Vaccine Protocols
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Vaccine Protocols
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Author : Andrew P. Robinson
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Vaccine Protocols written by Andrew P. Robinson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Vaccine research and development is advancing at an unprecedented pace, with an increasing emphasis on rational design based upon a fundamental und- standing of the underlying molecular mechanisms. The aim of this volume is to provide a selection of contemporary protocols that will be useful to both novice and advanced practitioner alike. The variety of procedures required to design, develop, produce, and assess a vaccine is immense and covers aspects of ch- istry, biochemistry, molecular biology, cell biology, and immunology. No single volume can hope to cover these topics exclusively. Rather, here we attempt to provide a methods sourcebook focusing on hands-on practical advice. Comp- mentary and background information may be found in other volumes in the Me- ods in Molecular Medicine series. Of particular interest are volumes on Dendritic Cell Protocols, Interleukin Protocols, Vaccine Adjuvants, and DNA Vaccines. Since the publication of the first edition of Vaccine Protocols there have been major advances, particularly in the areas of bacterial genomics, antig- specific T-cell quantification, genetic manipulation of vaccine vectors, the h- nessing of natural molecules concerned with the regulation of immune responses, and the burgeoning field of DNA vaccinology. Hence, the extensive revision of this edition with new chapters on live viral vaccine vectors, atte- ated bacterial vectors, immunomodulators, MHC-peptide tetrameric complexes, and the identification of vaccine candidates by genomic analysis. Additionally, chapters from the first edition have been updated to accommodate state-of-t- art methods in vaccinology.
The Childhood Immunization Schedule And Safety
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2013-04-27
The Childhood Immunization Schedule And Safety written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-27 with Medical categories.
Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or diphtheria. Health care providers who vaccinate young children follow a schedule prepared by the U.S. Advisory Committee on Immunization Practices. Under the current schedule, children younger than six may receive as many as 24 immunizations by their second birthday. New vaccines undergo rigorous testing prior to receiving FDA approval; however, like all medicines and medical interventions, vaccines carry some risk. Driven largely by concerns about potential side effects, there has been a shift in some parents' attitudes toward the child immunization schedule. The Childhood Immunization Schedule and Safety identifies research approaches, methodologies, and study designs that could address questions about the safety of the current schedule. This report is the most comprehensive examination of the immunization schedule to date. The IOM authoring committee uncovered no evidence of major safety concerns associated with adherence to the childhood immunization schedule. Should signals arise that there may be need for investigation, however, the report offers a framework for conducting safety research using existing or new data collection systems.
Interferon Methods And Protocols
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Author : Daniel J. J. Carr
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Interferon Methods And Protocols written by Daniel J. J. Carr and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
A compendium of optimized methods to measure type I interferon efficacy as an antiproliferative or an antiviral agent. These cutting-edge techniques range from the simple to the highly complex and serve to illuminate the signaling cascades and the activation of enzymatic pathways prompted by interferon. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Interferon Methods and Protocols offers researchers powerful tools not only to ascertain the functions of IFN-stimulatory gene products, but also to identify additional molecular pathways that will clarify our understanding of the many biological events influenced by IFNs.
Immunization In Practice
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Author :
language : en
Publisher: World Health Organization
Release Date : 2015
Immunization In Practice written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
This practical guide contains seven modules targeted at district and health facility staff. It intends to meet the demands to improve immunization services so as to reach more infants in a sustainable way, building upon the experiences of polio eradication. It includes materials adapted from polio on planning, monitoring and use of data to improve the service, that can be used at any level. Revising the manual has been a team exercise. There are contributions from a large number of experts, organizations and institutions. This new edition has seven modules. Several new vaccines that have become more readily available and used in recent years have been added. Also the section on integration with other health interventions has been expanded as exciting opportunities and experiences have become evident in the years following the previous edition. Module 1: Target diseases and vaccines Module 2: The vaccine cold chain Module 3: Ensuring safe injections Module 4: Microplanning for reaching every community Module 5: Managing an immunization session Module 6: Monitoring and surveillance Module 7: Partnering with communities.
Naspag S Protocols For Pediatric And Adolescent Gynecology
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Author : Jane Geyer
language : en
Publisher: Springer Publishing Company
Release Date : 2020-09-23
Naspag S Protocols For Pediatric And Adolescent Gynecology written by Jane Geyer and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Medical categories.
Note to Readers: Publisher does not guarantee quality or access to any included digital components if book is purchased through a third-party seller. The first resource to focus on pediatric and adolescent gynecology from the perspective of frontline health care providers This one-of-a-kind, quick-access guide for nurses delivers current patient assessment and management information for the specialized field of pediatric and adolescent gynecology (PAG). Underscoring the need to consider the unique questions and concerns of the younger population as distinct from those of adults, this authoritative resource addresses a multitude of common PAG patient questions and chief complaints, including acute and chronic conditions and commonly prescribed medications and their potential side effects. Helping to foster sound decision-making in triage settings, chapters highlight red flags to consider. They include a list of pertinent questions to ask the patient, provide assessment directives, recommend appropriate interventions and/or delegation as needed, and describe commonly prescribed medications. Chapters also present considerations for special populations, particularly those who may be at a higher risk for gynecologic problems, medication side effects, and/or medication interactions. To facilitate ease of use, this guide is organized into chapters based on medication or chief complaint. Appendices deliver useful templates for effective telephone encounters and documentation, home care instructions post-procedure, a supply checklist for office treatments, administration and follow-up care for vaccines and injections, at-home medication instructions, and more. Key Features: Provides a unique focus on common PAG concerns for nurses and physician assistants Describes management guidelines for key complaints Organized in quick-access format with bulleted information, short paragraphs, charts and tables, and references for additional information Covers medication management and side effects Focuses extensively on hormonal contraceptive options Includes information on special pediatric populations Offers several useful Appendices with downloadable practice tools
Bacterial Vaccines
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Author : Fadil Bidmos
language : en
Publisher: Humana
Release Date : 2021-11-17
Bacterial Vaccines written by Fadil Bidmos and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-17 with Science categories.
The importance of vaccines to combat bacterial diseases cannot be overstated. Methods used in the development and testing of these vaccines are evolving rapidly as a direct consequence of the availability of advanced technologies. This volume will cover methods developed in the last decade, the usage of which are enabling the development of cheaper, cost-effective and structurally stable vaccines for global use. Chapters cover in silico analytical methods such as reverse vaccinology and machine learning; low-energy electron irradiation for the generation of inactivated bacterial vaccines; methods for assessment of OMV/GMMA quality and stability; and controlled human infection models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Bacterial Vaccines: Methods and Protocols is a valuable resource for novice and expert researchers interested in learning more about this important and constantly evolving field.
Oversight And Review Of Clinical Gene Transfer Protocols
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2014-03-27
Oversight And Review Of Clinical Gene Transfer Protocols written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-27 with Medical categories.
Gene transfer research is a rapidly advancing field that involves the introduction of a genetic sequence into a human subject for research or diagnostic purposes. Clinical gene transfer trials are subject to regulation by the U.S. Food and Drug Administration (FDA) at the federal level and to oversight by institutional review boards (IRBs) and institutional biosafety committees (IBCs) at the local level before human subjects can be enrolled. In addition, at present all researchers and institutions funded by the National Institutes of Health (NIH) are required by NIH guidelines to submit human gene transfer protocols for advisory review by the NIH Recombinant DNA Advisory Committee (RAC). Some protocols are then selected for individual review and public discussion. Oversight and Review of Clinical Gene Transfer Protocols provides an assessment of the state of existing gene transfer science and the current regulatory and policy context under which research is investigated. This report assesses whether the current oversight of individual gene transfer protocols by the RAC continues to be necessary and offers recommendations concerning the criteria the NIH should employ to determine whether individual protocols should receive public review. The focus of this report is on the standards the RAC and NIH should use in exercising its oversight function. Oversight and Review of Clinical Gene Transfer Protocols will assist not only the RAC, but also research institutions and the general public with respect to utilizing and improving existing oversight processes.
Stroke Genomics
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Author : Simon J. Read
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Stroke Genomics written by Simon J. Read and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and Reviews are twofold. First, it aims to provide the reader with cutting-edge reviews of clinical and preclinical genomics, written by leading experts in the field. In particular, the authors of certain chapters relate gene expression changes to physiological end points, such as functional imaging paradigms. Thus, a more holistic approach to gene expression is described, one in which molecular biology goes hand in hand with stroke pathophysiology. Second, detailed methods for study of the molecular biology of stroke are TM also included. Following the format of the Methods in Molecular Medicine series, these chapters will enable the reader to employ each technique without recourse to other methods texts. In its entirety, this book should provide the reader with the knowledge needed to design, execute, and interpret preclinical and clinical studies of stroke genomics.
Quantum Empathy Protocol
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Author : Raven Fisher
language : en
Publisher: Publifye AS
Release Date : 2024-09-28
Quantum Empathy Protocol written by Raven Fisher and has been published by Publifye AS this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-28 with Fiction categories.
""Quantum Empathy Protocol,"" a groundbreaking scientific advancement allows people to experience others' emotions and memories through genetic engineering. Dr. Ava Chen, the brilliant neurogeneticist behind this technology, faces an unexpected ethical dilemma when participants begin losing their sense of self. Set in a near-future world where the boundaries between individuals blur, this thought-provoking novel explores the profound implications of widespread empathy on society, relationships, and the very essence of human identity. As Ava races against time to find a solution, she must navigate a landscape where consciousness itself is in flux. The narrative delves deep into the double-edged nature of empathy, questioning the balance between human connection and individual autonomy. With its blend of hard science fiction and philosophical inquiry, this immersive tale challenges readers to contemplate the true cost of understanding others completely. Through Ava's journey, we confront the unintended consequences of manipulating the fabric of human experience, offering a unique perspective on the future of consciousness and the evolving definition of humanity.
Cartilage And Osteoarthritis
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Author : Massimo Sabatini
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Cartilage And Osteoarthritis written by Massimo Sabatini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.