Vascular Control Of Hemostasis
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Vascular Control Of Hemostasis
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Author : Victor vanHinsbergh
language : en
Publisher: CRC Press
Release Date : 1996-05-28
Vascular Control Of Hemostasis written by Victor vanHinsbergh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-28 with Medical categories.
Hemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties
Thrombin Thrombomodulin And The Control Of Hemostasis
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Author : John Charles Giddings
language : en
Publisher: R G Landes Company
Release Date : 1994-01-01
Thrombin Thrombomodulin And The Control Of Hemostasis written by John Charles Giddings and has been published by R G Landes Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.
This book reviews the physiological control of haemostasis with special reference to the roles of thrombomodulin and thrombin which both have powerful clotting activities. Recent developments have emphasized that vascular endothelial cells regulate a range of biological systems by interacting with humoral glycoproteins and with other cell types.
Mechanisms Of Vascular Disease
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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Treatment Of Ongoing Hemorrhage
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Author : Chad G. Ball
language : en
Publisher: Springer
Release Date : 2017-10-25
Treatment Of Ongoing Hemorrhage written by Chad G. Ball and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-25 with Medical categories.
This volume provides a concise yet comprehensive review of techniques for stopping ongoing hemorrhage in all areas of the body. The text discusses open surgical techniques and minimally invasive (percutaneous, endoscopic, radiologic, laparoscopic) approaches, as well as techniques appropriate to pre-hospital settings, such as “on the scene”, ambulance, and the battlefield. The techniques and tips are delivered in a detailed, yet simple and straight-forward manner so that readers are more readily able to replicate these concepts in the face of ongoing, life-threatening hemorrhage. Written by experts in the field, Treatment of Ongoing Hemorrhage: A Practical Guide is a valuable resource for surgeons, trainees, and any physician who works within the emergency department or upon critically ill patients.
An Engineering Control System Paradigm For Quantitative Understanding Of Hemostasis
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Author : Chia-Hung Tsai
language : en
Publisher:
Release Date : 2016
An Engineering Control System Paradigm For Quantitative Understanding Of Hemostasis written by Chia-Hung Tsai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Hemostasis categories.
Hemostasis is an essential physiological process whose proper function relies on the rapid formation of a blood clot in order to minimize blood loss after a vascular injury. To that end, effective hemostasis is a result of the regulation of a delicate balance between two opposite pathological conditions: hemophilia and thrombophilia. When the hemostatic response is too weak, as in the case of hemophilia, blood clot formation is delayed, causing excessive bleeding; while overactive hemostasis could lead to thrombosis where a blood vessel is completely occluded by a blood clot, a common manifestation of thrombophilia. Understanding the hemostatic process is of significant importance because of the acute danger associated with hemostatic disorders. In particular, they can lead to heart attack and stroke, two major causes of death in the world. The complete process of hemostasis consists of numerous components organized into two mutually interacting sub-processes known as primary and secondary hemostasis. To date, quantitative modeling studies of hemostasis have been restricted to a few individual components in isolation. Since in actuality these components never function in isolation, such studies provide only limited understanding of the individual components in question, not of the entire complex process. Obtaining a useful, holistic and high fidelity representation of the complete system requires a more comprehensive approach that adequately captures the full characteristics of all components and their interactions. However, because of intrinsic system complexity, a traditional modeling approach will generate an overly complex, computationally intractable, and hard-to-validate model. In this dissertation, in recognition of the defining characteristic of hemostasis as an automatic physiological control system, an engineering control system framework was used to provide a modular structure for organizing the overwhelming amount of information in hemostasis. In the case of primary hemostasis, mathematical expressions, specifically algebraic equations and ordinary differential equations, were developed to represent the biological events associated with each primary hemostasis module: biological equivalents of a sensor, controller, and actuator. These modules were then connected to form a mathematical model of primary hemostasis. An existing ordinary differential equation model of secondary hemostasis was updated and adapted to include additional recent biological findings on secondary hemostasis. The primary and secondary hemostasis models were modified to incorporate the interactions between the two subsystems before they were connected to form a comprehensive mathematical representation of hemostasis. This comprehensive model was used to simulate various physiological and pathological test cases, generating results consistent with experimental observations and known characteristics. We subsequently used the comprehensive model to study select disease conditions representative of one of the four categories of hemostatic disorders: hyperactive primary hemostasis, deficient primary hemostasis, hyperactive secondary hemostasis, and deficient secondary hemostasis. This exercise enabled us to identify new potential treatment targets that we recommend for future experimental investigations, but which include targets that are already being used as the basis for current clinical treatment strategies for hemophilia A and hemophilia B, demonstrating the effectiveness and predictive power of the comprehensive model. Finally, we carried out an experimental and simulation case study involving an actual patient with low platelet count due to immune thrombocytopenic purpura, a pathology that represents a deficiency in the primary hemostasis controller and the actuator. Using an existing model customized to describe the drug dose-response relationship in the patient, a weekly treatment frequency was found to be capable of achieving a stable platelet count, while biweekly treatment regimen always resulted in oscillations due to the pharmacological properties of the drug.
Core Topics In Vascular Anaesthesia
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Author : Carl Moores
language : en
Publisher: Cambridge University Press
Release Date : 2012-06-07
Core Topics In Vascular Anaesthesia written by Carl Moores and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-07 with Medical categories.
Vascular surgery and anaesthesia have changed considerably in recent years and become recognised subspecialties, although non-specialist anaesthetists continue to provide much of the care for emergency vascular surgical patients. Core Topics in Vascular Anaesthesia brings together the clinical expertise of global leaders in the field in a comprehensive review of contemporary practice. Detailed discussion is included on every aspect of clinical management: • Preoperative risk assessment, including cardiopulmonary exercise testing and risk modification using pharmacological and cardiac interventions • Anaesthesia for major vascular operations including carotid endarterectomy, complex endovascular aortic surgery and repair of ruptured aortic aneurysms • Intraoperative management of high risk patients including advanced monitoring techniques, fluid management, blood conservation and transfusion, major haemorrhage and treatment of coagulopathy Practical and well illustrated, Core Topics in Vascular Anaesthesia is essential reading for anaesthetists, intensive care physicians and vascular surgeons.
The Endothelium
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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Anatomy And Physiology
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Author : J. Gordon Betts
language : en
Publisher:
Release Date : 2013-04-25
Anatomy And Physiology written by J. Gordon Betts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-25 with categories.
Haemostasis In Surgery
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Author : Nadey S. Hakim
language : en
Publisher: Imperial College Press
Release Date : 2007
Haemostasis In Surgery written by Nadey S. Hakim and has been published by Imperial College Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
This unique volume presents the cutting edge of haemostasis in surgery and includes the advances in the science pertaining to related important medical and surgical problems. It is the only book that includes all the surgical subspecialties focusing specifically on the problems of haemostasis in each field. State-of-the-art laboratory and clinical reviews are included and modern devices used in the different specialties are also covered. The contributors are well-known authorities in their special fields and haematological area. Each is covered comprehensively with special emphasis on unanswered questions. The book is addressed to all surgeons and physicians with an interest in this exciting field.
The Cerebral Circulation
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Author : Marilyn J. Cipolla
language : en
Publisher: Biota Publishing
Release Date : 2016-07-28
The Cerebral Circulation written by Marilyn J. Cipolla and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-28 with Medical categories.
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.