical categories.
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cells categories.
Human Herpesviruses
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Author : Ann Arvin
language : en
Publisher: Cambridge University Press
Release Date : 2007-08-16
Human Herpesviruses written by Ann Arvin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Landfill
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Author : Tim Dee
language : en
Publisher:
Release Date : 2018-09-10
Landfill written by Tim Dee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-10 with Gulls categories.
In Landfill, Tim Dee argues that rubbish tips sustain life and offer an alternative view of how we should treat any species who dares to live so closely among humans. About the book, Tim Dee says: 'I have been a lifelong birdwatcher but more recently I have found myself spending time watching people watching birds. Gulls in Britain are no longer seagulls and I've been fascinated in the last decade by the various ways that these birds have come ashore and come closer to us. In some ways they seem to have become more like us than any other bird. We might now evolve together.'
Virus Structure
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-10-02
Virus Structure written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-02 with Science categories.
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. - Covers viral assembly using heterologous expression systems and cell extracts - Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment - Includes information on structural studies on antibody/virus complexes
Plant Virus Host Interaction
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Author : R.K. Gaur
language : en
Publisher: Elsevier
Release Date : 2013-12-07
Plant Virus Host Interaction written by R.K. Gaur and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-07 with Science categories.
Plant Virus-Host Interaction contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, and synergism, with pivotal coverage of RNA silencing and the counter-defensive strategies used by viruses to overcome the silencing response in plants. With a clear focus on plant virus evolution, including quantitative and population genetics, Plant Virus-Host Interaction provides insights on the major factors favoring disease emergence, such as genetic change in pathogen and host populations and changes in host ecology and environment. The book also examines socioeconomic implications of widespread plant viral agents. Contributions from leading experts around the globe provide varied perspectives, while comprehensive coverage ensures a complete look at this exciting field. - Covers the emergence of new viral diseases - Provides molecular approaches for virus-host interaction - Highlights RNA silencing and counter-defensive strategies - Discusses socioeconomic implications of viral spread and mitigation techniques
Plant Virus Host Interaction
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Author : R.K. Gaur
language : en
Publisher: Academic Press
Release Date : 2021-01-12
Plant Virus Host Interaction written by R.K. Gaur and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-12 with Science categories.
Plant Virus-Host Interaction: Molecular Approaches and Viral Evolution, Second Edition, provides comprehensive coverage of molecular approaches for virus-host interaction. The book contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, synergism with pivotal coverage of RNA silencing, and the counter-defensive strategies used by viruses to overcome the silencing response in plants. This new edition introduces new, emerging proteins involved in host-virus interactions and provides in-depth coverage of plant virus genes' interactions with host, localization and expression. With contributions from leading experts, this is a comprehensive reference for plant virologists, molecular biologists and others interested in characterization of plant viruses and disease management.
Assessment Of Future Scientific Needs For Live Variola Virus
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1999-04-30
Assessment Of Future Scientific Needs For Live Variola Virus written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-30 with Medical categories.
In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.