Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-01
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-01 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-05
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-05 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Telomeres
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Author : Aristidis Tsatsakis
language : en
Publisher: CRC Press
Release Date : 2025-02-05
Telomeres written by Aristidis Tsatsakis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-05 with Social Science categories.
This book provides a comprehensive overview of aging and its mechanisms through the prism of telomere length and its link to lifestyle parameters and environmental pollutants, diseases where telomere length attrition is prominent, and therapeutic approaches to slow down or prevent the process of telomere length reduction. It also provides an extensive comparison of the methodology for telomere length determination and characterization. The book will help researchers in any discipline to obtain an in-depth and broad knowledge of the most recent advances in telomere research written by specialists in the field. It is also addressed to the readers interested in gaining an insight into the processes of aging and those factors that affect “graceful” aging, enabling them to extract even useful tips in improving their everyday habits.
Pharmacological And Toxicological Screening Methods Ii
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Author : Dr. Trilochan Satapathy
language : en
Publisher: JEC PUBLICATION
Release Date :
Pharmacological And Toxicological Screening Methods Ii written by Dr. Trilochan Satapathy and has been published by JEC PUBLICATION this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
A complete handbook on toxicology covers basic principles, regulatory criteria, and sophisticated methods for understanding and assuring the safety of varied chemicals in the following pages. Introduction to toxicology, "Toxicology Fundamentals and Regulatory Guidelines," covers broad overviews, mechanistic toxicology, regulatory frameworks, and descriptive toxicology. Focus is on OECD, ICH, EPA, and Schedule Y regulatory criteria, as well as the history and importance of Good Laboratory Practise (GLP) in drug development. As the book explores "Types of Toxicity Studies and Test Item Characterization," it examines acute, sub-acute, chronic, and particular acute investigations, including oral, cutaneous, and inhalational toxicity studies. Test item characterisation procedures are carefully explained, emphasising their importance in regulatory compliance and toxicity evaluation. This leads to "Advanced Toxicology Studies," which covers reproductive toxicology, genotoxicity, and in vivo carcinogenicity. These investigations provide a thorough view of possible dangers and evaluate drug safety. The book then discusses "IND Enabling Studies and Safety Pharmacology," which covers the necessary research for IND applications. Exploring regulatory settings, corporate views, and safety pharmacology in drug development provides a complete knowledge of experimental substance safety. The third part, "Toxicokinetic and Alternatives to Animal Testing," emphasises toxicokinetic assessment and discusses new methods. Following the evolution of safety assessment practises, these options are investigated for ethical and regulatory consequences. Students, researchers, and professionals traversing toxicology's difficult landscape may find this book invaluable. Its extensive coverage, from basic concepts to sophisticated approaches, makes it an important tool for protecting humans and ecosystems in the dynamic pharmaceuticals and beyond industries.
Immunotoxicogenomics
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Author : Md. Naimat Ali
language : en
Publisher: Elsevier
Release Date : 2024-10-16
Immunotoxicogenomics written by Md. Naimat Ali and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-16 with Medical categories.
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives
Gut Microbiome And Environmental Toxicants
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Author : Gaurav Gupta
language : en
Publisher: CRC Press
Release Date : 2025-04-14
Gut Microbiome And Environmental Toxicants written by Gaurav Gupta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-14 with Business & Economics categories.
This book comprehensively reviews the intricate relationship between environmental toxicants and the gut microbiome. It explores the role of dietary choices and lifestyle in shaping and modulating the gut microbiome’s response to environmental toxicants. It examines the intricate relationship between these toxic substances and the composition, function, and overall health implications of the gut microbiome. The chapters provide in-depth insights into the impacts of various toxicants, such as phthalates, pesticides, organic pollutants, bisphenols, and heavy metals, on the delicate microbial balance within our digestive systems. Specific chapters address the impact of lead, mercury, cadmium, and arsenic on the composition and function of the gut microbiome. The book concludes by addressing future prospects and challenges in understanding and mitigating the impacts of environmental toxicants on the gut microbiome and highlighting the importance of these efforts. Key Features: Provides a comprehensive examination of the intricate relationship between environmental toxicants and the gut microbiome Reviews the possible mechanisms underlying bidirectional interactions between environmental pollutants and GI Examines the role of dietary choices and lifestyle factors in modulating the gut microbiome's response to environmental toxicants Covers the impact of toxic substances, phthalates, pesticides, and heavy metals on the gut microbiome Explores the practical implications of toxicant exposure on human health This book is intended for researchers and scientists working in the fields of environmental toxicology, microbiology, pharmacology, and related disciplines.
Mixture Toxicity
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Author : Cornelis A. M. van Gestel
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Mixture Toxicity written by Cornelis A. M. van Gestel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Computational Toxicology For Drug Safety And A Sustainable Environment
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Author : Tahmeena Khan, Saman Raza
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-12-18
Computational Toxicology For Drug Safety And A Sustainable Environment written by Tahmeena Khan, Saman Raza and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-18 with Science categories.
Computational Toxicology for Drug Safety and a Sustainable Environment is a primer on computational techniques in environmental toxicology for scholars. The book presents 9 in-depth chapters authored by expert academicians and scientists aimed to give readers an understanding of how computational models, software and algorithms are being used to predict toxicological profiles of chemical compounds. The book also aims to help academics view toxicological assessment from the lens of sustainability by providing an overview of the recent developments in environmentally-friendly practices. The chapters review the strengths and weaknesses of the existing methodologies, and cover new developments in computational tools to explain how researchers aim to get accurate results. Each chapter features a simple introduction and list of references to benefit a broad range of academic readers. List of topics: 1. Applications of computational toxicology in pharmaceuticals, environmental and industrial practices 2. Verification, validation and sensitivity studies of computational models used in toxicology assessment 3. Computational toxicological approaches for drug profiling and development of online clinical repositories 4. How to neutralize chemicals that kill environment and humans: an application of computational toxicology 5. Adverse environmental impact of pharmaceutical waste and its computational assessment 6. Computational aspects of organochlorine compounds: DFT study and molecular docking calculations 7. In-silico studies of anisole and glyoxylic acid derivatives 8. Computational toxicology studies of chemical compounds released from firecrackers 9. Computational nanotoxicology and its applications Readership Graduate and postgraduate students, academics and researchers in pharmacology, computational biology, toxicology and environmental science programs.
Cheminformatics Qsar And Machine Learning Applications For Novel Drug Development
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Author : Kunal Roy
language : en
Publisher: Elsevier
Release Date : 2023-05-23
Cheminformatics Qsar And Machine Learning Applications For Novel Drug Development written by Kunal Roy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-23 with Medical categories.
Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development aims at showcasing different structure-based, ligand-based, and machine learning tools currently used in drug design. It also highlights special topics of computational drug design together with the available tools and databases. The integrated presentation of chemometrics, cheminformatics, and machine learning methods under is one of the strengths of the book.The first part of the content is devoted to establishing the foundations of the area. Here recent trends in computational modeling of drugs are presented. Other topics present in this part include QSAR in medicinal chemistry, structure-based methods, chemoinformatics and chemometric approaches, and machine learning methods in drug design. The second part focuses on methods and case studies including molecular descriptors, molecular similarity, structure-based based screening, homology modeling in protein structure predictions, molecular docking, stability of drug receptor interactions, deep learning and support vector machine in drug design. The third part of the book is dedicated to special topics, including dedicated chapters on topics ranging from de design of green pharmaceuticals to computational toxicology. The final part is dedicated to present the available tools and databases, including QSAR databases, free tools and databases in ligand and structure-based drug design, and machine learning resources for drug design. The final chapters discuss different web servers used for identification of various drug candidates. - Presents chemometrics, cheminformatics and machine learning methods under a single reference - Showcases the different structure-based, ligand-based and machine learning tools currently used in drug design - Highlights special topics of computational drug design and available tools and databases
Essentials Of Pharmatoxicology In Drug Research Volume 1
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Author : Rakesh Kumar Tekade
language : en
Publisher: Elsevier
Release Date : 2023-03-23
Essentials Of Pharmatoxicology In Drug Research Volume 1 written by Rakesh Kumar Tekade and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-23 with Medical categories.
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research. - Examines toxicological risk assessment in drug research - Discusses toxicity mechanisms - Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology - Offers clinical interventions and managed care as a result of toxic injury and acute poisoning