Trafficking Of Bacterial Toxins
DOWNLOAD
Download Trafficking Of Bacterial Toxins PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Trafficking Of Bacterial Toxins book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Trafficking Of Bacterial Toxins
DOWNLOAD
Author : Catharine B. Saelinger
language : en
Publisher: CRC Press
Release Date : 1989-12-21
Trafficking Of Bacterial Toxins written by Catharine B. Saelinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-12-21 with Science categories.
This work represents a compilation of studies on the entry into and subsequent processing of several bacterial and plant toxins in mammalian cells. Emphasis is placed on the close parallel of mammalian cell processing of toxic proteins and physiologically essential ligands. This easy-to-read book includes chapters which review the structures of the toxins. It compares and contrasts the trafficking of pseudomonas and diphtheria toxins. It also discusses anthrax toxin and the clostridial neurotoxins.
Uptake And Trafficking Of Protein Toxins
DOWNLOAD
Author : Holger Barth
language : en
Publisher: Springer
Release Date : 2017-12-01
Uptake And Trafficking Of Protein Toxins written by Holger Barth and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Medical categories.
This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.
The Comprehensive Sourcebook Of Bacterial Protein Toxins
DOWNLOAD
Author : Joseph E. Alouf
language : en
Publisher: Elsevier
Release Date : 2015-06-05
The Comprehensive Sourcebook Of Bacterial Protein Toxins written by Joseph E. Alouf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-05 with Science categories.
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.
The Comprehensive Sourcebook Of Bacterial Protein Toxins
DOWNLOAD
Author : Joseph E. Alouf
language : en
Publisher: Academic Press
Release Date : 2015-05-29
The Comprehensive Sourcebook Of Bacterial Protein Toxins written by Joseph E. Alouf and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-29 with Science categories.
The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.
Bacterial Toxins
DOWNLOAD
Author : Otto Holst
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Bacterial Toxins written by Otto Holst and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.
The interest of investigators across a broad spectrum of scientific dis- plines has been steadily stimulated by the field of bacterial toxin research, an area that makes use of a large variety of biological, chemical, physicochemical, and medically oriented approaches. Researchers studying bacterial toxins need to be acquainted with all these disciplines in order to work effectively in the field. To date, there has been no published collection offering detailed descr- tions of the techniques and methods needed by researchers operating across the field’sdiverse areas. The present volume Bacterial Toxins: Methods and Pro- cols, is intended to fill this gap. Bacterial Toxins: Methods and Protocols consists of two sections: one on protein toxins (15 chapters) and one on endotoxins (5 chapters). Each s- tion is introduced by an overview article (Chapters 1 and 16). The protocols collected represent state-of-the-art techniques that each have high impact on future bacterial toxin research. All methods are described by authors who have regularly been using the protocol in their own laboratories. Included in each chapter is a brief introduction to the method being described.
Bacterial Toxins
DOWNLOAD
Author : John Stephen
language : en
Publisher:
Release Date : 1986
Bacterial Toxins written by John Stephen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Bacterial Protein Toxins
DOWNLOAD
Author : Alistair J. Lax
language : en
Publisher: Cambridge University Press
Release Date : 2011-04-28
Bacterial Protein Toxins written by Alistair J. Lax and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.
Bacterial Exotoxins How Bacteria Fight The Immune System
DOWNLOAD
Author : Inka Sastalla
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-07
Bacterial Exotoxins How Bacteria Fight The Immune System written by Inka Sastalla and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-07 with Immunologic diseases. Allergy categories.
Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Toxin
DOWNLOAD
Author : Alistair J. Lax
language : en
Publisher: OUP Oxford
Release Date : 2005-10-27
Toxin written by Alistair J. Lax and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-27 with Science categories.
What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants. In Toxin, Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defences of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and how apparently 'new' diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modern microbiology grew, Toxin is the first widely accessible account of this exciting and important topic.
Bacterial Toxins
DOWNLOAD
Author : Thomas Proft
language : en
Publisher: Caister Academic Press Limited
Release Date : 2013
Bacterial Toxins written by Thomas Proft and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Science categories.
Toxins are virulence determinants that play an important role in microbial pathogenicity and/or evasion of the host immune response. This makes them ideal targets for the development of novel antimicrobial strategies. The potential applications of toxin research extend beyond simply combating microbial pathogens and include use as novel anti-cancer drugs and other front-line medicines and as tools in neurobiology. In the field of cellular biology, toxins have become invaluable as tools for the manipulation and investigation of fundamental cellular and physiological processes. Research in this area is thriving and at a very exciting stage. This timely volume serves as an update on the most important recent advances in the genetics, cellular biology and practical applications of the most important bacterial toxins. Written by internationally respected scientists from eight different countries, topics reviewed include: the molecular basis and risk factors for verotoxin pathogenesis; molecular mechanisms of Helicobacter pylori CagA translocation and function; structure and mechanisms of action of pore-forming toxins; bacterial enterotoxins as immunomodulators and vaccine adjuvants; mobile genetic elements as carriers for bacterial virulence genes; the novel family of staphylococcal superantigen-like toxins (SSLs); new insights into the use of botulinum neurotoxins as therapeutics; microbial toxins as tools in cell biology; the role of the large clostridial cytotoxins in C. difficile disease. Essential reading for everyone with an interest in bacterial toxins and recommended book for researchers interested in microbial genomics and microbial pathogenesis.