Trained Immunity Based Vaccines
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Trained Immunity Based Vaccines
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Author : Jose Luis Subiza
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-25
Trained Immunity Based Vaccines written by Jose Luis Subiza and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Trained Immunity Based Vaccines
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Author : José Luis Luis Subiza
language : en
Publisher:
Release Date : 2022
Trained Immunity Based Vaccines written by José Luis Luis Subiza and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Electronic books categories.
Viral outbreaks have become significant threats to global human public health. New emerging viruses, pathogen mutations, and even the progressive loss of efficacy in some existing vaccines are behind this problem, which is amplified by the rapid virus spread given the ease of current mobility. Taking into account that these outbreaks arise in the absence of conventional effective vaccines, alternative approaches based on trained (innate) immunity are being considered. This immunity is dependent on a functional reprogramming of innate immune cells, leading to an enhanced nonspecific response towards different pathogens, including viruses. Trained immunity-based vaccines (TIbVs), defined as vaccine formulations containing trained immunity inducers, could be used during viral outbreaks to confer non-specific protection but also to enhance adaptive specific immune responses. In this chapter, we aim to illustrate how TIbVs could tackle the above-mentioned situations derived from viral outbreaks, reviewing the potential of available TIbVs in such urgent situations with a special mention to COVID-19.
Vaccines And Approaches That Target Trained Immunity In Covid 19 Immunological Mechanisms Of Action And Delivery
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Author : Yongjun Sui
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-30
Vaccines And Approaches That Target Trained Immunity In Covid 19 Immunological Mechanisms Of Action And Delivery written by Yongjun Sui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Medical categories.
Heterologous Immunity Implications And Applications In Vaccines And Immunotherapies
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Author : Babita Agrawal
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Heterologous Immunity Implications And Applications In Vaccines And Immunotherapies written by Babita Agrawal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.
Innate Immunity In Health And Disease
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Author : Shailendra K. Saxena
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-08-25
Innate Immunity In Health And Disease written by Shailendra K. Saxena and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.
Vaccination Of Special Populations Protecting The Vulnerable
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Author : Paolo Palma
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-30
Vaccination Of Special Populations Protecting The Vulnerable written by Paolo Palma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-30 with Medical categories.
Vaccines prevent 3 million of deaths every year and are a crucial to combat antimicrobial resistance. An optimal implementation of existing vaccines could help to avert up to 1.5 million deaths as well as substantial disabilities. Indeed, vulnerable populations (VPs), including pregnant women, newborns, preterm infants, elderly and patients affected by chronic diseases are frequently undervaccinated and/or at risk of reduced vaccine efficacy, presenting a major health and economic burden to society. Vaccine development programs mainly focus on healthy populations; therefore, vaccination strategies are often based on data arising from healthy subjects.
Immunopotentiators In Modern Vaccines
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Author : Virgil Schijns
language : en
Publisher: Elsevier
Release Date : 2005-12-19
Immunopotentiators In Modern Vaccines written by Virgil Schijns and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-19 with Medical categories.
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
Characterization Of The Innate Immunity Elicited By Vaccination And Its Interactions With Adaptive Immunity Depending On Prime Boost Delay
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Author : Jean-Louis Palgen
language : en
Publisher:
Release Date : 2019
Characterization Of The Innate Immunity Elicited By Vaccination And Its Interactions With Adaptive Immunity Depending On Prime Boost Delay written by Jean-Louis Palgen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Vaccination is one of the best achievements made in public health. However, designing vaccines against complex pathogens is currently challenging. The immune system is indeed uncompletely characterized, despite large amount of accumulated knowledges. A better understanding of vaccine-induced immunity is then required to optimize vaccine design. In particular, while most vaccines require several immunizations to induce a long-lasting adaptive immune memory, little is known on the impact of the delay beween the prime inducing a primary memory and the boost restimulating it to induce a secondary memory. Also, the innate immunity induced by each immunization and shaping the adaptative immunity is poorly characterized in this vaccine context.We studied the innate immune responses in cynomolgus macaques immunized with the modified vaccinia virus Ankara, following an homologous prime-boost vaccination at two months apart. We applied mass cytometry and bioinformatic analyses to characterize the innate response induced by each immunization. We showed that prime and boost vaccination triggered distinct innate responses. Actually, prime induced late phenotypic modifications of innate cells. These phenotypic changes suggest a stronger ability to react to the boost. Moreover, reducing the delay between prime and boost to two weeks impeded the mobilization of these phenotypically modified innate cells, and qualitatively altered humoral response.In conclusion, beyond the early innate responses, these results highlight the late induction by the prime of "likely trained" innate cells. This emerging concept corresponds to the ability of innate cells to display memory features based on epigenetic modifications. This "likely training" occured not only on monocytes and NK cells, but also on dendritic cells and strikingly on neutrophils. It was deeply connected with adaptive immune memory establishment, in a prime-boost delay dependant fashion. These findings contribute to pave the way towards to the rationale design of future vaccines, via vaccine schedule optimization and harnessment of innate training.
The Vaccine Book
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Author : Barry R. Bloom
language : en
Publisher: Academic Press
Release Date : 2016-06-23
The Vaccine Book written by Barry R. Bloom and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-23 with Medical categories.
The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
