Transition Metal Catalyzed Functionalization Of C H And C C Bonds

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Transition Metal Catalyzed Functionalization Of C H And C C Bonds

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Author : Yan Xu
language : en
Publisher:
Release Date : 2018

Transition Metal Catalyzed Functionalization Of C H And C C Bonds written by Yan Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

In this dissertation, the development of several novel organic synthetic methods featuring the functionalization of C-H and C-C bonds was described by using transition metal catalysis, including the Pd-catalyzed beta sp3 C-H sulfonyloxylation of alcohols, the Pd-catalyzed beta sp3 C-H arylation of free primary amines, the Pd-catalyzed alpha-arylation of cyclopentanones, the Rh-catalyzed beta sp3 C-H functionalization of ketones, and the Ir-catalyzed C-C cleavage of unstrained ketones driven by aromatization.

C H And C X Bond Functionalization

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Author : Xavi Ribas
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013

C H And C X Bond Functionalization written by Xavi Ribas and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Science categories.

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron û an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry.

Transition Metal Catalyzed Oxidative Cross Coupling Reactions

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Author : Aiwen Lei
language : en
Publisher: Springer
Release Date : 2018-12-14

Transition Metal Catalyzed Oxidative Cross Coupling Reactions written by Aiwen Lei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-14 with Science categories.

This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.

Transition Metal Catalyzed C C Bonds Formation Via Transfer Hydrogenation

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Author : Gang Wang (Ph. D.)
language : en
Publisher:
Release Date : 2017

Transition Metal Catalyzed C C Bonds Formation Via Transfer Hydrogenation written by Gang Wang (Ph. D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Redox-triggered carbonyl addition via transfer hydrogenation, which enables direct primary alcohol C-H functionalization to form C-C bond, avoids usage of premetalated reagents or discrete alcohol to aldehyde redox reactions. Moreover, step-economy could be greatly improved by site-selective transformations of polyfunctional molecules due to bypassing the need to install and remove protecting groups. However, the redox site-selective transformations still pose a significant challenge in the area of synthetic organic chemistry. Efforts have been focused on the development of iridium catalyzed transfer hydrogenative coupling reactions of primary alcohols with different allyl donors through carbonyl addition in a site-selective manner as well as ruthenium catalyzed regioselective hydrohydroxyalkylation of primary alcohols with a basic feedstock-styrene. Additionally, studies towards the total synthesis of type I polyketide natural product (+)-SCH 351448 in the most concise route is presented.

Part 1

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Author : Derek Schipper
language : en
Publisher:
Release Date : 2011

Part 1 written by Derek Schipper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Aromatic compounds categories.

Part 1: Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis. These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates. Of these processes, direct arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry. Also, alkyne hydroarylation has garnered interest because it allows for the atom-economical synthesis of functionalized alkenes directly from simple arenes and alkynes. Described in this thesis are number of advancements in these areas. First, palladium catalyzed direct arylation of azine N-oxides using synthetically important aryl triflates is described. Interesting reactivity of aryl triflates compared to aryl bromides was uncovered and exploited in the synthesis of a compound that exhibits antimalarial and antimicrobial activity. Also reported is the efficient, direct arylation enabled (formal) synthesis of six thiophene based organic electronic materials in high yields using simple starting materials. Additionally, the site-selective direct arylation of both sp2 and sp3 sites on azine N-oxide substrates is described. The arylation reactions are carried out in either a divergent manner or a sequential manner and is applied to the synthesis of the natural products, Papaverine and Crykonisine. Mechanistic investigations point towards the intimate involvement of the base in the mechanism of these reactions. Next, the rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes and arenes with excellent regioselectivity for unsymmetrically substituted alkynes. Mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity. Part 2: Access to single enantiomer compounds is a fundamental goal in organic chemistry and despite remarkable advances in enantioselective synthesis, their preparation remains a challenge. Kinetic resolution of racemic products is an important method to access enantioenriched compounds, especially when alternative methods are scarce. Described in this thesis is the resolution of tertiary and secondary alcohols, which arise from ketone and aldehyde aldol additions. The method is technically simple, easily scalable, and provides tertiary and secondary alcohols in high enantiomeric ratios. A rationale for the unique reactivity/selectivity associated with (1S,2R)-N-methylephedrine in the resolution is proposed. Organocatalysis is a rapidly developing, powerful field for the construction of enantioenriched organic molecules. Described here is a complimentary class of organocatalysis using simple aldehydes as temporary tethers to perform challenging formally intermolecular reactions at room temperature. This strategy allows for the enantioselective, intermolecular cope-type hydroamination of allylic amines with hydroxyl amines. Also, interesting catalytic reactivity for dichloromethane is revealed.

Transition Metal Catalyzed Carbene Transformations

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Author : Jianbo Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2022-05-16

Transition Metal Catalyzed Carbene Transformations written by Jianbo Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-16 with Science categories.

Presents an up-to-date overview of the rapidly growing field of carbene transformations Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area. This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer. Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.

Transition Metal Catalysis

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Author : Tom Han Hsiao Hsieh
language : en
Publisher:
Release Date : 2011

Transition Metal Catalysis written by Tom Han Hsiao Hsieh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Carbon Carbon Bond Formation

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Author : Daniela Sustac Roman
language : en
Publisher:
Release Date : 2014

Carbon Carbon Bond Formation written by Daniela Sustac Roman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Sustainable C Sp3 H Bond Functionalization

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Author : Jin Xie
language : en
Publisher: Springer
Release Date : 2016-02-29

Sustainable C Sp3 H Bond Functionalization written by Jin Xie and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-29 with Science categories.

This book highlights major achievements made in the last five years concerning sustainable C(sp3)-H bond functionalization and offers a promising and emerging tool-kit for organic synthesis. The book is divided into three chapters demonstrating key advances in C(sp3)-H bond functionalization. Chapter 1 reviews transition-metal-catalyzed C(sp3)-H bond functionalization using different directing groups, while Chapter 2 addresses the new methods of transition-metal-catalyzed and metal-free C(sp3)-H bond functionalization without directing groups, in addition to briefly highlighting redox-neutral C(sp3)-H bond functionalization. In closing, Chapter 3 examines visible-light photoredox catalysis, an emerging and highly sustainable C(sp3)-H bond functionalization strategy. The book offers an intriguing and useful reference guide for a broad readership working and/or interested in the fields of organic, organometallic, and green chemistry.

Earth Abundant Transition Metal Catalyzed Reactions

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Author :
language : en
Publisher: Academic Press
Release Date : 2024-09-01

Earth Abundant Transition Metal Catalyzed Reactions written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Science categories.

Earth-Abundant Transition Metal Catalyzed Reactions, Volume 74 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.