Understanding Genomic And Hereditary Cancer Risk
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Understanding Genomic And Hereditary Cancer Risk
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Author : Suzanne M. Mahon
language : en
Publisher:
Release Date : 2021
Understanding Genomic And Hereditary Cancer Risk written by Suzanne M. Mahon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cancer categories.
"Collecting a family medical history is a regular component of the nursing assessment process that often includes information on familial cancer diagnoses, and patients may fear that they or their loved ones might be at increased risk for developing cancer because of hereditary factors. Although true inherited risk for developing cancer is much less common than acquired risk for developing cancer, approximately 10% of cancer diagnoses can be attributed to inherited risk. The identification of families exhibiting hereditary cancer syndromes enables individuals at risk to engage in increased surveillance and, in some cases, risk-reducing surgery and other preventive measures, which ultimately lead to decreasing the morbidity and mortality associated with a cancer diagnosis. The role of the nurse in helping patients to understand and manage hereditary cancer risk requires specialized knowledge of genetics and genomics concepts. Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses provides background on basic genetic and genomic concepts, particularly those related to hereditary risk for developing cancer, to aid nurses in knowing when and why to refer patients. It also provides reliable information about how and why genetic and genomic testing can both aid in treatment decisions and also guide recommendations for cancer prevention and early detection. The nurse's role in genetic testing and counseling are discussed, as are questions and answers about types of testing, including direct-to-consumer genetic testing. Following genetic testing, most genetics professionals provide detailed information about recommendations for care, including recommendations for ongoing prevention and early detection. For patients who are found to have a harmful mutation, these recommendations can be extensive and are based on the personal and family medical history, as well as the specific variant. This book provides quick overviews of many of the more common hereditary variants as well as resources for more information. This handbook provides nurses with the essentials to understand genomic and hereditary cancer risk, to assist in facilitating interprofessional care with genetics and other oncology professionals, and to provide their patients with accurate and reassuring information"--
Principles Of Clinical Cancer Genetics
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Author : Daniel C. Chung
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-20
Principles Of Clinical Cancer Genetics written by Daniel C. Chung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-20 with Medical categories.
Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
Genetics For Health Professionals In Cancer Care
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Author : Chris Jacobs
language : en
Publisher: OUP Oxford
Release Date : 2014-08-14
Genetics For Health Professionals In Cancer Care written by Chris Jacobs and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-14 with Medical categories.
The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.
Cancer Genomics For The Clinician
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Author : Ramaswamy Govindan, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2019-01-28
Cancer Genomics For The Clinician written by Ramaswamy Govindan, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Medical categories.
Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook
The Role Of Genetics In Breast And Reproductive Cancers
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Author : Piri Welcsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-03
The Role Of Genetics In Breast And Reproductive Cancers written by Piri Welcsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-03 with Medical categories.
This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.
A Guide To Cancer Genetics In Clinical Practice
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Author : Sue Clark,
language : en
Publisher: tfm Publishing Limited
Release Date : 2009-05-01
A Guide To Cancer Genetics In Clinical Practice written by Sue Clark, and has been published by tfm Publishing Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-01 with Medical categories.
FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.
Understand Your Dna A Guide
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Author : Folkersen Lasse
language : en
Publisher: World Scientific
Release Date : 2018-09-14
Understand Your Dna A Guide written by Folkersen Lasse and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-14 with Medical categories.
Are you considering to test your own DNA? Do you want to learn more about your health and ancestry? Understand your DNA — A Guide is about what you can use genetics for. For a few hundred dollars, you can now scan your own genes. Millions of people all over the world have already done so. Everyone wants to see what they can get to know about themselves, and the market growing rapidly. But what does it require from you? And what can you really use a DNA test for? Understand your DNA — A Guide helps you put the plots and charts of consumer genetics into perspective and enables you to figure out what's up and down in the media headlines. The book is also a key input for today's debate about what we as a society can and want to do with medical genetics. Genetics will play a growing role in the future. Understand your DNA — A Guide is an easy-to-read and necessary guide to that future. The book is provided with a foreword by Professor Sham Pak-Chung of Hong Kong University.While there are many books about genetics, they typically take the perspective of a scientist wanting to understand the molecular levels. At the same time, direct-to-consumer genetics is a booming market, with millions of people already tested. Very little has been published that will guide them for real, because the need here is more focused on medical and practical understanding, than focussed on molecules.This book therefore aims to hit that vacant spot in the market. It's a walk-through of all concepts that are necessary to understand in your own analysis. Meanwhile, it is also limited in scope to only those concepts — thus distinguishing it from broader works.The book is appropriate for the readerships in modern multi-ethnic metropolises because it mixes European and Asian examples, both from the collaboration between the author from Europe and the foreword-writer, Prof. Pak Sham of Hong Kong University. But also, because many of the examples in the book concerns differences and similarities between Asian and European ethnicities, something the author believes is a trend in time.
Unraveling The Code
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Author : Sean Harrison
language : en
Publisher: Sean P Harrison
Release Date : 2024-02-06
Unraveling The Code written by Sean Harrison and has been published by Sean P Harrison this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-06 with Antiques & Collectibles categories.
"Unraveling the Code: Decoding the Cancer Gene" is a groundbreaking exploration of cancer genetics's intricate and complex world, written by a team of leading scientists and medical experts. This comprehensive book takes readers on a captivating journey through the cutting-edge research, discoveries, and innovations that have revolutionized our understanding of cancer at the genetic level. This book's heart is the quest to decode the intricate genetic blueprint underlying cancer. The authors dive deep into the molecular mechanisms and genetic mutations that drive various cancer types' initiation, progression, and treatment. They explain complex concepts in a clear and accessible manner, making it an engaging read for both medical professionals and curious individuals with no prior background in genetics. "Unraveling the Code" is a scientific journey and a human one, as it delves into the stories of patients and families affected by cancer and the hope that genetic research brings to their lives. It emphasizes the importance of collaboration among scientists, clinicians, and patients in the fight against cancer. "Unraveling the Code: Decoding the Cancer Gene" is a groundbreaking exploration of cancer genetics's intricate and complex world, written by a team of leading scientists and medical experts. This comprehensive book takes readers on a captivating journey through the cutting-edge research, discoveries, and innovations that have revolutionized our understanding of cancer at the genetic level. This book's heart is the quest to decode the intricate genetic blueprint underlying cancer. The authors dive deep into the molecular mechanisms and genetic mutations that drive various cancer types' initiation, progression, and treatment. They explain complex concepts in a clear and accessible manner, making it an engaging read for both medical professionals and curious individuals with no prior background in genetics. "Unraveling the Code" is a scientific journey and a human one, as it delves into the stories of patients and families affected by cancer and the hope that genetic research brings to their lives. It emphasizes the importance of collaboration among scientists, clinicians, and patients in the fight against cancer.
Cancer Genetics
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Author : Boris Pasche
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-02
Cancer Genetics written by Boris Pasche and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-02 with Medical categories.
Cancer Genetics is a collection of chapters covering the key recent developments in cancer genetics which have an impact on clinical care. The target audience will be physicians and scientists who need to be apprised on the most recent developments in the field.
The Genetic Risks Of Cancer
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Author : Richard Graydon
language : en
Publisher:
Release Date : 2017-05-17
The Genetic Risks Of Cancer written by Richard Graydon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-17 with categories.
This book outlines the current understanding of the genetic basis of cancer and describes the major classes of cancer-causing genes that have relevance to clinical practice today: oncogenes, tumor suppressor genes, and DNA-damage repair genes. Oncogenes are genes, normally involved in cell growth and proliferation, that cause cancer when they are overexpressed, amplified, or mutated. Tumor suppressor genes, on the other hand, normally regulate cell growth, and only result in malignant progression when their negative regulatory controls are impaired or underexpressed. Recently, a third group of genes involved in regulating DNA repair has been implicated in hereditary human cancers. This class of DNA damage response genes shares many of the features of tumor suppressor genes. CHAPTER 2: SIGNALING PATHWAYS IN CANCERGenetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration are major divers of carcinogenesis. Proliferation, migration and apoptosis are intricate biological processes, generally controlled by biochemical responses of cells to stimuli in their extra-cellular micro-environment. Sequences of intracellular responses, referred to as signal transduction pathways, are generally initiated following binding of extracellular ligands to cell-surface receptors. Signaling cascades incorporate protein effector molecules, which comprise the larger protein complexes of intracellular communication pathways. During intra-cellular signal transduction, signals from one source are processed and passed on to another, downstream intra-cellular protein. Aberrantly functioning intracellular signal-transduction molecules are believed to result in many of the pathologic phenotypes of cancer cells.CHAPTER 3: HEREDITARY BREAST & OVARIAN CANCER One in nine American women who live to age 85 will develop breast cancer during their lifetime. Breast cancer is expected to account for 255,180 new cases and 41,070 deaths in the United States annually (American Cancer Society 2017). Only about 3000 cases of breast cancer will be diagnosed in women age 30 or younger, and about 2,190 cases are diagnosed in males each year in the United States. CHAPTER 10: GENOMIC COUNSELING AND CANCER RISK ASSESSMENTScientific and technologic advances in genomics are revolutionizing our approach to genetic counseling and testing, targeted therapy, and cancer screening and prevention, fulfilling the promise of personalized medicine. For physicians, genetic counselors, nurses, and other members of a multidisciplinary cancer care team, the future of personalized medicine is now; however, the current enthusiasm about personalized genomics follows several decades of scientific discovery and clinical translation in human genetics. TABLE OF CONTENTSCHAPTER 1... CANCER AS A GENETIC DISORDERCHAPTER 2 ... SIGNAL TRANSDUCTION PATHWAYSCHAPTER 3 ... BREAST AND OVARIAN CANCERCHAPTER 4 ... LUNG CANCERCHAPTER 5 ... COLON CANCERCHAPTER 6 ... LEUKEMIA AND LYMPHOMACHAPTER 7... PROSTATE CANCERCHAPTER 8 ... MALIGNANT MELANOMACHAPTER 9 ... RARE HEREDITARY CANCER SYNDROMESATAXIA TELANGIECTASIABIRT-HOGG-DUBE SYNDROMEBLADDER CANCERBLOOM'S SYNDROMEBRAIN TUMORSCARNEY COMPLEXCOWDEN SYNDROMEFANCONI ANEMIAHEREDITARY DIFFUSE GASTRIC CANCERGASTROINTESTINAL STROMAL TUMORSHEREDITARY PARAGANGLIONOMAJUVENILE POLYPOSIS SYNDROMEHEREDITARY LEIOMYOMATOSISLI-FRAUMENI SYNDROME MULTIPLE ENDOCRINE NEOPLASIASNEUROBLASTOMANEUROFIBROMATOSISPANCREATIC CANCERHEREDITARY PAPILLARY THYROID CANCERPEUTZ-JEGHERS SYNDROMERETINOBLASTOMATESTICULAR CANCERTUBEROUS SCLEROSIS COMPLEXVON HIPPEL-LINDAU SYNDROMEWERNER SYNDROMEWILMS TUMOR SYNDROMEXERODERMA PIGMENTOSUMETC. CHAPTER 10 ... GENOMIC COUNSELING AND CANCER RISK ASSESSMENTCHAPTER 11 ... PSYCHOLOGICAL ISSUES IN GENETIC CANCER SYNDROMESCHAPTER 12 ... ETHICAL AND LEGAL ISSUES - CANCER RISK COUNSELING