Thyroid Hormone Disruption And Neurodevelopment
DOWNLOAD
Download Thyroid Hormone Disruption And Neurodevelopment PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Thyroid Hormone Disruption And Neurodevelopment book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Thyroid Hormone Disruption And Neurodevelopment
DOWNLOAD
Author : Noriyuki Koibuchi
language : en
Publisher: Springer
Release Date : 2016-11-11
Thyroid Hormone Disruption And Neurodevelopment written by Noriyuki Koibuchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Medical categories.
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.
Toxic Cocktail
DOWNLOAD
Author : Barbara Demeneix
language : en
Publisher: Oxford University Press
Release Date : 2017
Toxic Cocktail written by Barbara Demeneix and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Children born to women exposed to thyroid-disrupting chemicals have lower IQs and more neurodevelopmental disorders in autism and ADHD, among others. Numerous chemicals that contaminate our bodies and interfere with our thyroids are in fact lowering our IQ and increasing disorders for future generations. A "self-help" guide to reducing exposure to chemicals is included.
Losing Our Minds
DOWNLOAD
Author : Barbara Demeneix
language : en
Publisher:
Release Date : 2014
Losing Our Minds written by Barbara Demeneix and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Mental health categories.
Global acceleration in neurodevelopmental disorders cannot be accounted for by genetic causes. Environmental chemicals interfering with thyroid hormone signalling are implicated. The author gives an historical overview of cases documenting environmental pollution causing IQ losses across populations, explains the physiology of thyroid hormone action, the importance of iodine and selenium for thyroid hormone signalling & brain development, why thyroid hormone is such a sensitive target of environmental pollution, and the role of gene x environment interactions in neurodevelopmental disorders.
Paediatric Thyroidology
DOWNLOAD
Author : G. Szinnai
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-09-15
Paediatric Thyroidology written by G. Szinnai and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-15 with Medical categories.
This book presents a comprehensive overview of pediatric thyroid diseases and thus provides a useful tool for clinical problem solving. Opinion leaders in the field present reviews on all relevant diseases of the hypothalamic-pituitary-thyroid axis. Sixteen chapters cover topics ranging from fetal thyroidology, congenital hypothyroidism, central hypothyroidism, inherited defects of thyroid hormone action, cell transport and metabolism to iodine deficiency, autoimmune thyroid disease and thyroid tumors. Written by clinicians, the chapters provide in-depth information and current guidelines for clinical problems encountered in pediatric thyroidology. As a unique feature, a case seminar collection for each chapter presents typical patient histories providing key learning points and key references for clinical problem solving in family medicine, pediatric endocrinology and medical genetics. Providing a succinct update on clinical pediatric thyroidology, this book is an essential tool for pediatric and adult endocrinologists, as well as for general practitioners, pediatricians and medical geneticists.
Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders
DOWNLOAD
Author : Michael Aschner
language : en
Publisher: Academic Press
Release Date : 2015-06-18
Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders written by Michael Aschner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-18 with Technology & Engineering categories.
Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. - Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders - Written by an international selection of the world's foremost experts in the field of neurotoxicology - Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action - An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience
Clinical Gynecology
DOWNLOAD
Author : Eric J. Bieber
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-23
Clinical Gynecology written by Eric J. Bieber and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-23 with Medical categories.
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
70 Years Of Levothyroxine
DOWNLOAD
Author : George J. Kahaly
language : en
Publisher: Springer
Release Date : 2022-01-31
70 Years Of Levothyroxine written by George J. Kahaly and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Medical categories.
This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.
Behavioral Toxicology
DOWNLOAD
Author : Bernard Weiss
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Behavioral Toxicology written by Bernard Weiss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Behavioral toxicology is a young discipline in the United States; so young, in fact, that this is one of its first books. Behavioral questions are bound to play a major role in future scientific work and governmental decisions involving the health effects of environmental contaminants and other chemicals. This role springs from two key problems that face scientists and public agencies required to set acceptable exposure standards or to determine criteria for the toxicity of therapeutic chemicals: How do you evaluate effects that may show up only as subtle functional disturbances? And how do you de tect toxic effects early enough so that they may still be reversible, before they produce major damage? The contributions in this book come from a collection of scientists whose interests span a wide variety of problem areas. The focus is largely on me thodological issues because they represent the most immediate concern of the discipline. We expect that this collection of papers will represent a useful source book for behavioral toxicology for some time. For the past few years, the University of Rochester's Department of Radiation Biology and Biophysics has sponsored a series of international conferences on chemical toxicity, partly as a response to concern over the con sequences to health of the rich chemical soup in which we live. This book is based upon presentations made to the fifth of the series. Held in June, 1972, it was the first formal meeting devoted to behavioral toxicology in this country.
Neurodevelopment And Intelligence Impacts Of Nutrition Environmental Toxins And Stress Volumes 1 And 2
DOWNLOAD
Author : Charles A. Lewis, MD MPH
language : en
Publisher: Psy Press
Release Date : 2022-03-01
Neurodevelopment And Intelligence Impacts Of Nutrition Environmental Toxins And Stress Volumes 1 And 2 written by Charles A. Lewis, MD MPH and has been published by Psy Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-01 with Medical categories.
This special edition of Neurodevelopment and Intelligence contains both Volumes One and Two. The set provides an understanding neurodevelopmental risks during fetal and early life, and of the things that can go awry that limit or hinder healthy brain development, leading to a loss of intellectual abilities or causing disabilities such as autism spectrum disorder. It should be of interest to anyone interested in brain health, preventive medicine, pediatrics, public health policy, present and prospective parents, and those planning on pregnancy and parturition. Herein, Dr. Lewis explains: How people got smarter for more than a century and and why the alternative title of the book is Swimming in a Poisoned Pond —The Looming Demise of Cognitive and Mental Health in America How any healthy child can be a genius with advanced planning All the nasty things in your home that cause brain damage The disgusting things in your water that harm the brain The prenatal vitamins that prevent autism How ADHD is a lifestyle disease The eight pillars of health and their effects on the brain What men can do to sire smarter children The environmental toxins that cause violent crime and suicide How to make your home safe for your child’s brain The role of gut bacteria on the brain How to make pregnancy safer for the fetal brain Foods that improve brain function Maternal life style factors that affect IQ The seven pillars of health and their effects on the brain What men can do to sire smarter children How to make your home safe for your child’s brain The role of gut bacteria on the brain The disruptive effects of sleep deprivation and sleep disordered breathing on brain development, and sleep hygiene for children The effects of stress on the brain and its functioning The harmful effects of poverty on the brain How noise and noise pollution harm brain development. How good public policy can give us a brighter future Foods that improve brain function and make us happy and engaged The effects of Exercise and Environmental Enrichment Kiss your genetic legacy goodbye! Why you will likely never be a grandparent if you don’t already have children How stress makes us stupid Why people are getting dumber even though we have better medical care and more access to education. Are we already too dumb to save ourselves from our mistakes? How psychopathic corporations, stupidity, and structural racism raid America’s wealth The book is a serious scientific exploration of neurodevelopment on which policy and personal behavior changes can be based to improve health, happiness, and intellectual curiosity. Section I section lays out an description of the Intelligence Quotient (IQ) and why it can used as a proxy for neurodevelopment. It explains IQ tests and other developmental scales scoring, and some of their limitations. The high metabolic cost of a large brain and the survival advantage provided by epigenetic adaptation to downsize the brain to the current environmental conditions is described, explaining why a less costly and less intelligent brain are adaptive to leaner times. An estimate is made for the average human IQ in full health and nutrition, (about two standard deviations above the current average, or an IQ of 130). A primer on inflammation is given. Section 2: discusses the impact of anemia and iron on brain development. Topics include: Hookworm, malaria, and infections. Most of this section discusses iron deficiency, iron supplementation in pregnancy and infancy, and the role other minerals and vitamins required for blood formation Section 3: Covers the role of iodine and thyroid hormone on neurodevelopment. The following chapters discuss thyroid hormone disruptors including fluoride and bromide, organohalogens, thyroid disrupting organic pollutants, organophosphates and other biocides, and foods and food additives that impact thyroid function Section 4 covers neurotoxic metals in the environment. The neurotoxic metals that most commonly impact brain health are discussed, including arsenic, lead, mercury, manganese. The impacts of cadmium and aluminum on fetal and infant health are reviewed. Toxic metal exposure during development most commonly occurs from water contamination, and Chapter 18 covers water filtration for removal of these toxins. Section 5 discusses the role of toxic metals, dietary factors, and the role of the intestinal microbiome on the causation and exacerbation of autism spectrum disorder. Evidence on the role of special diets for ASD is reviewed.The timing of the development of ASD is discussed; as it is essential to understanding which exposures are relevant and amenable to treatment. Section 6 discussed the generation of air pollution from combustion of fuels and the adverse impacts of it on brain health. Effects of Particulate matter (PM) on health, Alzheimer’s and Parkinson’s disease are reviewed, along with its effects on the premature birth of infants, neurodevelopment, IQ, and autism. Mitigation of risk is discussed. Section 7 outlines maternal factors that impact neurodevelopment and intelligence. The causes and effects of preterm birth and small for gestational age are explored, with a particular focus on environmental influences. Section 8 covers the effect of general health on neurodevelopment, including the impact of diet on the intestinal microbiome, exercise, sleep deprivation, sleep-disordered breathing, and explains the roll of lifestyle in ADHD. Section 9 discusses the effects of psychosocial stress on neurodevelopment and intellectual performance, and discusses the epigenetic effects of stress on brain development and behavior. The role of having a supportive social environment, a stimulating environment, and education on brain development, IQ an health are discussed. The effects of prenatal stress on the brain are reviewed. Other topics include the effect of stress and telomere length, the effects of poverty or domestic violence on IQ score, and the effects of stress on the hypothalamic-pituitary-adrenal axis and on the gut. The effects of noise on hearing, academic performance, and sleep are reviewed. The need to confront endemic stress as a societal norm is discussed.
Endocrine Disruption And Human Health
DOWNLOAD
Author : Philippa D. Darbre
language : en
Publisher: Academic Press
Release Date : 2021-09-19
Endocrine Disruption And Human Health written by Philippa D. Darbre and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-19 with Medical categories.
**Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease** Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations - Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology