Therapeutic Relevance And Mechanisms Of Neuro Immune Communication In Brain Injury
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Therapeutic Relevance And Mechanisms Of Neuro Immune Communication In Brain Injury
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Author : Zhang Pengyue
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-25
Therapeutic Relevance And Mechanisms Of Neuro Immune Communication In Brain Injury written by Zhang Pengyue and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-25 with Science categories.
The brain is a critical organ with neuro-immune communication. The nervous system and immune system evolved to provide regulation of physiological homeostasis and protect against threats. Neuro-immune communication is correlated with physiological functions of various tissues and organs, and the internal environment balance. In brain trauma, the neural network is destroyed and the neuro-immune communication process is impaired. However, the research on this process is insufficient and limited. A thorough clarification of the cellular and molecular mechanisms of neuro-immune communication in brain injury is an essential necessary endeavor in the search for new therapeutic targets for brain injury. This Research Topic is devoted to the cellular and molecular mechanisms of neuro-immune communication in brain injury and on the meaningful exploration of how the nervous system regulates the immune system to promote neurofunctional recovery after brain injury.
Brain Neurotrauma
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Author : Firas H. Kobeissy
language : en
Publisher: CRC Press
Release Date : 2015-02-25
Brain Neurotrauma written by Firas H. Kobeissy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-25 with Medical categories.
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Clinical Relevance Of The Immune To Brain And Brain To Immune Communications
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Author : Julie Lasselin
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-29
Clinical Relevance Of The Immune To Brain And Brain To Immune Communications written by Julie Lasselin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-29 with categories.
Experimental and clinical evidence demonstrates an intense crosstalk among the nervous, endocrine and immune systems. The central nervous system (CNS) not only has the capacity to affect peripheral immune function, but is also able to sense and process signals from the peripheral immune system. The bi-directional interaction between the CNS and the peripheral immune system has gained great interest as it can help better understand disease pathophysiology as well as improving health and treatment outcomes in patients. On the one hand, inflammatory factors are known to affect CNS functions and to induce neuropsychiatric symptoms, making immune-to-brain communication highly relevant for psychiatric diseases and their treatments. On the other hand, analyzing pathways of brain-to-immune communication will help to understand the pathophysiology of chronic inflammatory disorders and will form the basis for optimizing treatment of these diseases.
Translational Research In Traumatic Brain Injury
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Author : Daniel Laskowitz
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Translational Research In Traumatic Brain Injury written by Daniel Laskowitz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Ferroptosis In Stroke Neurotrauma And Neurodegeneration Volume Ii
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Author : Anwen Shao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-31
Ferroptosis In Stroke Neurotrauma And Neurodegeneration Volume Ii written by Anwen Shao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Science categories.
This Research Topic is part of the Ferroptosis in Stroke, Neurotrauma and Neurodegeneration series: Ferroptosis in Stroke, Neurotrauma and Neurodegeneration Ferroptosis is a recently defined iron-dependent non-apoptotic form of cell death. Diverse stressors can destabilize metabolic processes in the cell, leading to excessive intracellular accumulation of reactive oxygen species that culminate in the collapse and rupture of the membrane structure of cellular organelles, such as mitochondria, endoplasmic reticulum, and lysosome. Ferroptosis is a form of cell death characterized by the accumulation of intracellular iron and lipid ROS. The primary morphologic manifestations of ferroptosis include cell volume shrinkage and increased mitochondrial membrane density. These are different from apoptotic types of cell death such as necroptosis (early destruction of membrane integrity, cell and organelle swelling, cytoplasmic granulation and chromatin fragmentation, and cellular lysis), and pyroptosis (necrosis-like cell-membrane pore formation and rupture, cellular swelling, pro-inflammatory intracellular content release, as well as apoptosis-like nuclear condensation and DNA fragmentation). Emerging evidence shows that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury (TBI), Alzheimer's disease and Parkinson's disease. Additionally, ferroptosis inhibition has been shown to protect neurons and ameliorate cognitive impairment in various disease animal models. To date, several ferroptosis inhibitors have been found. As Ferroptosis is characterized by the accumulation of intracellular iron and lipid ROS, these inhibitors are primarily categorized as either antioxidants or iron chelators. For example in hemorrhagic stroke, it was found that the neuronal death and iron deposition, induced by hemoglobin in organotypic hippocampal slice cultures and primary cortical neurons, can be attenuated by administration of ferrostatin-1, or other ferroptosis inhibitors. In this Research Topic researchers are welcome to submit original research and review articles. We are interested in all topics associated with ferroptosis and neurological diseases, from underlying mechanisms to clinical transformation including potential targeting and treatment and others. We also welcome original articles analyzing similarities and differences among ferroptosis and other kinds of cell death, such as apoptosis and pyroptosis, in neurological diseases and hope to find key insights for future drug-development.
Cytokines And Pain
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Author : Waldiceu A. Verri
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-28
Cytokines And Pain written by Waldiceu A. Verri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Medical categories.
Neuro Immune Interactions In Inflammation And Autoimmunity
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Author : Valentin A. Pavlov
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-24
Neuro Immune Interactions In Inflammation And Autoimmunity written by Valentin A. Pavlov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-24 with categories.
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.
Advances In Understanding Neurohiv Associated Changes In Neuroimmune Communication In The Combined Anti Retroviral Therapy Cart Era
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Author : Peter J. Gaskill
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-29
Advances In Understanding Neurohiv Associated Changes In Neuroimmune Communication In The Combined Anti Retroviral Therapy Cart Era written by Peter J. Gaskill and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-29 with Medical categories.
Itch
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Author : E. Carstens
language : en
Publisher: CRC Press
Release Date : 2014-02-25
Itch written by E. Carstens and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-25 with Medical categories.
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direc
Circadian Rhythms Sleep And Inflammation
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Author : Pawan K. Jha
language : en
Publisher: Springer Nature
Release Date : 2025-01-01
Circadian Rhythms Sleep And Inflammation written by Pawan K. Jha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-01 with Science categories.
The circadian clock is a complex cellular mechanism that controls numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of the clock system influences the immune response and brain functions. Immune activation is closely linked with inflammation, neurodegeneration, aging, and other peripheral and central nervous system-related abnormalities. There is increasing evidence that cellular inflammation affects sleep and circadian rhythms and vice-versa. This book offers a structured overview that focuses on the multi-angle interaction of circadian rhythms, sleep, and inflammatory response in normal or pathological conditions.