Tributa O E Meio Ambiente
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
An Lise Da Gest O Dos Res Duos S Lidos Urbanos No Brasil Sob Uma Perspectiva Tribut Ria
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Author : Ferreira,Adriano Fernandes
language : pt-BR
Publisher: Cia do eBook
Release Date : 2016-06-02
An Lise Da Gest O Dos Res Duos S Lidos Urbanos No Brasil Sob Uma Perspectiva Tribut Ria written by Ferreira,Adriano Fernandes and has been published by Cia do eBook this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-02 with Law categories.
O objetivo deste livro é proporcionar aos acadêmicos de direito um estudo completo sobre o tema, em linguagem simples, direta e acessível. Para combater a crise ambiental se desencadeou um processo legislativo que visa prevenir e proteger o meio ambiente. Apesar de importantes avanços na legislação e positivação dos princípios de Direito Ambiental, as instituições jurídicas ainda sofrem com a falta de eficácia dos instrumentos de regulação, o que impede adaptar a incerteza da sociedade de risco com os excessivos custos de controle e aplicação da lei por parte do Estado, não caminhando no mesmo ritmo que a produção de resíduos. A proposta é uma reforma fiscal ambiental viável no Brasil para garantir o desenvolvimento sustentável. Como uma possível solução para os problemas é a utilização da extrafiscalidade dos tributos, autorizada pela Constituição Federal, de modo que os tributos ambientais se mostrem como ferramentas importantes para a realização dos princípios constitucionais da legislação ambiental no Brasil e do desenvolvimento sustentável.
C Digo Do Irc E Legisla O Complementar 2015
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Author : Vida Económica
language : en
Publisher: Vida Economica Editorial
Release Date : 2015-04-14
C Digo Do Irc E Legisla O Complementar 2015 written by Vida Económica and has been published by Vida Economica Editorial this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-14 with Law categories.
Edição prática em formato de livro de bolso que inclui a Reforma do Código do IRC aprovado pelo Decreto- Lei n.º 442-B/88, de 30 de Novembro. Inclui ainda Legislação complementar: - Regime das Depreciações e Amortizações - Regime Complementar do Procedimento de Inspecção Tributária
Constitui O 1988
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Author : Brazil
language : pt-BR
Publisher:
Release Date : 1995
Constitui O 1988 written by Brazil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Constitutions categories.
Direito Ambiental Estadual O Caso Das Leis Ambientais Do Amap
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Author : Ivana Lúcia de Franco Cei
language : pt-BR
Publisher: Autografia
Release Date : 2021-06-30
Direito Ambiental Estadual O Caso Das Leis Ambientais Do Amap written by Ivana Lúcia de Franco Cei and has been published by Autografia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-30 with Law categories.
“Cada estado membro possui, diante de suas peculiaridades regionais e da realidade que abriga, uma resposta jurídica diferenciada ainda que inserta em um modelo sistêmico, integrado, limitado pelas normas de prevalência constitucional, pela sistemática organizacional do condomínio federativo formal, tudo sob o jugo dos princípios da simetria das normas estaduais ao disposto na Constituição Federal e na compatibilidade dessas mesmas regras locais, aos limites fixados em norma geral, de competência da União (art. 24, CRFB)”.
Modelo De C Digo Tributario Para Am Rica Latina
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Author : Ruth Yamile Salcedo Younes
language : es
Publisher: Universidad del Rosario
Release Date : 2010
Modelo De C Digo Tributario Para Am Rica Latina written by Ruth Yamile Salcedo Younes and has been published by Universidad del Rosario this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Taxation categories.
World Trends In Environmental Education
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Author : Ulisses Azeiteiro
language : en
Publisher: Peter Lang Publishing
Release Date : 2004
World Trends In Environmental Education written by Ulisses Azeiteiro and has been published by Peter Lang Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Education categories.
This book contains the keynote papers delivered at the First World Environmental Education Congress (FWEEC) held in Espinho, Portugal in May, 2003. The FWEEC gathered participants from 38 countries, offering an international platform for educators, scientists, researchers, scholars, politicians, technicians, activists, media and teachers to present and debate world wide issues in environmental education. The themes it deals with include environmental policies and education, media and communication, environmental activism and citizenship, local activities, sustainable agriculture and tourism, economics and sustainability, communication, evaluation techniques, teacher training and general aspects of research. The papers offer an up-dated overview of various trends related to international environmental education, including aspects of research, teaching and project based work. Due to its nature and international scope, this publication is of special interest to educators, scientists, researchers, politicians, technicians, environment activists, teachers and others, interested in the ways environmental education is seen and practiced all over the world.
Os Direitos Fundamentais Em Timor Leste
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Author : Barbara Nazareth Oliveira
language : pt-BR
Publisher: Simplíssimo Livros
Release Date : 2015-12-18
Os Direitos Fundamentais Em Timor Leste written by Barbara Nazareth Oliveira and has been published by Simplíssimo Livros this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-18 with Law categories.
Esta é uma publicação especialmente dedicada aos direitos fundamentais em Timor-Leste. Nesta obra, são abordadas questões teóricas e práticas essenciais a uma efetiva compreensão e aplicação dos direitos fundamentais. Para este efeito, recorre-se à análise da prática corrente, das leis e da jurisprudência timorenses relevantes, bem como ao estudo da doutrina emergente nesta matéria. A reflexão contida nesta publicação incorpora, ainda, de forma transversal e inequívoca, uma perspetiva dos direitos humanos assente no direito internacional. Pretende-se oferecer um instrumento pedagógico de apoio aos profissionais, estudantes e outros interessados nesta área do Direito, tão cara à própria luta de libertação timorense, tendo, ainda, o notável potencial de contribuir para o fortalecimento da proteção jurídica dos direitos fundamentais em Timor-Leste.
Women The Environment And Sustainable Development
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Author : Rosi Braidotti
language : en
Publisher: Zed Books
Release Date : 1994
Women The Environment And Sustainable Development written by Rosi Braidotti and has been published by Zed Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Business & Economics categories.
"There is a widespread perception that the development process is in a state of multiple crisis. While the notion of sustainable development is supposed to address adequately its environmental dimensions, there is still no agreed framework relating women to this new perspective. This book is an attempt to present and disentangle the various positions put forward by major actors and to clarify the political and theoretical issues that are at stake in the debates on women, the environment and sustainable development. Among the current critiques of the western model of development which the authors review are the feminist analysis of Science itself and the power relations inherent in the production of knowledge; Women, Environment and Development (WED); Alternative Development; Environmental Reformism; and Deep Ecology, Social Ecology and Ecofeminism. In traversing this important landscape of ideas, they show how they criticise the dominant developmental model at the various levels of epistemology, theory and policy. The authors also go further and put forward their own ideas as to the basic elements they consider necessary in constructing a paradigmatic shift -- emphasising such values as holism, mutuality, justice, autonomy, self-reliance, sustainability and peace. This unique work is a signally useful contribution to clarifying thinking on a topic with immense implications for all women."--Publisher's description.
The Butterfly Defect
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Author : Ian Goldin
language : en
Publisher: Princeton University Press
Release Date : 2015-10-20
The Butterfly Defect written by Ian Goldin and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-20 with Political Science categories.
How to better manage systemic risks—from cyber attacks and pandemics to financial crises and climate change—in a globalized world The Butterfly Defect addresses the widening gap between the new systemic risks generated by globalization and their effective management. It shows how the dynamics of turbo-charged globalization has the potential and power to destabilize our societies. Drawing on the latest insights from a wide variety of disciplines, Ian Goldin and Mike Mariathasan provide practical guidance for how governments, businesses, and individuals can better manage globalization and risk. Goldin and Mariathasan demonstrate that systemic risk issues are now endemic everywhere—in supply chains, pandemics, infrastructure, ecology and climate change, economics, and politics. Unless we address these concerns, they will lead to greater protectionism, xenophobia, nationalism, and, inevitably, deglobalization, rising inequality, conflict, and slower growth. The Butterfly Defect shows that mitigating uncertainty and risk in an interconnected world is an essential task for our future.