Translational Cardiometabolic Genomic Medicine
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Translational Cardiometabolic Genomic Medicine
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Author : Annabelle Rodriguez-Oquendo
language : en
Publisher: Academic Press
Release Date : 2015-09-07
Translational Cardiometabolic Genomic Medicine written by Annabelle Rodriguez-Oquendo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-07 with Science categories.
Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome
Translational Research Methods For Diabetes Obesity And Cardiometabolic Drug Development
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Author : Andrew J. Krentz
language : en
Publisher: Springer
Release Date : 2014-11-29
Translational Research Methods For Diabetes Obesity And Cardiometabolic Drug Development written by Andrew J. Krentz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-29 with Medical categories.
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Nanobiosensors
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Author : Aiguo Wu
language : en
Publisher: John Wiley & Sons
Release Date : 2020-02-11
Nanobiosensors written by Aiguo Wu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-11 with Science categories.
Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.
Penguraian Mekanisme Kerja Bahan Alam Secara In Silico
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Author : Aryo Tedjo
language : en
Publisher: PENERBIT KBM INDONESIA
Release Date : 2024-04-17
Penguraian Mekanisme Kerja Bahan Alam Secara In Silico written by Aryo Tedjo and has been published by PENERBIT KBM INDONESIA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-17 with Antiques & Collectibles categories.
Bioinformatika telah menjadi kekuatan utama dalam revolusi biologi molekuler dan kedokteran modern, memungkinkan integrasi informasi biologis kompleks seperti sekuensi genetik, struktur protein, dan jalur metabolik. Aplikasi terkemuka dari bioinformatika adalah dalam pencarian obat dari bahan alam. Melalui pendekatan in silico, bioinformatika dapat memprediksi, memodelkan, dan mengoptimalkan senyawa bioaktif dari alam untuk pengembangan obat baru. Buku ini disusun untuk menjelaskan konsep dan langkah-langkah pengembangan obat dari bahan alam secara in silico. Langkah-langkah kerja meliputi penentuan marker ekspresi gen penyakit dari data transkriptomik, identifikasi hub-genes yang bertanggung jawab mengatur jalur persinyalan dan fungsi jaringan, prediksi bioaktivitas senyawa-senyawa dalam bahan alam terhadap perubahan ekspresi gen dan aktivitas protein, serta konfirmasi interaksi senyawa bioaktif dengan protein target menggunakan metode penambatan molekul (molecular docking).
Human Drug Metabolism
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Author : Michael D. Coleman
language : en
Publisher: John Wiley & Sons
Release Date : 2020-02-19
Human Drug Metabolism written by Michael D. Coleman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-19 with Science categories.
Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.
Breastfeeding And Metabolic Programming
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Author : Özlem Naciye Şahin
language : en
Publisher: Springer Nature
Release Date : 2023-09-05
Breastfeeding And Metabolic Programming written by Özlem Naciye Şahin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Medical categories.
This comprehensive and updated book focuses on breastfeeding and its long-term effects which affect health and development, providing a protective metabolic programming against chronic non-communicable diseases such as diabetes, obesity, metabolic syndrome and hypertension. All recent developments of programming effects of breastfeeding are covered in chapters that provide fundamental knowledge besides update and sophisticated information on the subject. Special focus on: Metabolic programming Neuro-developmental Programming Infections This book will benefit neonatologists, pediatricians, GPs, obstetricians, endocrinologists and all health professionals interested in this quite new and developing topic. Residents and student will appreciate the contents coverage and clarity.
Breastfeeding And Human Lactation
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Author : Karen Wambach
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2019-10-01
Breastfeeding And Human Lactation written by Karen Wambach and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Health & Fitness categories.
Breastfeeding and Human Lactation, Sixth Edition is the ultimate reference for the latest clinical techniques and research findings that direct evidence-based clinical practice for lactation consultants and specialists. It contains everything a nurse, lactation consultant, midwife, women’s health nurse practitioner, physician assistant, or Ob/Gyn needs to know about the subject. Topics include placing breastfeeding in its historical context, workplace-related issues, anatomical and biological imperatives of lactation, the prenatal and perinatal periods and concerns during the postpartum period, the mother’s health, sociocultural issues, and more vital information.
Autophagy And Cardiometabolic Diseases
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Author : Jun Ren
language : en
Publisher: Academic Press
Release Date : 2018-04-12
Autophagy And Cardiometabolic Diseases written by Jun Ren and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-12 with Medical categories.
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations
Translational Bioinformatics
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-03-06
Translational Bioinformatics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-06 with Science categories.
Translational Bioinformatics is an emerging field in the direction of biomedical research. High throughput technologies can be applied to the generated biological data to develop the vaccine and personalized medicine. This volume consists of the chapters from different stalwart of the field covering the topics such as drug development, vector engineering, vaccine development and translational genomics. Chapters covered in this volume discuss the translational research related with cancer, Alzheimer disease and cardiovascular diseases. This volume includes the chapter describing the importance of computational resources and chemoinformatics for the translational health research. How Omics studies are helping to translate the laboratory data into the development of tools which are beneficial in the clinics have been described. How translational bioinformatics helpful in plant genomics to improve the crops have also been included in this volume. This volume has a chapter which describes the secrets of resistance development and further how these resistance are associated with human infectious diseases. This volume will be useful to the early career researcher in the development of research idea and develop their methodologies in the direction of bioinformatics and it will also give the insight to translate their findings. Translational Bioinformatics Health Informatics Multi-omics
Post Genomic Cardiology
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Author : José Marín-García
language : en
Publisher: Academic Press
Release Date : 2014-05-09
Post Genomic Cardiology written by José Marín-García and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Medical categories.
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs