Tumor Microenvironment Signaling Networks In Pathophysiology And Therapeutics
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Tumor Microenvironment Signaling Networks In Pathophysiology And Therapeutics
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Author : Francesca Pirini
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-19
Tumor Microenvironment Signaling Networks In Pathophysiology And Therapeutics written by Francesca Pirini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-19 with Medical categories.
Signaling Pathways In Cancer Pathogenesis And Therapy
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Author : David A. Frank
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-12
Signaling Pathways In Cancer Pathogenesis And Therapy written by David A. Frank and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-12 with Medical categories.
In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.
Recent Advances In Pheochromocytoma And Paraganglioma Molecular Pathogenesis Clinical Impacts And Therapeutic Perspective Volume Ii
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Author : Farhadul Islam
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-15
Recent Advances In Pheochromocytoma And Paraganglioma Molecular Pathogenesis Clinical Impacts And Therapeutic Perspective Volume Ii written by Farhadul Islam and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-15 with Medical categories.
Pheochromocytoma and paraganglioma are the primary types of neuroendocrine tumors, although they are relatively rare compared to other tumors, originating from chromaffin tissue in the adrenal medulla and/or autonomic nervous system ganglia. Because they are so rare, these tumors may go undiagnosed or undetected. Associated symptoms like hypertension are disease non-specific and may not clinically present themselves due to the fact that catecholamines can convert into their biologically inactive forms in the tumor, reducing the appearance of other symptoms as well. These tumors produce excessive catecholamines, the effects of which are manifested through various cardiac-related symptoms, such as hypertension due to increased total peripheral resistance, heart attacks despite no prior history, non-cardiogenic pulmonary shock, oedema, arrhythmias, and sudden death. In addition, these tumors have been associated with pseudo-obstruction of the bowels, diabetic ketoacidosis, and multisystem crises involving lactic acidosis. The benign pheochromocytoma and paraganglioma can progress into highly malignant phenotypes many years after the initial diagnosis, though the exact mechanisms of this are poorly understood. These tumors are considered the most familial in humans, with 25% of such tumors being hereditary, and contain mutations in twenty-nine associated genes. Thus the genetic factors causing them are highly diverse, making them extremely heterogenic. This Research Topic aims to present recent advances in Pheochromocytoma and Paraganglioma through our understanding of the underlying molecular and genetic spectrum of pheochromocytoma and paraganglioma and their clinical applications, which could provide a better understanding of the disease, improve the clinical impacts/diagnosis, and therapeutics. We welcome reviews, original research, methods, as well as perspective articles.
Comprehensive Insights Into Ampullary Cancer From Pathogenesis To Patient Centered Care
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2024-09-29
Comprehensive Insights Into Ampullary Cancer From Pathogenesis To Patient Centered Care written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-29 with Medical categories.
Delve into the intricate world of ampullary cancer with our comprehensive treatise, 'Comprehensive Insights into Ampullary Cancer: From Pathogenesis to Patient-Centered Care.' This meticulously crafted exploration offers a deep and holistic understanding of ampullary cancer, a complex malignancy originating at the junction of the common bile duct and the pancreatic duct. The treatise begins by defining and classifying ampullary cancer, providing a solid foundation for readers. Epidemiology and incidence are thoroughly examined, shedding light on the prevalence and distribution of this rare but clinically significant disease. As we navigate through the chapters, attention is devoted to unraveling the intricate web of risk factors, genetic predispositions, and the clinical presentation of ampullary cancer. Embarking on a journey into the anatomy and biochemistry of ampullary cancer, readers gain insights into morphological structures, functional significance, blood supply, lymphatic drainage, neural innervation, and the role of the ampulla in digestive processes. The treatise then delves into the cellular pathways, genetic mutations, tumor microenvironment, immune system interactions, and the role of inflammation in ampullary cancer progression.
Nitric Oxide And Cancer Pathogenesis And Therapy
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Author : Benjamin Bonavida
language : en
Publisher: Springer
Release Date : 2015-05-12
Nitric Oxide And Cancer Pathogenesis And Therapy written by Benjamin Bonavida and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-12 with Medical categories.
Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.
Cancer Stem Cells And Cancer Therapy
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Author : Rasime Kalkan
language : en
Publisher: Springer Nature
Release Date : 2024-12-31
Cancer Stem Cells And Cancer Therapy written by Rasime Kalkan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-31 with Medical categories.
This book explores the importance of cancer stem cells and their usage. Cancer is a serious health issue that affects people all over the world. Numerous studies back up the theory that stem cells play a role in cancer development. The population of cancer stem cells (CSCs) exhibits tumorigenic potential and possesses stem cell-specific markers and characteristics, such as self-renewal/proliferation and differentiation. Carcinogenesis may be significantly influenced by CSCs. Currently, treatment techniques concentrate on eliminating the CSC subpopulation using various methods, such as bypassing CSC resistance mechanisms or focussing on important biochemical pathways that govern these cells. New approaches are still required even though the negative effects of current treatment approaches are minimal. The information that has been gathered on the stem cell theory of carcinogenesis, the impact of dysregulated stem cell self-renewal on cancer transformation, and the functions of CSCs in cancer treatment are presented in this book. We also discuss how a deeper comprehension of the biology, behaviour, and environment of CSCs can advance the use of these cells in cancer therapy and lead to the development of more potent cancer treatment plans. Given its scope, Cancer Stem Cells and Cancer Therapy is an indispensable resource not only for researchers working in the field of human biology and cancer research but also for advanced students seeking an introduction to cancer stem cells and their therapeutic usage.
Liver Cancer Pathophysiology Diagnosis And Therapeutic Innovations
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-02-19
Liver Cancer Pathophysiology Diagnosis And Therapeutic Innovations written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-19 with Medical categories.
"Liver Cancer: Pathophysiology, Diagnosis, and Therapeutic Innovations" is an authoritative treatise that delves deep into the complexities of liver cancer. This comprehensive guide covers the latest in liver cancer pathophysiology, including genetic mutations, epigenetic modifications, and the role of hepatic regeneration. It offers an in-depth exploration of advanced diagnostic techniques, from imaging modalities like CT and MRI to cutting-edge biomarkers and liquid biopsies. The treatise also highlights the evolution of therapeutic strategies, including surgical interventions, local therapies, systemic treatments, and emerging immunotherapies. Special emphasis is placed on nutritional considerations and metabolic support, ensuring a holistic approach to patient care. Essential for clinicians, researchers, and students, this treatise provides a thorough understanding of liver cancer, its management, and future directions in research and treatment. Ideal for those seeking to stay at the forefront of liver cancer care and innovation.
Roles Of Nf B In Cancer And Their Therapeutic Approaches
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Author : Véronique Baud
language : en
Publisher: MDPI
Release Date : 2018-08-15
Roles Of Nf B In Cancer And Their Therapeutic Approaches written by Véronique Baud and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-15 with Science categories.
This book is a printed edition of the Special Issue "Roles of NF-κB in Cancer and Their Therapeutic Approaches" that was published in Biomedicines
Kidney Cancer Comprehensive Insights Into Pathophysiology Diagnosis And Therapeutic Strategies
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-02-19
Kidney Cancer Comprehensive Insights Into Pathophysiology Diagnosis And Therapeutic Strategies written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-19 with Medical categories.
Kidney Cancer: Comprehensive Insights into Pathophysiology, Diagnosis, and Therapeutic Strategies provides an in-depth exploration of renal cell carcinoma, offering vital information for medical professionals and researchers. This treatise delves into the complex pathophysiology of kidney cancer, examining the molecular and genetic underpinnings that drive tumor development. It also covers advanced diagnostic techniques, including imaging and biomarkers, crucial for accurate staging and effective treatment planning. The book details current therapeutic strategies, from surgical interventions to targeted and systemic therapies, with a focus on optimizing patient outcomes. With comprehensive coverage of kidney cancer's clinical management and emerging research, this resource is essential for understanding the latest advancements and improving patient care. Ideal for oncologists, nephrologists, and researchers, this treatise combines detailed scientific insights with practical guidance for clinical application.
Cancer Pathogenesis Molecular And Cellular Mechanisms Of Tumor Evolution Therapy Resistance And Immune Evasion
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Author : Sambhavi Animesh
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-24
Cancer Pathogenesis Molecular And Cellular Mechanisms Of Tumor Evolution Therapy Resistance And Immune Evasion written by Sambhavi Animesh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-24 with Science categories.
Cancer pathogenesis is a pathophysiological understanding of how molecular and cellular events play a causal role in transforming tumors from benign to malignant state. This often involves genetic, epigenetic, proteomic and metabolic alterations within solid tumors and blood cells. Besides cell intrinsic factors, tumors are also composed of stromal fibroblasts, blood vessel and immune cells that are also implicated in tumor progression. Immune evasion is another critical step of the cancer progression, wherein tumor cells modulate host immune system to escape from getting destroyed. Additionally, stemness in cancer cells is another acquired intrinsic ability of self-renewal, differentiation, heterogeneity and survival. Such properties give an edge to the tumors to maintain malignancy and confers treatment resistance. Most anti-cancer therapies that trigger cell death, senescence and/or dormancy and may backfire into maladaptive responses that lead to therapy resistance and promote tumor progression. Together these highlight the most challenging issues of cancer pathogenesis. This Research Topic aims to summarize the cutting-edge research for the broader understanding of the molecular and cellular determinants involved in cancer initiation and progression, and their impact on the anti-tumor therapies and immune evasion. In summary, this topic will help researchers to gain a more comprehensive understanding of the cancer pathogenesis, which can be used further in the development of novel therapies.