Uma Embaixada E Vingan A
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Uma Embaixada E Vingan A
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Author : Artur Azevedo
language : pt-BR
Publisher: Pop Stories
Release Date : 2023-08-25
Uma Embaixada E Vingan A written by Artur Azevedo and has been published by Pop Stories this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-25 with Fiction categories.
Em "Uma embaixada", conta-se como o tímido Minervino viu esvaziar-se o desejo que tinha de casar com a viúva Perkins, ao pedir ao amigo Salema que fizesse o pedido de noivado em seu nome. Em "Vingança", a atriz D'Arbois trai o marido, comendador Cardoso, e é alvo de uma singular vingança de sua parte.
Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Cypherpunks
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Author : Julian Assange
language : en
Publisher:
Release Date : 2016-10
Cypherpunks written by Julian Assange and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10 with Computers categories.
The Internet has led to revolutions across the world but a crackdown is now in full swing. As whole societies move online, mass surveillance programs are being deployed globally. Our civilization has reached a crossroads. In one direction lies a future promoting "privacy for the weak and transparency for the powerful"; in the other is an internet that transfers power over entire populations to an unaccountable complex of spy agencies and their trans-national corporate allies. Cypherpunks are activists who advocate the mass use of strong cryptography as a way protecting our basic freedoms against this onslaught. Julian Assange, the editor-in-chief of an visionary behind Wikileaks, has been a leading voice in the cypherpunk movement since the 1990s. Now, in a timely and important new book, Assange brings together a group of rebel thinkers and activists from the front line of the battle for cyberspace to discuss whether the internet will emancipate or enslave all of us.--
O Velho Lima E Outras Hist Rias
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Author : Artur Azevedo
language : pt-BR
Publisher: Pop Stories
Release Date : 2023-08-25
O Velho Lima E Outras Hist Rias written by Artur Azevedo and has been published by Pop Stories this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-25 with Fiction categories.
O conto "O velho Lima" é marcado pelo humor: o protagonista adoece às vésperas da Proclamação da República e, passados oito dias, volta às atividades sem ter lido um jornal sequer! Em "A réclame", o comendador Viana, sem querer, empurra a esposa Laura para os braços do poeta Passos Nogueira, porque fala dele o tempo todo. Por fim, em "A Dona Branca", o leitor encontra uma história de adultério contada com o humor característico de Artur Azevedo.
Vingan A Cruzada
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Author : Maria Lúcia Amorim
language : pt-BR
Publisher: Celso Macedo Possas Junior MEI - Editora Itapuca
Release Date : 2018-03-26
Vingan A Cruzada written by Maria Lúcia Amorim and has been published by Celso Macedo Possas Junior MEI - Editora Itapuca this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-26 with Fiction categories.
Terroristas planejam um atentado de grandes proporções na França. Uma ameaça à vida do Presidente dos Estados Unidos. Gêmeas, fisicamente idênticas, mas com temperamentos bem distintos. Elas nem imaginam que estão no centro de uma conspiração. Um homem cego pelo desejo de vingança, envolvido com um grupo terrorista. Um jornalista brasileiro, um agente da CIA e um policial dividido entre o dever e o ódio. Personagens fortes e apaixonados. Planos de vingança e assassinato entrelaçados em uma caçada internacional por França, Israel, Estados Unidos e Brasil. As histórias se cruzam em uma teia de traição e suspense contínuo.
Prophecy
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Author : S. J. Parris
language : en
Publisher: Penguin Books Canada
Release Date : 2011-06-07
Prophecy written by S. J. Parris and has been published by Penguin Books Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-07 with Astrology categories.
S. J. Parris returns with the next Giordano Bruno mystery, set inside Queen Elizabeth's palace and steeped in period atmospherics and the strange workings of the occult. It is the year of the Great Conjunction, when the two most powerful planets, Jupiter and Saturn, align--an astrologi-cal phenomenon that occurs once every thousand years and heralds the death of one age and the dawn of another. The streets of London are abuzz with predictions of horrific events to come, possibly even the death of Queen Elizabeth. When several of the queen's maids of honor are found dead, rumors of black magic abound. Elizabeth calls upon her personal astrologer, John Dee, and Giordano Bruno to solve the crimes. While Dee turns to a mysterious medium claiming knowledge of the murders, Bruno fears that some-thing far more sinister is at work. But even as the climate of fear at the palace intensifies, the queen refuses to believe that the killer could be someone within her own court. Bruno must play a dangerous game: can he allow the plot to progress far enough to give the queen the proof she needs without putting her, England, or his own life in danger? In this utterly gripping and gorgeously written novel, S. J. Parris has proven herself the new master of the historical thriller. "From the Hardcover edition."
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Processos E Julgamentos Pol Micos De S Crates A Lula Justi A Pol Tica Ou Vingan A
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Author : Edson Simões
language : pt-BR
Publisher: Editora Contracorrente
Release Date : 2023-10-17
Processos E Julgamentos Pol Micos De S Crates A Lula Justi A Pol Tica Ou Vingan A written by Edson Simões and has been published by Editora Contracorrente this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-17 with Social Science categories.
A Editora Contracorrente tem a satisfação de anunciar a publicação do livro Processos e julgamentos polêmicos, de Sócrates a Lula: justiça, política ou vingança?, de autoria de Edson Simões. Com uma abordagem inovadora e comprometida, o jurista apresenta uma obra erudita e esclarecedora. O autor mergulha nas complexidades da justiça ao longo dos tempos, em uma análise que vai além do mero estudo formal do processo. O autor conduz os leitores por julgamentos históricos, desde o século V a.C. até os desdobramentos da notória "Operação Lava Jato" e o polêmico caso Lula. Nessa jornada revela como as decisões judiciais podem influenciar o tecido social e político, abrindo espaço para debates instigantes sobre justiça, política e vingança. Além de expor a relação entre o Estado Democrático de Direito e a realização da justiça, o autor desvela a ameaça da exceção em nosso contexto atual, em que medidas excepcionais, não declaradas, minam os direitos fundamentais e a própria democracia constitucional. Com análises profundas, a obra constitui um antídoto contra a fragilização dos direitos fundamentais e os desafios contemporâneos da democracia. Dentro de sua vasta produção científica, o autor adiciona uma poderosa contribuição ao tema das farsas processuais, tornando esse livro uma leitura indispensável para todos que desejam compreender a relação intrincada entre Justiça, política e vingança. É uma obra marcante que desafia o leitor a questionar, refletir e se aprofundar nos intricados caminhos da história da Justiça e seus desafios atuais.
A Vingan A De Malik
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Author : Les Haswell
language : pt-BR
Publisher: Next Chapter
Release Date : 2023-05-17
A Vingan A De Malik written by Les Haswell and has been published by Next Chapter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Fiction categories.
Alan Brodie, um ex-agente das Forças Especiais altamente condecorado do exército britânico, é um assassino treinado com vasta experiência em operações secretas nos campos de batalha mortais do Iraque, Afeganistão e outras zonas de guerra negáveis. Aposentado do serviço militar e agora trabalhando no setor de segurança privada, Brodie acaba de fechar um acordo para comprar um bar/restaurante à beira-mar na região de Almeria, na Espanha. Desconhecido para Brodie, o proprietário anterior estava sendo coagido por um implacável cartel de drogas a permitir que suas instalações fossem usadas como um ponto de distribuição disfarçado para seu comércio ilegal e parece que eles não aceitarão um 'não' como resposta. Então eles ficam cara a cara com o assassino profissional que é Alan Brodie. Ao tomar posse do bar, Brodie é persuadido pelo chefe de polícia local Comisário Moreno a ajudá-lo a prender esses traficantes, Moreno insistindo que ele trabalhe com a bela e enigmática sargento Anita Malik, mas ninguém está preparado para a explosão de violência que Brodie desencadeia no implacável cartel. Enquanto Brodie e Malik trabalham juntos para se infiltrar e quebrar o cartel de drogas, eles se tornam próximos, mas a sedutora Sargento Malik é tudo o que ela parece?
When Google Met Wikileaks
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Author : Julian Assange
language : en
Publisher:
Release Date : 2016-10-11
When Google Met Wikileaks written by Julian Assange and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-11 with Computers categories.
In June 2011, Julian Assange received an unusual visitor: the chairman of Google, Eric Schmidt, arrived from America at Ellingham Hall, the country residence in Norfolk, England where Assange was living under house arrest. For several hours the besieged leader of the world's most famous insurgent publishing organization and the billionaire head of the world's largest information empire locked horns. The two men debated the political problems faced by society, and the technological solutions engendered by the global network--from the Arab Spring to Bitcoin. They outlined radically opposing perspectives: for Assange, the liberating power of the Internet is based on its freedom and statelessness.For Schmidt, emancipation is at one with US foreign policy objectives and is driven by connecting non-Western countries to American companies and markets. These differences embodied a tug-of-war over the Internet's future that has only gathered force subsequently. When Google Met WikiLeaks presents the story of Assange and Schmidt's encounter. Both fascinating and alarming, it contains an edited transcript of their conversation and extensive, new material, written by Assange specifically for this book, providing the best available summary of his vision for the future of the Internet.
