Understanding Drug Release And Absorption Mechanisms
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Understanding Drug Release And Absorption Mechanisms
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Author : Mario Grassi
language : en
Publisher: CRC Press
Release Date : 2006-12-26
Understanding Drug Release And Absorption Mechanisms written by Mario Grassi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-26 with Medical categories.
Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Under
Understanding Drug Release And Absorption Mechanisms
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Author :
language : en
Publisher: CRC Press
Release Date : 2007
Understanding Drug Release And Absorption Mechanisms written by and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release. Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes. Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.
Fundamentals And Applications Of Controlled Release Drug Delivery
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Author : Juergen Siepmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-15
Fundamentals And Applications Of Controlled Release Drug Delivery written by Juergen Siepmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-15 with Medical categories.
This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.
Strategies To Modify The Drug Release From Pharmaceutical Systems
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Author : Marcos Luciano Bruschi
language : en
Publisher: Woodhead Publishing
Release Date : 2015-06-16
Strategies To Modify The Drug Release From Pharmaceutical Systems written by Marcos Luciano Bruschi and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-16 with Medical categories.
Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. - Addresses the principles, systems, applications and advances in the field of drug delivery - Highlights the mathematical and physicochemical principles related to strategies - Discusses drug release and its possible modifications
Adme Processes In Pharmaceutical Sciences
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Author : Alan Talevi
language : en
Publisher: Springer
Release Date : 2018-11-30
Adme Processes In Pharmaceutical Sciences written by Alan Talevi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-30 with Medical categories.
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.
Drug Delivery Strategies For Poorly Water Soluble Drugs
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Author : Dionysios Douroumis
language : en
Publisher: John Wiley & Sons
Release Date : 2012-12-19
Drug Delivery Strategies For Poorly Water Soluble Drugs written by Dionysios Douroumis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-19 with Science categories.
Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
Mathematical Methods In Chemical And Biological Engineering
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Author : Binay Kanti Dutta
language : en
Publisher: CRC Press
Release Date : 2016-11-03
Mathematical Methods In Chemical And Biological Engineering written by Binay Kanti Dutta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Mathematics categories.
Mathematical Methods in Chemical and Biological Engineering describes basic to moderately advanced mathematical techniques useful for shaping the model-based analysis of chemical and biological engineering systems. Covering an ideal balance of basic mathematical principles and applications to physico-chemical problems, this book presents examples drawn from recent scientific and technical literature on chemical engineering, biological and biomedical engineering, food processing, and a variety of diffusional problems to demonstrate the real-world value of the mathematical methods. Emphasis is placed on the background and physical understanding of the problems to prepare students for future challenging and innovative applications.
Drug Delivery Systems
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Author : Mr. Kameswara Rao Sankula
language : en
Publisher: JEC PUBLICATION
Release Date :
Drug Delivery Systems written by Mr. Kameswara Rao Sankula and has been published by JEC PUBLICATION this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
Drug delivery systems play a crucial role in modern medicine by facilitating the targeted delivery of therapeutic agents to specific sites in the body. The development of effective drug delivery systems has revolutionized the field of pharmacotherapy, offering solutions to enhance drug efficacy, improve patient compliance, and minimize adverse effects. As the understanding of disease mechanisms and drug interactions has advanced, so too has the demand for innovative drug delivery technologies. From traditional oral medications to sophisticated nanotechnology-based platforms, drug delivery systems continue to evolve, driven by the pursuit of safer, more effective treatments. In this comprehensive textbook on drug delivery systems, we explore the principles, mechanisms, and applications of various delivery modalities. Beginning with fundamental concepts in pharmacokinetics and drug targeting, we delve into the design and formulation of drug delivery vehicles, including liposomes, nanoparticles, microspheres, and implants. Through detailed discussions and case studies, we examine the challenges and opportunities associated with each delivery system, exploring their potential applications across a range of therapeutic areas. We also explore emerging trends in drug delivery, such as personalized medicine, gene therapy, and controlled-release technologies, highlighting their potential to transform the landscape of healthcare.
Drug Delivery Systems Principles Innovations In Pharmaceutical Formulations
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Author : Mr. Darshan Lalwani
language : en
Publisher: RK Publication
Release Date : 2024-10-09
Drug Delivery Systems Principles Innovations In Pharmaceutical Formulations written by Mr. Darshan Lalwani and has been published by RK Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-09 with Business & Economics categories.
The book, explores the evolution, types, and current trends in drug delivery. It covers foundational concepts of drug delivery systems (DDS), focusing on techniques designed to maximize therapeutic efficacy and patient compliance. Through in-depth discussions on diverse delivery methods such as oral, transdermal, and nanotechnology-based systems, the book examines the challenges and innovations in targeting specific cells and sustaining drug release. With special emphasis on case studies, personalized medicine, and ethical considerations, it also highlights regulatory guidelines and future directions for drug delivery in modern healthcare. This comprehensive guide serves as a crucial resource for professionals in pharmaceutical science, providing insights into the advancements and complexities of DDS technology in optimizing patient outcomes.
Transmucosal Absorption Enhancers In The Drug Delivery Field
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Author : Luca Casettari
language : en
Publisher: MDPI
Release Date : 2020-01-07
Transmucosal Absorption Enhancers In The Drug Delivery Field written by Luca Casettari and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Medical categories.
Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.