Therapeutic Vaccination Strategies
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Therapeutic Vaccination Strategies
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Author : P. Walden
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Therapeutic Vaccination Strategies written by P. Walden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
The induction of immune responses against tumor cells by vaccination is rapidly evolving as a therapeutic modality with new potentials for the treatment of cancer. It is based on the fact that our immune system can identify tumor cells and, once activated, is capable of developing specific immunity against the neoplastic cells. Numerous observations and intense research clearly document the major contribution of the immune system to the prevention of cancer. And there are many re ports of patients suffering from malignant melanoma or other tumors who mount a spontaneous immune response against their tumor cells that results in tumor regression. Based on the recent advances in our understanding of the compo nents of our immune system, their interactions and the regulation of immune responses, we are now able to design vaccination strategies that induce or enhance cell-mediated immunity against tumors. A ma jor advancement came with the identification and characterization of relevant tumor antigens, which are suitable target structures for anti-tu mor immune response. First clinical trials using such vaccine strategies have yielded encouraging results in patients. However, in spite of many reported cases of successful therapy of cancer by vaccination many patients still do not experience relief after such treatments. These initial clinical trials and the accompanying investigations have revealed a number of important results that indicate the direction of future re search and development in the field.
Therapeutic Vaccines As Novel Immunotherapy
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Author : Hironori Nakagami
language : en
Publisher: Springer Nature
Release Date : 2019-11-11
Therapeutic Vaccines As Novel Immunotherapy written by Hironori Nakagami and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Medical categories.
This book offers an excellent introduction to the use of novel therapeutic vaccines for common diseases based on their ability to induce antibody production. While the role of vaccines in the treatment of infectious diseases and cancer is well known, vaccines have also recently been developed for a variety of other conditions, including Alzheimer’s disease, hypertension, diabetes, and spondyloarthritis. These therapeutic advances are fully and clearly documented by acknowledged experts in the field, who explain the relevant biology and highlight the challenges involved in deploying this treatment approach effectively and safely. In addition, recent progress in the construction and delivery of DNA vaccines is documented, and the process of developing new peptide vaccines is explored in depth. While the book will be particularly valuable for researchers and scholars interested in immunotherapy, it will also appeal to clinicians seeking effective new medicines to treat patients suffering from chronic diseases.
Cancer Vaccines And Immunotherapy
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Author : Peter L. Stern
language : en
Publisher: Cambridge University Press
Release Date : 2000-08-17
Cancer Vaccines And Immunotherapy written by Peter L. Stern and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-17 with Medical categories.
Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.
Cancer Vaccination And Challenges
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Author : Bhupendra Prajapati
language : en
Publisher:
Release Date : 2024-11-22
Cancer Vaccination And Challenges written by Bhupendra Prajapati and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-22 with categories.
Novel Approaches And Strategies For Biologics Vaccines And Cancer Therapies
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Author : Manmohan Singh
language : en
Publisher: Academic Press
Release Date : 2014-12-30
Novel Approaches And Strategies For Biologics Vaccines And Cancer Therapies written by Manmohan Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-30 with Medical categories.
Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies
Vaccine Analysis Strategies Principles And Control
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Author : Brian K. Nunnally
language : en
Publisher: Springer
Release Date : 2014-11-27
Vaccine Analysis Strategies Principles And Control written by Brian K. Nunnally and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Medical categories.
This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities. Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.
Innovation In Vaccinology
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Author : Selene Baschieri
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-20
Innovation In Vaccinology written by Selene Baschieri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-20 with Medical categories.
Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.
Handbook Of Cancer Vaccines
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Author : Michael A. Morse
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-01-28
Handbook Of Cancer Vaccines written by Michael A. Morse and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-28 with Medical categories.
An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Cancer Vaccines As Immunotherapy Of Cancer
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Author : Luigi Buonaguro
language : en
Publisher: Academic Press
Release Date : 2022-03-04
Cancer Vaccines As Immunotherapy Of Cancer written by Luigi Buonaguro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-04 with Science categories.
Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide
Novel Technologies For Vaccine Development
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Author : Igor S Lukashevich
language : en
Publisher: Springer
Release Date : 2014-11-13
Novel Technologies For Vaccine Development written by Igor S Lukashevich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-13 with Medical categories.
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.