Toxicological And Pathophysiological Influence Of Lead And Protective Physiological Power Of Glutathione Through The Concentration Of Malondialdehyde In The Brain Of Rats
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Toxicological And Pathophysiological Influence Of Lead And Protective Physiological Power Of Glutathione Through The Concentration Of Malondialdehyde In The Brain Of Rats
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Author : Jasmina Jovanoviu0107 Mirkoviu0107
language : en
Publisher:
Release Date : 2017
Toxicological And Pathophysiological Influence Of Lead And Protective Physiological Power Of Glutathione Through The Concentration Of Malondialdehyde In The Brain Of Rats written by Jasmina Jovanoviu0107 Mirkoviu0107 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Lead contamination sources are products of combustion in metallurgy and chemical industry, traffic, industrial wastewater and landfills. Professionally, workers in smelters and foundries, paint industry, ceramic industry, batteries and accumulators factories and factories of weapons and ammunition are most exposed to lead. Every year, the industry produces about 2.5 million tons of lead worldwide. To examine the effect of chronic intoxication with heavy metals, lead (Pb) and the protective role of glutathione supplementation (GSH) through the value of the secondary lipid peroxidation product, malondialdehyde (MDA) in brain homogenate of Wistar albino rats. Monitoring of lipid peroxidation intensity was performed by measuring the value of malondialdehyde in brain tissue homogenates, spectrophotometrically. Increased MDA values, such as the biochemical marker of oxidative damage to cell membranes, indicate an enhanced lipid peroxidation process present in brain tissue homogenates due to chronic Pb intoxication. Reduction of MDA concentration in cases where experimental animals received supplements glutathione. Lead has a pronounced affinity for thiol groups which form a stable mercaptides and thus inactivates systems in natural conditions. Added GSH supplements reduce its negative effects and thus it is a desirable supplement and antioxidant in the detoxification of reactive oxygen species in rats that were subjected to lead poisoning.
Glutathione System And Oxidative Stress In Health And Disease
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-08-26
Glutathione System And Oxidative Stress In Health And Disease written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Lead Toxicity
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Author : Sarah E. Royce
language : en
Publisher:
Release Date : 2000
Lead Toxicity written by Sarah E. Royce and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Lead categories.
How Tobacco Smoke Causes Disease
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Author :
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Systems Biology Of Free Radicals And Antioxidants
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Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Impact Of Heavy Metals On The Environment
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Author : Jean-Pierre Vernet
language : en
Publisher: Elsevier Publishing Company
Release Date : 1992
Impact Of Heavy Metals On The Environment written by Jean-Pierre Vernet and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Nature categories.
Highlighted in this compilation of papers is the role and importance of heavy metals in the environment. It provides up-to-date information in a field of active research and progress, where the focus is on effects and interactions between the environment and organisms, as well as contaminant dynamics. Several papers address the impact of heavy metals on our health. The influence of metals on plants is described in an exhaustive study on lichens, which have been widely used as biomonitors for environmental contamination by heavy metals. Metals are also accumulated by animals, as seen in a chapter which focusses on sediment/benthic organism interactions and biomonitoring in fish. Soil interactions are discussed, as well as regional studies of freshwater sediments and the marine environment. The final part of the book addresses a crucial problem: the management of stabilized municipal waste sludges. As a result, the most important and significant recent trends are included, emphasizing interactions with and impacts of heavy metals on humans, animals, plants and soils.
Plant Derived Bioactives
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Author : Mallappa Kumara Swamy
language : en
Publisher: Springer Nature
Release Date : 2020-05-11
Plant Derived Bioactives written by Mallappa Kumara Swamy and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-11 with Science categories.
Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.
Dietary Reference Intakes For Vitamin C Vitamin E Selenium And Carotenoids
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2000-08-27
Dietary Reference Intakes For Vitamin C Vitamin E Selenium And Carotenoids written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-27 with Medical categories.
This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.
Heavy Metals And Health
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Author : Lance Castillo
language : en
Publisher: Nova Science Publishers
Release Date : 2016
Heavy Metals And Health written by Lance Castillo and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Heavy metals categories.
Heavy metals are persistent in the environment and their elevated emission during longer periods of time can cause contamination of the environment. They are emitted in all environmental media, but can also be easily transported between them due to the atmospheric deposition, water runoff, etc., and thus accumulate in the environment or penetrate the food chains. The main routes of human exposure to heavy metals are through ingestion, inhalation or via dermal contact. Hence, there is a need for better understanding of absorption, distribution and deposition of heavy metals in the human body. This information is of a crucial importance for the evaluation of heavy metal potential health implications. In this book, Chapter One provides an overview of the heavy metal health hazards, presented as a consequence of heavy metal pollution, their availability and cycling between different media in the environment. Chapter Two comprehensively discusses the roles and harmful effects of heavy metals on human health, as well as the sources and techniques of removing heavy metals from the environment. Chapter Three explores the mechanisms of mercury cardiovascular toxicity, with a particular emphasis on its effects toward endothelial cells. Chapter Four focuses on the effects of exposure to soil contaminated by metals. Chapter Five examines antimicrobial functionalized textiles. Chapter Six discusses thallium poisoning. Chapter Seven provides a review of heavy metal pollution, human exposure and public health implications in Nigeria.
Abiotic Stresses In Plants
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Author : Luigi Sanità di Toppi
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-11-30
Abiotic Stresses In Plants written by Luigi Sanità di Toppi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-30 with Nature categories.
This book provides a valuable insight into how the area of plant adaptation to abiotic stresses has progressed through the application of the new technologies. The book consists of eight chapters written by outstanding scientists across the world, who carry out research at the cutting edge of their disciplines. The topics, addressed in up-to-date specific chapters, include effects and responses of plants to stresses caused by such factors as: 1) high temperature, 2) low temperature (chilling and freezing), 3) salt, 4) drought, 5) flooding, 6) heavy metals, 7) elevated carbon dioxide, 8) ozone.