Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231
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Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231
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Author : Brandt D. Whitehurst
language : en
Publisher:
Release Date : 2006
Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231 written by Brandt D. Whitehurst and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Metastasis significantly contributes to cancer mortality and is facilitated by lymphangiogenesis. Recent reports indicate that VEGF-A can modulate this process. We therefore evaluated VEGF-A neutralization as a potential anti-lymphangiogenic treatment in an orthotopic model of human breast cancer MDA-MB-231. Anti-VEGF-A therapy caused an 80% reduction in lymphatic vessel density and inhibited metastasis. VEGF-A neutralization decreased expression of VEGF-C by 28% in cultured MDA-MB 231 cells but not affect global VEGF-C expression in vivo. Immunofluorescent staining of lymphatic vessels demonstrated robust expression of VEGFR-3 on LYVE-1-positive vessels in control tumors. However, decreased and aberrant expression of VEGFR-3 was detected on lymphatic vessels in VEGF-A depleted tumors. RT-PCR analysis revealed three-fold decreased expression of Ang-2 in treated tumors which correlated with decreased VEGFR-3 transcript. The study demonstrates VEGF-A neutralization is a potential target for anti-metastatic therapy and identifies a novel mechanism for VEGF-A dependent modulation of lymphangiogenesis.
The Potential Effect And Mechanism Of Chinese Traditional Medicine On Vascular Homeostasis And Remodeling
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Author : Yuliang Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-02
The Potential Effect And Mechanism Of Chinese Traditional Medicine On Vascular Homeostasis And Remodeling written by Yuliang Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-02 with Science categories.
Angiogenesis Assays
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Author : Carolyn A. Staton
language : en
Publisher: John Wiley & Sons
Release Date : 2007-01-11
Angiogenesis Assays written by Carolyn A. Staton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-11 with Medical categories.
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Chemoprevention Of Cancer
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Author : Daniel W. Nixon
language : en
Publisher: CRC Press
Release Date : 1994-11-08
Chemoprevention Of Cancer written by Daniel W. Nixon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-08 with Medical categories.
Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.
Pathology Of Hepatocellular Carcinoma
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Author : Masamichi Kojiro
language : en
Publisher: John Wiley & Sons
Release Date : 2009-02-12
Pathology Of Hepatocellular Carcinoma written by Masamichi Kojiro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-12 with Medical categories.
This book covers the huge advances made in clinical diagnosisenabling earlier detection, while addressing the recent progressmade in treatment of hepatocellular carcinoma (HCC) to enablesuccessful therapy. It draws on the expertise of an internationally recognizedauthor famed for his understanding, knowledge and efforts indefining terms and diagnosis in this area. The text reviews the full range of pathological information ofHCC based on the study of surgical cases and biopsy materials,along with images, to help compare findings that may be encounteredby pathologists. It also makes special reference to developments inearly stage HCC detection and premalignant lesions which canincrease effective treatment.
Metastatic Cancer Clinical And Biological Perspectives
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Author : Rahul Jandial
language : en
Publisher: CRC Press
Release Date : 2013-08-08
Metastatic Cancer Clinical And Biological Perspectives written by Rahul Jandial and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-08 with Medical categories.
Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Tumor Vascularization
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Author : Domenico Ribatti
language : en
Publisher: Academic Press
Release Date : 2020-01-21
Tumor Vascularization written by Domenico Ribatti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-21 with Science categories.
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Handbook Of Anticancer Drugs From Marine Origin
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Author : Se-Kwon Kim
language : en
Publisher: Springer
Release Date : 2014-11-27
Handbook Of Anticancer Drugs From Marine Origin written by Se-Kwon Kim and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Science categories.
This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Breast Cancer Metastasis And Drug Resistance
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Author : Aamir Ahmad
language : en
Publisher: Springer Nature
Release Date : 2019-08-27
Breast Cancer Metastasis And Drug Resistance written by Aamir Ahmad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-27 with Medical categories.
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
Angiogenesis Inhibition
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Author : Rüdiger Liersch
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-24
Angiogenesis Inhibition written by Rüdiger Liersch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-24 with Medical categories.
Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.