Therapeutic Implications Of Circadian Rhythms

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Therapeutic Implications Of Circadian Rhythms

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Author : Guangrui Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-10-12

Therapeutic Implications Of Circadian Rhythms written by Guangrui Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-12 with Circadian rhythms categories.

Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms

Human Circadian Physiology

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Author : Charles A. Czeisler
language : en
Publisher:
Release Date : 1978

Human Circadian Physiology written by Charles A. Czeisler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Human physiology categories.

The Genetics Of Circadian Rhythms

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Author : Stuart Brody
language : en
Publisher: Academic Press
Release Date : 2011-09-26

The Genetics Of Circadian Rhythms written by Stuart Brody and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Medical categories.

In this book an international group of authors describes recent research on circadian rhythms in bacteria, fungi, plants, animals, and humans.

Biological Implications Of Circadian Disruption

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Author : Laura K. Fonken
language : en
Publisher: Cambridge University Press
Release Date : 2023-10-12

Biological Implications Of Circadian Disruption written by Laura K. Fonken and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Psychology categories.

Life on earth has evolved under a consistent cycle of light and darkness caused by the earth's rotation around its axis. This has led to a 24-hour circadian system in most organisms, ranging all the way from fungi to humans. With the advent of electric light in the 19th century, cycles of light and darkness have drastically changed. Shift workers and others exposed to high levels of light at night are at increased risk of health problems, including metabolic syndrome, depression, sleep disorders, dementia, heart disease, and cancer. This book will describe how the circadian system regulates physiology and behavior and consider the important health repercussions of chronic disruption of the circadian system in our increasingly lit world. The research summarized here will interest students in psychology, biology, neuroscience, immunology, medicine, and ecology.

Circadian Rhythms And Cancer Hallmarks Toward Advances In Immune Based Therapeutics And Outcomes

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Author : Elizabeth Cash
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-13

Circadian Rhythms And Cancer Hallmarks Toward Advances In Immune Based Therapeutics And Outcomes written by Elizabeth Cash and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-13 with Medical categories.

Circadian rhythms are the daily fluctuations in physiological processes that govern cell cycles and timing of behaviors. Cancer hallmarks are the cellular properties that drive the perennial growth, survival and spread of cancerous cells. The disruption of circadian rhythms can contribute to the development of some cancers by affecting the expression of genes that regulate cell growth and division, as well as their interaction with the host microenvironment and anti-cancer treatment. Some cancer cells have been found to have altered circadian rhythms compared to normal cells, which may contribute to their uncontrolled growth. Patients exhibiting disrupted circadian rhythms tend to suffer accelerated tumor growth and metastasis, tumors that are more resistant to treatment, and poorer health-related quality of life and overall survival. Circadian rhythms also temporally regulate cellular immunity, which has important implications for the burgeoning field of immune-based therapeutics. Further research is needed to better understand the relationship between circadian rhythms and cancer hallmarks, and how this knowledge can be used to improve immunotherapy outcomes, cancer patients’ well-being and survival. This timely research topic is focused within a field that produced two Nobel prize awards in Physiology or Medicine, in 2017 for circadian rhythm research, and in 2018 for the discovery of cancer immunotherapy. The aim of this special issue is to highlight clinical, translational and epidemiological science - that includes objective assessments of both circadian disruption and cancer hallmarks - in order to help elucidate the impact of circadian rhythms on processes associated with cancer and its treatments, immunotherapy in particular.

Circadian Rhythm

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Author : Mohamed A. El-Esawi
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-07-04

Circadian Rhythm written by Mohamed A. El-Esawi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-04 with Medical categories.

Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.

Circadian Rhythms Sleep And Inflammation

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Author : Pawan K. Jha
language : en
Publisher: Springer Nature
Release Date : 2025-01-01

Circadian Rhythms Sleep And Inflammation written by Pawan K. Jha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-01 with Science categories.

The circadian clock is a complex cellular mechanism that controls numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of the clock system influences the immune response and brain functions. Immune activation is closely linked with inflammation, neurodegeneration, aging, and other peripheral and central nervous system-related abnormalities. There is increasing evidence that cellular inflammation affects sleep and circadian rhythms and vice-versa. This book offers a structured overview that focuses on the multi-angle interaction of circadian rhythms, sleep, and inflammatory response in normal or pathological conditions.

Biological Rhythms

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Author :
language : en
Publisher:
Release Date : 1991

Biological Rhythms written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Business & Economics categories.

Biological Rhythms And Behavior

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Author : J. Mendlewicz
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1983-06

Biological Rhythms And Behavior written by J. Mendlewicz and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983-06 with Medical categories.

Biological Rhythms

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Author : DIANE Publishing Company
language : en
Publisher: DIANE Publishing
Release Date : 1994-04

Biological Rhythms written by DIANE Publishing Company and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-04 with Science categories.

Discusses biological rhythms: what they are, how they are controlled by the brain, and the role they play in regulating physiological and cognitive functions. The major focus of the report is the examination of the effects of nonstandard work hours on biological rhythms and how these effects can interact with other factors to affect the health, performance, and safety of workers. Over 100, photos, drawings, charts, and tables.