Transient Receptor Potential Trp Channels In Drug Discovery Old Concepts New Thoughts
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Transient Receptor Potential Trp Channels In Drug Discovery Old Concepts New Thoughts
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Author : Arpad Szallasi
language : en
Publisher: MDPI
Release Date : 2018-06-22
Transient Receptor Potential Trp Channels In Drug Discovery Old Concepts New Thoughts written by Arpad Szallasi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-22 with Electronic books categories.
This book is a printed edition of the Special Issue "Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts" that was published in Pharmaceuticals
Transient Receptor Potential Trp Channels In Drug Discovery Old Concepts New Thoughts
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Author : Susan M. Huang (Ed.)
language : en
Publisher:
Release Date :
Transient Receptor Potential Trp Channels In Drug Discovery Old Concepts New Thoughts written by Susan M. Huang (Ed.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Trp Channels In Drug Discovery
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Author : Arpad Szallasi
language : en
Publisher: Humana Press
Release Date : 2012-09-20
Trp Channels In Drug Discovery written by Arpad Szallasi and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-20 with Medical categories.
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and ToxicologyTM series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Trp Channels In Drug Discovery
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Author : Arpad Szallasi
language : en
Publisher: Humana Press
Release Date : 2012-10-02
Trp Channels In Drug Discovery written by Arpad Szallasi and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-02 with Medical categories.
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and ToxicologyTM series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Transient Receptor Potential Channels
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Author : Md. Shahidul Islam
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-04
Transient Receptor Potential Channels written by Md. Shahidul Islam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-04 with Medical categories.
Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.
Trp Channels
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Author : Antonio Ferrer-Montiel
language : en
Publisher: Humana Press
Release Date : 2019-06-21
Trp Channels written by Antonio Ferrer-Montiel and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-21 with Science categories.
This book aims to provide a guide to researchers on how to work with Transient Receptor Potential (TRP) channels, describing current methodologies and protocols, and highlighting the challenges ahead that will require the development of new technologies. Articles cover a wide range of techniques, from structure to function, concluding with how to best to evaluate some of the in vivo function of TRP channels, particularly in regard to their involvement in hyperalgesia and allodynia. Also, the collection describes important and inspiring available tools that are currently being used to investigate the activity of these channels in vitro and in vivo in terms of their underlying protein structure, segueing into dealing with the generation of pharmacological tools to explore their in vivo activity and their involvement in cellular signaling pathways, which may be developed into drugs to treat diseases caused by channel dysfunction or hyperactivity. Written for the highly successful Methods in Molecular Biology series, chapters include the necessary detail and implementation advice to ensure successful results in the lab. Authoritative and practical, TRP Channels: Methods and Protocols is a useful set of methodologies for scientists seeking to better understand this vital family of channels.
Mammalian Transient Receptor Potential Trp Cation Channels
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Author : Bernd Nilius
language : en
Publisher: Springer
Release Date : 2014-06-24
Mammalian Transient Receptor Potential Trp Cation Channels written by Bernd Nilius and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-24 with Medical categories.
In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Heart Physiology And Pathophysiology
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Author : Yoshihisa Kurachi
language : en
Publisher: Elsevier
Release Date : 2000-10-09
Heart Physiology And Pathophysiology written by Yoshihisa Kurachi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-09 with Science categories.
Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Trp Channels As Therapeutic Targets
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Author : Arpad Szallasi
language : en
Publisher: Academic Press
Release Date : 2015-04-09
Trp Channels As Therapeutic Targets written by Arpad Szallasi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Medical categories.
TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them
The Pancreatic Beta Cell
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Author :
language : en
Publisher: Academic Press
Release Date : 2014-02-20
The Pancreatic Beta Cell written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-20 with Medical categories.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways