Transplantation Of Retinal Pigment Epithelial Cells
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Retinal Pigment Epithelial Transplantation
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Author : Devjani Lahiri-Munir
language : en
Publisher: Springer
Release Date : 1995-11-27
Retinal Pigment Epithelial Transplantation written by Devjani Lahiri-Munir and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-27 with Medical categories.
The idea of replacing diseased retinal pigment epithelium (RPE) with viable RPE grafts has been under investigation for the past decade. This book provides an overview of the entire body of work done in the field of RPE transplantation. Whether RPE transplantation can ever serve as a clinical tool is to be decided by the future, but at present clinicians and basic scientists strive to generate specific information about all facets of this problem and look forward to the possible gratification that tomorrow may bring.
Transplantation Of Retinal Pigment Epithelial Cells
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Author : Carol Lane
language : en
Publisher:
Release Date : 1990
Transplantation Of Retinal Pigment Epithelial Cells written by Carol Lane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Transplantation Of Iris Pigment Epithelial Cells To Substitute For Retinal Pigment Epithelial Cells In Age Related Macular Degeneration
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Author : Gabriele Thumann
language : en
Publisher:
Release Date : 2001
Transplantation Of Iris Pigment Epithelial Cells To Substitute For Retinal Pigment Epithelial Cells In Age Related Macular Degeneration written by Gabriele Thumann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Transplantation Of Retinal Pigment Epithelial Cells
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Author : Anne Katrine Wiencke
language : en
Publisher:
Release Date : 2001
Transplantation Of Retinal Pigment Epithelial Cells written by Anne Katrine Wiencke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
The Fate Of Transplanted Retinal Pigment Epithelial Cells And Host Immune Response In The Subretinal Space
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Author : Xiaoyan Zhang
language : en
Publisher:
Release Date : 1996
The Fate Of Transplanted Retinal Pigment Epithelial Cells And Host Immune Response In The Subretinal Space written by Xiaoyan Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Retinal Pigment Epithelium And Macular Diseases
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Author : Gabriel Coscas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Retinal Pigment Epithelium And Macular Diseases written by Gabriel Coscas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume of Documenta Ophthalmologica Proceedings Series collects the scientific papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and the 4th Meeting of the European Macula Group held in Genoa, May 29-June 1, 1996. The Symposium on Retinal Pigment Epithelium was promoted by the University Eye Clinic of Genoa as the natural continuation of the first Symposium held with great success in Genoa in 1988. The previous Meetings of the European Macula Group were held in Coimbra (1988), Crete (1989) and Athens (1994). I was greatly pleased and honoured to host the fourth congress of this distinguished Society and I am grateful to Gabriel Coscas, Jose Cunha-Vaz and George Theodossiadis, found ers of the Society, for selecting Genoa on this occasion. The two meetings integrated well in an unicuum and brought together an exceptional number of outstanding retinal specialists coming from all over the world. All the aspects of the current research concerning retinal pigment epithelial and macular diseases were covered. Several interesting presentations regarded new techniques of retinal and choroidal imaging. A full session was dedicated to the latest advances in culture and transplantation of retinal pigment epithelial cells. Age-related macular degeneration was a major subject for discussion, including new approaches to treatment. This topic was high lighted by a mini-symposium on drusen, including a series of superb lectures on classification, clinicopathological studies, indocyanine green imaging, and laser treatment for prevention of choroidal neovascularization.
Retinal Pigment Epithelial Transplantation
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Author : Devjani Lahiri-Munir
language : en
Publisher: R G Landes Company
Release Date : 1995-01-01
Retinal Pigment Epithelial Transplantation written by Devjani Lahiri-Munir and has been published by R G Landes Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-01 with Science categories.
Optimisation Of Substrate And Growth Conditions Of Retinal Pigment Epithelial Cells Destined For Transplantation
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Author : A. Ahmado
language : en
Publisher:
Release Date : 2015
Optimisation Of Substrate And Growth Conditions Of Retinal Pigment Epithelial Cells Destined For Transplantation written by A. Ahmado and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Cellular Therapies For Retinal Disease
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Author : Steven D. Schwartz
language : en
Publisher: Springer
Release Date : 2017-06-20
Cellular Therapies For Retinal Disease written by Steven D. Schwartz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Science categories.
This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
In Vitro In Vivo Evaluation
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Author : Shen Nian
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
In Vitro In Vivo Evaluation written by Shen Nian and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Medical categories.
This dissertation, "In Vitro and in Vivo Evaluation of Iris Pigment Epithelial Cells Cultured on Surface Modified Expanded-polytetrafluorethylene Substrates as a Potential Therapeutic Strategy for Retinal Degeneration" by 年申, Shen, Nian, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Retinal degenerative diseases are diseases that may severely affect vision of people at different ages. These include retinitis pigmentosa (RP) and age-related macular degeneration (AMD). The current treatments for these diseases are limited. Since dysfunction and atrophy of the RPE are the key factors in the development of retinal degenerative diseases, transplantation of healthy retinal pigment epithelial (RPE) cells might be a promising therapeutic strategy. However, homologous RPE cells may lead to host immune rejection and harvesting autologous RPE cells may cause severe complications. Autologous iris pigment epithelial (IPE) cells, which are relatively easy to obtain, possess the same embryonic origin and share similar characteristics as RPE cells. Therefore, they may be used as a substitute of RPE cells for transplantation. Increasing interests have been demonstrated with the use of substrate to support cell attachment, proliferation and differentiation, so that transplanted cells could maintain the differentiated phenotype and perform their normal functions. However, degradation of biodegradable substrates may cause the breakdown of functional cell monolayer and produce toxic byproducts. Therefore, the aim of current study is to investigate the in vitro characteristics of rat IPE cells cultured on surface modified non-degradable expanded-polytetrafluorethylene (ePTFE) substrates and host response to the substrates without cells. Primary pure IPE cells were successfully isolated from rat eyes, which provided abundant cells for subsequent experiments. IPE cells harvested from both Long Evans rats and Dark Agouti rats proliferated and reached confluence on fibronectin coated n-heptylamine modified (F-HA) ePTFE substrates. These cells exhibited cuboidal or polygonal morphology with heavy pigmentation. In addition to the typical epithelial cell morphology, rat IPE cells grown on F-HA ePTFE substrates were able to form a cell monolayer with functional formation of tight junctional complex between neighboring cells. The IPE cell monolayers also demonstrated increased phagocytosis of photoreceptor outer segments (POS) with time and expression of cellular retinylaldehyde-binding protein (CRALBP) that served an important role in the conversion of all-trans-retinal to 11-cis-retinal in visual cycle. In the in vivo study, F-HA ePTFE substrate was successfully transplanted into the subretinal space of Royal College of Surgeons (RCS) rat, which is a well-recognized animal model of retinal degeneration. The F-HA ePTFE substrate remained flat up to 4 weeks after transplantation and did not induce significant up-regulation of pro-inflammatory cytokines TNFα and IL1β as well as activation of Muller cells and astrocytes which occurred in response to retinal inflammation. In conclusion, rat IPE cells that were grown on F-HA ePTFE substrate were able to establish a monolayer with functional tight junctions and RPE-specific functions. The F-HA ePTFE substrate demonstrated good biocompatibility in the subretinal space of RCS rats. These findings provide a potential therapeutic strategy for retinal degeneration. DOI: 10.5353/th_b4979921 Subjects: Epithelial cells Retinal degeneration - Treatment