Therapeutic Potential Of Cell Cycle Kinases In Breast Cancer
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Therapeutic Potential Of Cell Cycle Kinases In Breast Cancer
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Author : Manzoor Mir
language : en
Publisher: Springer Nature
Release Date : 2023-03-03
Therapeutic Potential Of Cell Cycle Kinases In Breast Cancer written by Manzoor Mir and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-03 with Medical categories.
This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
Cell Cycle Inhibitors In Cancer Therapy
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Author : Antonio Giordano
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-11-20
Cell Cycle Inhibitors In Cancer Therapy written by Antonio Giordano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-20 with Medical categories.
Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Checkpoint Responses In Cancer Therapy
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Author : Wei Dai
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-01
Checkpoint Responses In Cancer Therapy written by Wei Dai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-01 with Medical categories.
Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Breast Cancer Biology
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Author : Dil Afroze
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-08
Breast Cancer Biology written by Dil Afroze and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Medical categories.
This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Inhibitors Of Cyclin Dependent Kinases As Anti Tumor Agents
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Author : Paul J. Smith
language : en
Publisher: CRC Press
Release Date : 2006-10-25
Inhibitors Of Cyclin Dependent Kinases As Anti Tumor Agents written by Paul J. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-25 with Medical categories.
One of few books to cover all aspects of cyclin-dependent kinases (CDKs), this volume examines CDKs as molecular and functional entities, their role in various disease processes, and their potential for pharmacological modulation. The book first explains the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors. Then it examines the design, development, and chemistry of small molecule CDK inhibitors. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future prospects of CDK inhibitors as anticancer agents.
Breast Cancer Chemosensitivity
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Author : Dihua Yu
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-30
Breast Cancer Chemosensitivity written by Dihua Yu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-30 with Medical categories.
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.
Protein Kinase C In Cancer Signaling And Therapy
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Author : Marcelo G. Kazanietz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-10
Protein Kinase C In Cancer Signaling And Therapy written by Marcelo G. Kazanietz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-10 with Medical categories.
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Novel Targets In Breast Disease
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Author : Stan Lipkowitz
language : en
Publisher: IOS Press
Release Date : 2003
Novel Targets In Breast Disease written by Stan Lipkowitz and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
This work is devoted to therapies that take advantage of molecular targets relevant to breast cancer - so called novel molecular therapies. It presents a sampling of both old and new molecularly targeted therapies that are being developed.
Protein Kinase Ck2 Cellular Function In Normal And Disease States
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Author : Khalil Ahmed
language : en
Publisher: Springer
Release Date : 2015-03-03
Protein Kinase Ck2 Cellular Function In Normal And Disease States written by Khalil Ahmed and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-03 with Medical categories.
Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.
Cell Cycle Regulation
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Author : Philipp Kaldis
language : en
Publisher: Springer
Release Date : 2010-11-18
Cell Cycle Regulation written by Philipp Kaldis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-18 with Science categories.
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.