Therapeutic Implications Of Circadian Rhythms
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Therapeutic Implications Of Circadian Rhythms
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Author : Guangrui Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-10-12
Therapeutic Implications Of Circadian Rhythms written by Guangrui Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-12 with Circadian rhythms categories.
Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms
Science Of Circadian Rhythms An Issue Of Sleep Medicine Clinics E Book
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Author : Phyllis C. Zee
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-01-07
Science Of Circadian Rhythms An Issue Of Sleep Medicine Clinics E Book written by Phyllis C. Zee and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-07 with Medical categories.
Dr. Phyllis Zee has put together an expert panel of authors on the topic of the Science of Circadian Rhythms. Articles include: Neurobiology of Circadian Rhythm Regulation, Effect of Light and Melatonin and other Melatonin Receptor Agonists on Human Circadian Physiology, Consequences of Circadian Disruption on Cardiometabolic Health, Consequences Circadian Disruption on Neurologic and Psychiatric Health, Aging and Circadian Rhythms, Circadian and Homeostatic Regulation of Sleep and Performance, Circadian disruption in Psychiatric Disorders, and more!
Chronotherapeutics
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Author : P. H. Redfern
language : en
Publisher: Pharmaceutical Press
Release Date : 2003
Chronotherapeutics written by P. H. Redfern and has been published by Pharmaceutical Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Biological rhythms categories.
In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.
Advances In The Psychobiology Of Sleep And Circadian Rhythms
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Author : Melinda L. Jackson
language : en
Publisher: Taylor & Francis
Release Date : 2023-12-19
Advances In The Psychobiology Of Sleep And Circadian Rhythms written by Melinda L. Jackson and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-19 with Psychology categories.
Advances in the Psychobiology of Sleep and Circadian Rhythms features international experts from the fields of psychobiology, sleep research and chronobiology to address and review cutting-edge scientific literature concerning recent advances in the psychobiology of sleep, sleep disorders, such as sleep apnoea and insomnia, and circadian rhythms, across the lifespan. In this illuminating volume, Melinda L. Jackson and Sean P.A. Drummond bring together leading international researchers to review cross-cutting issues in the field, including sleep and pain, sleep and dementia risk, and sleep issues in paediatric populations as well as the interaction between sleep and health conditions in different populations. The chapters offer coverage of the major explanatory models which underpin the empirical work as well as a discussion of the relevant theoretical and conceptual models on issues arising with specific psychiatric and medical disorders, including depression, dementia, posttraumatic stress disorder and pain. They also address new research in the area of chronobiology, and circadian impacts on health and diseases. The chapters also discuss important methodological and ethical issues arising in research and include sections addressing implications for public policy and practitioner interventions in the context of different social and cultural environments. This volume will be a crucial resource for professionals, practitioners and researchers engaged in the field as well as for postgraduate and upper-level undergraduate students undertaking research in areas related to psychobiology, neuropsychology, health psychology and other disciplines such as biology, physiology and psychopharmacology.
Circadian Rhythm Sleep Wake Disorders
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Author : R. Robert Auger
language : en
Publisher: Springer Nature
Release Date : 2020-05-26
Circadian Rhythm Sleep Wake Disorders written by R. Robert Auger and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-26 with Medical categories.
This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.
Circadian Rhythms And Their Impact On Aging
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Author : S. Michal Jazwinski
language : en
Publisher: Springer
Release Date : 2017-10-24
Circadian Rhythms And Their Impact On Aging written by S. Michal Jazwinski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-24 with Medical categories.
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
Circadian Rhythm Disorders An Issue Of Neurologic Clinics
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Author : Phyllis C. Zee
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-07-03
Circadian Rhythm Disorders An Issue Of Neurologic Clinics written by Phyllis C. Zee and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-03 with Medical categories.
This issue of Neurologic Clinics, guest edited by Dr. Phyllis C. Zee, with consulting editor Randolph W. Evans, will focus on Circadian Rhythm Disorders. Topics include, but are not limited to, Circadian biology, Genetic basis of circadian rhythms, Implication of circadian rhythm misalignment on sleep and health, Assessment of circadian rhythms, Circadian Rhythm sleep-wake phase disorders, Irregular sleep-wake rhythm sleep –wake disorder, Non-24 hour sleep-wake rhythm disorder, Shift Work Sleep Disorder, Challenging cases, and Future of circadian and sleep medicine.
Chronotherapeutics For Affective Disorders
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Author : Anna Wirz-Justice
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2009
Chronotherapeutics For Affective Disorders written by Anna Wirz-Justice and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
'Light therapy' is the only treatment in psychiatry that directly evolved out of basic neurobiology research. It is recognized as the treatment of choice for seasonal affective disorder and has been successfully used in nonseasonal depression and other psychiatric or neurologic illnesses, including bulimia nervosa and Alzheimer's disease. At the same time, 'wake therapy' is the fastest antidepressant known. Chronotherapeutic combinations of light and wake therapy achieve fast results and, by reducing residual symptoms, also minimise relapse. This manual introduces chronotherapeutics for depression, a new synthesis of non-pharmacologic interventions designed to accelerate remission in bipolar and unipolar patients alike. It examines the underlying clinical research, explains the involvement of the circadian timing system, and provides hands-on instructions for treating inpatients and outpatients. Written by three of the most prominent experts in the research and clinical applications of chronotherapy, this book enables clinicians to implement its principles and let their patients benefit from its practicality and effectiveness.In this manual psychiatrists, psychologists and health care administrators find comprehensive overviews of theory, research background, practical guidelines, and future prospects. It is also essential reading for practitioners of sleep medicine.In this manual psychiatrists, psychologists, primary care physicians, and health care administrators find comprehensive overviews of theory, research background, practical guidelines, and future prospects. It is also essential reading for practitioners of sleep medicine.CET encourages patients to present this book to their doctors to acquaint them with chronotherapeutics and help pave the way toward knowledgeable supervision of light therapy.
Melatonin
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Author : Venkatramanujan Srinivasan
language : en
Publisher: CRC Press
Release Date : 2014-10-15
Melatonin written by Venkatramanujan Srinivasan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-15 with Medical categories.
There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.
Biological Implications Of Circadian Disruption
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Author : Laura K. Fonken
language : en
Publisher: Cambridge University Press
Release Date : 2023-10-12
Biological Implications Of Circadian Disruption written by Laura K. Fonken and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Psychology categories.
Exposure to electric light at night is ubiquitous in modern society. This book describes how our 24-hour circadian clock regulates our physiology and behavior and why light at the “wrong” time of day can impact our health.