Toward Anti Adhesion Therapy For Microbial Diseases
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Toward Anti Adhesion Therapy For Microbial Diseases
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Author : Itzahak Kahane
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Toward Anti Adhesion Therapy For Microbial Diseases written by Itzahak Kahane and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The emergence of pathogens resistant to conventional antimicrobial agents has forced us to intensify the efforts in search for new approaches to prevent infectious diseases. Such a direction was indicated in studies over the last two decades showing that adhesion of pathogens, primarily via glycoconjugate or protein receptors of the host tissue, is crucial for the infectious process. Moreover, it was found that infection can be prevented by blocking adhesion of the pathogen to mucosal surfaces of the host. The various aspects of interference with the process of microbial adhesion as a way of preventing diseases were the subject of the Bat-Sheva Seminar, "Towards Anti-Adhesion Therapy of Microbial Infectious Diseases," held in Zichron Yaakov, Israel, February 25 to March I, 1996. A major aim of the Bat-Sheva de Rothschild Foundation for the Advancement of Science in Israel, which sponsors a series of seminars, ours among them, is to provide the necessary tools and settings for international forums and exposure of young scientists and promising students to the state of the art of the field. This goal has been achieved during the week's discussions, and its major aspects are presented in this compendium. The seminar's participants, as well as the readers of this book, thank the founder and Foundation for their support. This book includes the major themes of this rapidly growing area. However, by no means do we intend to cover every bit and piece in it. The book's first section deals with the lectin-sugar interactions and their inhibitors.
Anti Adhesion Therapy Of Bacterial Diseases
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Author : Itzhak Ofek
language : en
Publisher:
Release Date : 2003
Anti Adhesion Therapy Of Bacterial Diseases written by Itzhak Ofek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Bacterial Adhesion To Host Tissues
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Author : Michael Wilson
language : en
Publisher: Cambridge University Press
Release Date : 2010-01-28
Bacterial Adhesion To Host Tissues written by Michael Wilson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-28 with Science categories.
This book is about the adhesion of bacteria to their human hosts. Although adhesion is essential for maintaining members of the normal microflora in/on their host, it is also the crucial first stage in any infectious disease. It is important, therefore, to fully understand the mechanisms underlying bacterial adhesion so that we may be able to develop methods of maintaining our normal (protective) microflora, and of preventing pathogenic bacteria from initiating an infectious process. These topics are increasingly important because of the growing prevalence of antibiotic-resistant bacteria and, consequently, the need to develop alternative approaches for the prevention and treatment of infectious diseases. This book describes the bacterial structures responsible for adhesion and the molecular mechanisms underlying the adhesion process. It also deals with the consequences of adhesion for both the adherent bacterium and the host cell/tissue to which it has adhered.
Bacterial Adhesion To Cells And Tissues
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Author : Itzhak Ofek
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Bacterial Adhesion To Cells And Tissues written by Itzhak Ofek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Attachment to host cells or tissues is often the first step in the establishment of bacterial infections. A complex array of recognition, attachment, and virulence factors is involved in this process, which recent research has greatly illuminated. This comprehensive and authoritative volume discusses the specific cell and tissue-specific affinities of pathogenic microorganisms, including bioinorganic surfaces such as teeth, and is an essential reference for researchers and students of host-pathogen interactions.
Development Of A Bacterial Adhesin Into A Next Generation Antimicrobial Agent
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Author : Fitua Minuar Aziz Al-Saedi
language : en
Publisher:
Release Date : 2018
Development Of A Bacterial Adhesin Into A Next Generation Antimicrobial Agent written by Fitua Minuar Aziz Al-Saedi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Anti-infective agents categories.
For most pathogenic bacteria, the adherence to host cells is a crucial step for infection. Therefore, targeting bacterial attachment could be a potential way for treating bacterial infections. This thesis focuses on the interactions between the adhesin Multivalent Adhesion Molecule (MAM7) from the commensal Escherichia coli strain HS with host receptors, aiming to understand the molecular basis of these interactions. Targeting the interactions between MAM7 and host cells was one of this study's aims towards developing anti-bacterial agents. In this study, HSMAM7 based adhesion inhibitors- beads coupled to HSMAM7 and an engineered bacterium expressing HSMAM7- were designed and their role as anti-adhesion agents against pathogenic bacteria was investigated. This study demonstrates that HSMAM7 based inhibitors have the ability to displace pathogenic bacteria from the host cells. Dissecting the binding of HSMAM7 to host receptors was the second part of this study. The findings revealed that HSMAM7 binds to sulfatide, several components of the extracellular matrix (ECM) and mucin. Further investigation of the interaction between HSMAM and host receptors revealed that HSMAM7 binds to mucin and the host lipid sulfatides via specific recognition of a shared 3-O-sulfo-galactosyl moiety in a sulfation dependent manner. Sulfatase-producing Bacteroides thetaiotaomicron affect the binding of HSMAM7 to mucin. HSMAM7 binding to mucin was inhibited in the presence of B. thetaiotaomicron and that means the commensal E. coli would be free and able to attach to the host epithelial cells, a finding of potential relevance for inflammatory bowel diseases (IBDs).
The Use Of Drugs In Food Animals
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1999-01-12
The Use Of Drugs In Food Animals written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-12 with Medical categories.
The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.
Desk Encyclopedia Of Microbiology
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Author : Moselio Schaechter
language : en
Publisher: Elsevier
Release Date : 2003-12-11
Desk Encyclopedia Of Microbiology written by Moselio Schaechter and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-11 with Science categories.
The Desk Encyclopedia of Microbiology aims to provide an affordable and ready access to a large variety of microbiological topics within one set of covers. This handy desk-top reference brings together an outstanding collection of work by the top scientists in the field. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field. * Provides a broad, easily accessible perspective on a wide range of microbiological topics * A synthesis of the broadest topics from the comprehensive and multi-volumed Encyclopedia of Microbiology, Second Edition * Helpful resource in preparing for lectures, writing reports, or drafting grant applications
Molecular Medical Microbiology
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Author : Yi-Wei Tang
language : en
Publisher: Academic Press
Release Date : 2014-09-14
Molecular Medical Microbiology written by Yi-Wei Tang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-14 with Science categories.
The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource. This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Comprising more than 100 chapters, organized into 17 major sections, the scope of this impressive work is wide-ranging. Written by experts in the field, chapters include cutting-edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology. Topics covered include bacterial structure, cell function, and genetics; mechanisms of pathogenesis and prevention; antibacterial agents; and infections ranging from gastrointestinal to urinary tract, centrtal nervous system, respiratory tract, and more. The first comprehensive and accessible reference on molecular medical microbiology Full color presentation througout In-depth discussion of individual pathogenic bacteria in a system-oriented approach Includes a clinical overview for each major bacterial group Presents the latest information on vaccine development, molecular technology, and diagnostic technology More than 100 chapters covering all major groups of bacteria Written by an international panel of authors who are experts in their respective disciplines
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1997
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medicine categories.
Emerging Infectious Diseases
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Author :
language : en
Publisher:
Release Date : 1998
Emerging Infectious Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Communicable diseases categories.