Understanding Protein Protein Interaction Networks
DOWNLOAD
Download Understanding Protein Protein Interaction Networks PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Understanding Protein Protein Interaction Networks book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Understanding Protein Protein Interaction Networks
DOWNLOAD
Author : Ariel Jaimovich
language : en
Publisher:
Release Date : 2010
Understanding Protein Protein Interaction Networks written by Ariel Jaimovich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Protein-protein interactions categories.
Towards A Better Understanding Of Protein Protein Interaction Networks
DOWNLOAD
Author : Tatiana A. Gutiérrez-Bunster
language : en
Publisher:
Release Date : 2014
Towards A Better Understanding Of Protein Protein Interaction Networks written by Tatiana A. Gutiérrez-Bunster and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Proteins participate in the majority of cellular processes. To determine the function of a protein it is not sufficient to solely know its sequence, its structure in isolation, or how it works individually. Additionally, we need to know how the protein interacts with other proteins in biological networks. This is because most of the proteins perform their main function through interactions. This thesis sets out to improve the understanding of protein-protein interaction networks (PPINs). For this, we propose three approaches: (1) Studying measures and methods used in social and complex networks. The methods, measures, and properties of social networks allow us to gain an understanding of PPINs via the comparison of different types of network families. We studied models that describe social networks to see which models are useful in describing biological networks. We investigate the similarities and differences in terms of the network community profile and centrality measures. (2) Studying PPINs and their role in evolution. We are interested in the relationship of PPINs and the evolutionary changes between species. We investigate whether the centrality measures are correlated with the variability and similarity in orthologous proteins. (3) Studying protein features that are important to evaluate, classify, and predict interactions. Interactions can be classified according to different characteristics. One characteristic is the energy (that is the attraction or repulsion of the molecules) that occurs in interacting proteins. We identify which type of energy values contributes better to predicting PPIs. We argue that the number of energetic features and their contribution to the interactions can be a key factor in predicting transient and permanent interactions.
Protein Protein Interactions And Networks
DOWNLOAD
Author : Anna Panchenko
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-04-06
Protein Protein Interactions And Networks written by Anna Panchenko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-06 with Science categories.
The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse. This comprehensive book provides a broad, thorough and multidisciplinary coverage of its field. It integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks.
Protein Interaction Networks
DOWNLOAD
Author : Rossen Donev
language : en
Publisher: Academic Press
Release Date : 2022-07-21
Protein Interaction Networks written by Rossen Donev and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-21 with Science categories.
Protein Interaction Networks, Volume 131 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Includes the latest information on protein design and structure
Protein Interaction Networks
DOWNLOAD
Author : Aidong Zhang
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-06
Protein Interaction Networks written by Aidong Zhang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-06 with Computers categories.
The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.
Biological Data Mining In Protein Interaction Networks
DOWNLOAD
Author : Li, Xiao-Li
language : en
Publisher: IGI Global
Release Date : 2009-05-31
Biological Data Mining In Protein Interaction Networks written by Li, Xiao-Li and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-31 with Technology & Engineering categories.
"The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.
Protein Protein Interaction Networks
DOWNLOAD
Author : Stefan Canzar
language : en
Publisher: Humana
Release Date : 2019-10-04
Protein Protein Interaction Networks written by Stefan Canzar and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with Science categories.
This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Algorithms For The Analysis Of Protein Interaction Networks
DOWNLOAD
Author : Rohit Singh (Ph.D.)
language : en
Publisher:
Release Date : 2012
Algorithms For The Analysis Of Protein Interaction Networks written by Rohit Singh (Ph.D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
In the decade since the human genome project, a major research trend in biology has been towards understanding the cell as a system. This interest has stemmed partly from a deeper appreciation of how important it is to understand the emergent properties of cellular systems (e.g., they seem to be the key to understanding diseases like cancer). It has also been enabled by new high-throughput techniques that have allowed us to collect new types of data at the whole-genome scale. We focus on one sub-domain of systems biology: the understanding of protein interactions. Such understanding is valuable: interactions between proteins are fundamental to many cellular processes. Over the last decade, high-throughput experimental techniques have allowed us to collect a large amount of protein-protein interaction (PPI) data for many species. A popular abstraction for representing this data is the protein interaction network: each node of the network represents a protein and an edge between two nodes represents a physical interaction between the two corresponding proteins. This abstraction has proven to be a powerful tool for understanding the systems aspects of protein interaction. We present some algorithms for the augmentation, cleanup and analysis of such protein interaction networks: 1. In many species, the coverage of known PPI data remains partial. Given two protein sequences, we describe an algorithm to predict if two proteins physically interact, using logistic regression and insights from structural biology. We also describe how our predictions may be further improved by combining with functional-genomic data. 2. We study systematic false positives in a popular experimental protocol, the Yeast 2-Hybrid method. Here, some "promiscuous" proteins may lead to many false positives. We describe a Bayesian approach to modeling and adjusting for this error. 3. Comparative analysis of PPI networks across species can provide valuable insights. We describe IsoRank, an algorithm for global network alignment of multiple PPI networks. The algorithm first constructs an eigenvalue problem that encapsulates the network and sequence similarity constraints. The solution of the problem describes a k-partite graph that is further processed to find the alignment. 4. For a given signaling network, we describe an algorithm that combines RNA-interference data with PPI data to produce hypotheses about the structure of the signaling network. Our algorithm constructs a multi-commodity flow problem that expresses the constraints described by the data and finds a sparse solution to it.
Protein Protein And Domain Domain Interactions
DOWNLOAD
Author : Pandjassarame Kangueane
language : en
Publisher: Springer
Release Date : 2018-02-16
Protein Protein And Domain Domain Interactions written by Pandjassarame Kangueane and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-16 with Medical categories.
This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
Protein Protein Interactions And Networks
DOWNLOAD
Author : Anna Panchenko
language : en
Publisher: Springer
Release Date : 2009-08-29
Protein Protein Interactions And Networks written by Anna Panchenko and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-29 with Science categories.
The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse. This comprehensive book provides a broad, thorough and multidisciplinary coverage of its field. It integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks.