Transporters In Drug Discovery And Development
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Transporters In Drug Discovery And Development
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Author : Yurong Lai
language : en
Publisher: Woodhead Publishing
Release Date : 2014-08-22
Transporters In Drug Discovery And Development written by Yurong Lai and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-22 with Science categories.
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity
Transporters In Drug Development
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Author : Yuichi Sugiyama
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-16
Transporters In Drug Development written by Yuichi Sugiyama and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-16 with Medical categories.
Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.
Membrane Transporters In Drug Discovery And Development
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Author : Qing Yan
language : en
Publisher: Methods in Molecular Biology
Release Date : 2010-04-26
Membrane Transporters In Drug Discovery And Development written by Qing Yan and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-26 with Medical categories.
This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.
Drug Transporters
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Author : Guofeng You
language : en
Publisher: John Wiley & Sons
Release Date : 2014-07-07
Drug Transporters written by Guofeng You and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-07 with Medical categories.
This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers
Drug Transporters
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Author : Glynis Nicholls
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016
Drug Transporters written by Glynis Nicholls and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
Drug Transporters
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Author : Glynis Nicholls
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-08-16
Drug Transporters written by Glynis Nicholls and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-16 with Science categories.
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
Drug Transporters
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Author : Glynis Nicholls
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-08-17
Drug Transporters written by Glynis Nicholls and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-17 with Science categories.
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
Membrane Transporters And Channels As Targets For Drugs
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Author : Graça Soveral
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-03
Membrane Transporters And Channels As Targets For Drugs written by Graça Soveral and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-03 with categories.
Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.
Pharmacogenomics Of Human Drug Transporters
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Author : Toshihisa Ishikawa
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-11
Pharmacogenomics Of Human Drug Transporters written by Toshihisa Ishikawa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-11 with Medical categories.
Sets the foundation for safer, more effective drugtherapies With this book as their guide, readers will discover how toapply our current understanding of the pharmacogenomics of drugtransporters to advance their own drug discovery and developmentefforts. In particular, the book explains how new findings in thefield now enable researchers to more accurately predict druginteractions and adverse drug reactions. Moreover, it sets thefoundation for the development of drug therapies that are tailoredto an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as acomprehensive guide to how transporters regulate the absorption,distribution, and elimination of drugs in the body as well as howan individual's genome affects those processes. The book's eighteenchapters have been authored by a team of leading pioneers in thefield. Based on their own laboratory and clinical experience aswell as a thorough review of the literature, these authors exploreall facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and theirclinical significance Principles of altered drug transport in drug–druginteractions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of geneticpolymorphisms Clinical aspects of genetic polymorphisms in major drugtransporter genes Future research directions of drug transporter pharmacogenomicsand the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens thedoor to new drug discovery and development breakthroughs leading tosafer and more effective customized drug therapies.The book isrecommended for pharmaceutical scientists, biochemists,pharmacologists, clinicians, and genetics and genomicsresearchers.
Drug Transporters In Drug Disposition Effects And Toxicity
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Author : Xiaodong Liu
language : en
Publisher: Springer Nature
Release Date : 2019-09-30
Drug Transporters In Drug Disposition Effects And Toxicity written by Xiaodong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-30 with Medical categories.
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.