Translation Mechanisms And Control
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Translation Mechanisms And Control
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Author : Michael B. Mathews
language : en
Publisher:
Release Date : 2018-09-30
Translation Mechanisms And Control written by Michael B. Mathews and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-30 with Genetic translation categories.
A subject collection from Cold Spring Harbor Perspectives in Biology.
Translation Mechanisms
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Author : Jacques Lapointe
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Translation Mechanisms written by Jacques Lapointe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Science categories.
Translation Mechanisms provides investigators and graduate students with overviews of recent developments in the field of protein biosynthesis that are fuelled by the explosive and synergic growth of structural biology, genomics, and bioinformatics. The outstanding progress in our understanding of the structure, dynamics, and evolution of the prokaryotic and eukaryotic translation machinery, as well as applications in medicine and biotechnology, are described in 26 chapters covering recent discoveries on: -the subtleties of tRNA aminoacylation with natural and unnatural amino acids. -the control of mRNA stability, a key step of gene regulation. -ribosome structure and function, in the era of the atomic-crystal resolution of the ribosome. -the regulation of the biosynthesis of the translational machinery components. -the action of a variety of inhibitors of translation and the prospect for clinical studies.
Protein Translation
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Author : Eric Jan
language : en
Publisher: Biota Publishing
Release Date : 2014-05-01
Protein Translation written by Eric Jan and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-01 with Science categories.
Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections.
Advanced Course Mechanism And Control Of Translation
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Author : Advanced Course Mechanism and Control of Translation
language : en
Publisher:
Release Date : 1990
Advanced Course Mechanism And Control Of Translation written by Advanced Course Mechanism and Control of Translation and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Translational Control Of Gene Expression
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Author : Nahum Sonenberg
language : en
Publisher: CSHL Press
Release Date : 2001
Translational Control Of Gene Expression written by Nahum Sonenberg and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Gene expression categories.
Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Embo Febs Iub Advanced Course Mechanism And Control Of Translation
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Author : Advanced Course Mechanism and Control of Translation. 1990, Noordwijkerhout
language : en
Publisher:
Release Date : 1990
Embo Febs Iub Advanced Course Mechanism And Control Of Translation written by Advanced Course Mechanism and Control of Translation. 1990, Noordwijkerhout and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Evaluation Of Mrna Translation Initiation Control Mechanisms Under Cellular Stress Conditions
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Author : Ryan Alexander Coots
language : en
Publisher:
Release Date : 2016
Evaluation Of Mrna Translation Initiation Control Mechanisms Under Cellular Stress Conditions written by Ryan Alexander Coots and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Control of mRNA translation is a critical aspect of cell physiology. Translation is primarily controlled at the level of initiation, which has been studied primarily in the context of two regulatory proteins. The 4EBP-1 protein inhibits 5' cap-binding proteins known to assist in ribosome recruitment, while the eIF2[alpha] protein serves an important role in regulating availability of the ternary complex. mTORC1, the kinase of 4EBP-1, is well-known as a translational regulator. However hypophosphorylation of 4EBP-1 has only marginal effects on translation rates. GCN2, the amino acid sensing kinase of eIF2[alpha], was long thought to only sense uncharged tRNAs. However recent work has implicated GCN2 in a variety of metabolic pathways. The extent of GCN2's regulatory control had not been thoroughly evaluated within the context of translation. While both 4EBP1 and eIF2[alpha] are controlled by phosphorylation, the extent of their translational repression differs. Increased phosphorylation of eIF2[alpha] alone seems to have dramatic effects on mRNA translation during starvation, but a phosphorylation reduction on 4EBP-1 does not have as drastic an effect. To understand why eIF2[alpha] had a greater effect on translation than 4EBP-1, I used non-phosphorylatable eIF2[alpha] MEFs to probe translation inititiation. I observed i that these mutant cells have sustained translation despite decreased phosphorylation of 4EBP-1. I show that this sustained translation is cap-independent, fulfilled by m6A modifications on mRNA, and is carried out by interacting METTL3 and ABCF1 proteins. This work helps to explain why the 4EBP-1 protein has marginal effects in regulating translation initiation, and sheds light on why TOP mRNAs have a special sensitivity to mTORC1 status. To more fully understand what roles GCN2 has in translation, I conducted phosphoproteomics with GCN2 WT and KO MEFs to isolate GCN2-dependent phosphoproteins. I show that many proteins rely on GCN2 for phosphorylation changes, and several translation-related phosphoproteins undergo phosphorylation changes in response to amino acid starvation. This experiment provides researchers with a useful dataset to evaluate GCN2-dependent phosphoproteins and demonstrates that GCN2 has broader cellular effects than have been previously identified. Collectively, this thesis pushes forward our understanding of mRNA translation initiation. ii.
Translational Control In Biology And Medicine
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Author : Michael Mathews
language : en
Publisher: CSHL Press
Release Date : 2007
Translational Control In Biology And Medicine written by Michael Mathews and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Updated and broadened 3rd edition. Since the last edition was published, the structures of the bacterial and eukaryotic ribosomes have been published, adding substantially to our knowledge of the basic mechanisms of translation. Understanding of how translation is regulated, by both protein and RNA regulators, has also advanced considerable. In addition, the current manifesttion of this volume has a significant focus on the role of translational control in human development and disease.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Protein Synthesis And Translational Control
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Author : John W. B. Hershey
language : en
Publisher: Cold Spring Harbor Perspective
Release Date : 2012
Protein Synthesis And Translational Control written by John W. B. Hershey and has been published by Cold Spring Harbor Perspective this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.