Tumor Blood Circulation

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Tumor Blood Circulation

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Author : Hans-Inge Peterson
language : en
Publisher: CRC Press
Release Date : 2020-04-15

Tumor Blood Circulation written by Hans-Inge Peterson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Medical categories.

First Published in 1979, this book offers a full, insight into the relationship between malignant tumors and blood flow. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Microcirculation In Cancer Metastasis

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Author : F. William Orr
language : en
Publisher: CRC Press
Release Date : 1991-07-25

Microcirculation In Cancer Metastasis written by F. William Orr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-07-25 with Medical categories.

Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.

Tumor Blood Supply And Metabolic Microenvironment

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Author : Peter Vaupel
language : en
Publisher:
Release Date : 1991

Tumor Blood Supply And Metabolic Microenvironment written by Peter Vaupel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Tumors categories.

Morphofunctional Aspects Of Tumor Microcirculation

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Author : Domenico Ribatti
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-29

Morphofunctional Aspects Of Tumor Microcirculation written by Domenico Ribatti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-29 with Medical categories.

This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature.

Tumor Blood Supply And Metabolic Microenvironment

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Author : P. Vaupel
language : en
Publisher: Vch Pub
Release Date : 1991-08-01

Tumor Blood Supply And Metabolic Microenvironment written by P. Vaupel and has been published by Vch Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-08-01 with categories.

Blood Perfusion And Microenvironment Of Human Tumors

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Author : Michael Molls
language : en
Publisher:
Release Date : 1998

Blood Perfusion And Microenvironment Of Human Tumors written by Michael Molls and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.

This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.

History Of Research On Tumor Angiogenesis

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Author : Domenico Ribatti
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-16

History Of Research On Tumor Angiogenesis written by Domenico Ribatti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-16 with Medical categories.

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

Modeling Tumor Vasculature

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Author : Trachette L. Jackson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-23

Modeling Tumor Vasculature written by Trachette L. Jackson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-23 with Medical categories.

To profoundly understand biology and harness its intricacies for human benefit and the mitigation of human harm requires cross-disciplinary approaches that incorporate sophisticated computational and mathematical modeling techniques. These integrative strategies are essential to achieve rapid and significant progress in issues, in health and disease, which span molecular, cellular and tissue levels. The use of mathematical models to describe various aspects of tumor growth has a very long history, dating back over six decades. Recently, however, experimental and computational advances have improved our in the understanding of how processes act at multiple scales to mediate the development of tumor vasculature and drive the advancement of cancer. This book will showcase the development and utilization of new computational and mathematical approaches to address multiscale challenges associated with tumor vascular development. In Part I: Cell Signaling and Molecular Aspects of Tumor Blood Vessel Formation, it will be come clear that mathematical modeling can help to biochemically and biomechanically phenotype one of the most important cell types involved in cancer progression: vascular endothelial cells. When subverted by the tumor modulated environment, vascular endothelial cells form a new vascular supply capable of nourishing and translocating cancer cells to other tissues. The models in Part I illustrate the importance of quantitative approaches for gaining a deeper understanding of how normal and abnormal aspects of signal integration culminate in the cell proliferation, migration, and survival decisions that result in pathological tumor angiogenesis. The focus of Part II is the angiogenesis cascade and all of its complexities. Successful angiogenesis is mediated by the intricate interplay between biochemical and biomechanical mechanisms, including cell-cell and cell-matrix interactions, cell surface receptor binding, and intracellular signal transduction. A major challenge facing the cancer research community is to integrate known information in a way that improves our understanding of the principal underpinnings driving tumor angiogenesis and that will advance efforts aimed at the development of new therapies for treating cancer. The chapters in Part II will highlight several mathematical and computational approaches for that can potentially address this challenge. While the first two thirds of the book’s chapters demonstrate how important insights can be gained by studying cell signaling and vascular morphology and function, the series of chapters in Part III: Whole Organ Modeling of Tumor Growth and Vasculature, will integrate vasculature development with tumor growth dynamics. These two processes strongly depend on one another in ways that can only be theoretically investigated by biophysical approaches that cut across several levels of biological organization and describe both the tumor and the developing vasculature as they co-evolve. The purpose of this edited volume is not to provide a comprehensive review of all modeling efforts that address tumor vascular modeling; instead, a variety of interesting and innovative mathematical modeling approaches for understanding the development and effects of tumor vasculature are highlighted in order to illustrate some of the emerging trends in the field.

Tumors Of The Heart And Great Vessels

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Author : Allen Burke
language : en
Publisher: Afip
Release Date : 1996

Tumors Of The Heart And Great Vessels written by Allen Burke and has been published by Afip this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.

Increase Of Blood Flow In Tumor Tissue And Significance At Cancer Diagnosis

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Author : Nihon Gan Chiryō Gakkai
language : en
Publisher:
Release Date :

Increase Of Blood Flow In Tumor Tissue And Significance At Cancer Diagnosis written by Nihon Gan Chiryō Gakkai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.