Using Pet Mri To Assess Hepatic Radioembolization Of Yttrium 90 Microspheres
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Using Pet Mri To Assess Hepatic Radioembolization Of Yttrium 90 Microspheres
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Author : Nichole Millward Maughan
language : en
Publisher:
Release Date : 2017
Using Pet Mri To Assess Hepatic Radioembolization Of Yttrium 90 Microspheres written by Nichole Millward Maughan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Electronic dissertations categories.
Radioembolization of yttrium-90 (Y-90) microspheres is used to treat primary and secondary cancers in the liver. Though this therapy has existed for decades, the treatment is not well optimized from treatment planning to post-procedural assessment. Recently, there has been a surge to utilize the small positron yield from the radioactive decay of Y-90 for post-radioembolization positron emission tomography (PET) imaging of the microsphere activity distribution. These images provide promise for dosimetry assessment, identifying extrahepatic uptake and possible under-dosed lesions that may benefit from subsequent therapy. However, due to the low positron statistics and high flux of Bremsstrahlung radiation, PET imaging of Y-90 presents with its own unique set of challenges. In this work, we optimized the PET imaging acquisition and reconstruction parameters when imaging with a hybrid PET/MRI scanner to offer the most accurate images for quantitative dosimetric applications. We then tested the variability of imaging Y-90 with PET across multiple institutions in a world-wide phantom study in preparation for a multi-institutional phase I/II clinical trial. Lastly, we determined the clinical utility of using Y-90 PET-based dosimetry to predict clinical outcomes and assess how well it correlates with pre-treatment imaging.
Liver Radioembolization With 90y Microspheres
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Author : José Ignacio Bilbao
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-06-02
Liver Radioembolization With 90y Microspheres written by José Ignacio Bilbao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-02 with Medical categories.
This is the second edition of a very well received book devoted specifically to the treatment of liver tumors by radioembolization with 90Y microspheres. The success of the first edition was based on the provision of all the fundamental information required for successful use of this therapeutic modality in clinical practice. The new edition has been fully updated to cover the most recent advances and includes additional chapters on regulations and emerging trends. Detailed information is provided on the full range of relevant topics, including hepatic vascular anatomy (including variants), dosimetry, assessment of tumor response, and the results achieved using radioembolization alone and in combination with other treatments in patients with primary or metastatic disease. Complications and side-effects are also fully discussed. This book will prove immensely valuable for both beginners and practitioners.
Liver Radioembolization With 90y Microspheres
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Author : José Ignacio Bilbao
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-22
Liver Radioembolization With 90y Microspheres written by José Ignacio Bilbao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-22 with Medical categories.
This vital text for oncologists and radiotherapists provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors. Radioembolization combines embolization (intravascular deployment of particles – microspheres loaded with yttrium-90) and brachytherapy (local administration of radiotherapy), thereby allowing delivery of high doses of beta-radiation specifically to the tumoral area.
Nuclear Oncology
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Author : H. William Strauss
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-27
Nuclear Oncology written by H. William Strauss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-27 with Medical categories.
This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.
Colorectal Cancer Liver Metastases
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Author : Mauro Monteiro Correia
language : en
Publisher: Springer Nature
Release Date : 2019-12-28
Colorectal Cancer Liver Metastases written by Mauro Monteiro Correia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-28 with Medical categories.
Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.
Clinical Nuclear Medicine
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Author : Hans-Jürgen Biersack
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-03
Clinical Nuclear Medicine written by Hans-Jürgen Biersack and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-03 with Medical categories.
This work has true international scope, being a unique European/American joint venture that focuses on the state of the art in both diagnostic and therapeutic radionuclide methodology. Pertinent clinical applications are emphasized rather than attempting to cover everything included in the several large comprehensive texts available in our field. This "practical" approach should make it an essential guide to nuclear medicine physicians, technologists, students and interested clinicians alike.
Clinical Applications Of Nuclear Medicine Targeted Therapy
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Author : Emilio Bombardieri
language : en
Publisher: Springer
Release Date : 2018-03-27
Clinical Applications Of Nuclear Medicine Targeted Therapy written by Emilio Bombardieri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-27 with Medical categories.
This book offers a practical and modern update on radioisotope therapy. Clinically oriented, it provides a thorough guide to patient management, with the latest indications and procedures for the current radioisotopic treatments. It addresses the clinical problems associated with each respective pathology, discussing the management of patients (diagnosis and non-radioisotope therapy), the radiopharmaceuticals available today, and the current radioisotopic procedures. Wherever possible, information on dosimetry is included at the end of each topic, together with a list of and comments on the most recent guidelines with their recommendations for radiometabolic therapy. The book is divided into six main sections: thyroid diseases, hepatic tumors (HCC and hepatic metastases), bone metastases from prostate cancer, lymphomas, and neuroendocrine tumors. The last section is dedicated to new perspectives of radioisotope treatment. Based on contributions from of a multidisciplinary team of specialists: oncologists, surgeons, endocrinologists, hematologists, urologists, radiopharmacists and nuclear medicine physicians, it provides a comprehensive analysis of the position of radioisotope treatments among the various therapeutic options. Readers interested in targeted therapy, radiometabolic therapy, radioimmunotherapy and radiometabolic imaging will find this book both informative and insightful.
Hepato Pancreato Biliary And Transplant Surgery
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Author : Quyen D Chu
language : en
Publisher: Beaux Books Publishing, LLC
Release Date : 2018-01-08
Hepato Pancreato Biliary And Transplant Surgery written by Quyen D Chu and has been published by Beaux Books Publishing, LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-08 with Medical categories.
This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.
Hepatocellular Carcinoma
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Author : Yujin Hoshida
language : en
Publisher: Springer
Release Date : 2019-08-05
Hepatocellular Carcinoma written by Yujin Hoshida and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-05 with Medical categories.
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Technetium 99m Pharmaceuticals
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Author : Ilse Zolle
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-28
Technetium 99m Pharmaceuticals written by Ilse Zolle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-28 with Medical categories.
Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.