Vip Pacap Glucagon And Related Peptides
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Vip Pacap Glucagon And Related Peptides
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Author : Jan Fahrenkrug
language : en
Publisher:
Release Date : 2000
Vip Pacap Glucagon And Related Peptides written by Jan Fahrenkrug and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
In this volume, an international group of experts presents research on the biology, biochemistry, molecular biology, physiology and pharmacology of the growing class of peptides that function as hormones or neurotransmitters, including vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptide (PACAP), glucagon, and related peptides. Topics include the role of this family of peptides and their receptors in signal transduction mechanisms, cancer, autonomic physiology, neurobiology, cell proliferation, cell death and tissue injury, endocrinology, and neuroimmunology, along with clinical and potential therapeutic implications.
Vip Pacap And Related Peptides
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Author : Akira Arimura
language : en
Publisher:
Release Date : 1996
Vip Pacap And Related Peptides written by Akira Arimura and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Adenylate cyclase categories.
Recent research findings on vascular intestinal peptide (VIP), pituitary adenyl cyclase activating peptide (PACAP), and other members of the secretin/glucagon family of peptides are reported by leaders in the field. The role of these peptides in the regulation of gene expression, developmental and neurotrophic processes, as well as endocrine and gastrointestinal functions are addressed and their basic clinical implications discussed.
Vip Pacap And Related Peptides
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Author : Wolf-Georg Forssmann
language : en
Publisher:
Release Date : 1998
Vip Pacap And Related Peptides written by Wolf-Georg Forssmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
In this volume of papers research findings on vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptide (PACAP), and related peptides are presented. The authors provide information on the biology, biochemistry, molecular biology, physiology, signal transduction mechanisms, and pharmacology of these peptides. Their roles in neurobiology, cell proliferation and tumorogenesis, inflammation and tissue injury, endocrinology, gastrointestinal function, and other topics are discussed, along with clinical and potential therapeutic implications.
Vasoactive Intestinal Peptides Pituitary Adenylate Cyclase Activating Polypeptide And Related Regulatory Peptides From Molecular Biology To Clinical Applications
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Author : G Rosselin
language : en
Publisher: World Scientific
Release Date : 1994-06-21
Vasoactive Intestinal Peptides Pituitary Adenylate Cyclase Activating Polypeptide And Related Regulatory Peptides From Molecular Biology To Clinical Applications written by G Rosselin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-21 with categories.
This book provides the most up-to-date information on the ever-growing class of peptides with high biological activity, which function as hormones or neurotransmitters and have analogous structures. These peptides include the Vasoactive Intestinal Peptide (VIP), the Pituitary Adenylate Cyclase-Activating Polypeptides (PACAP 38 and PACAP 27), the Peptide Histidyl-Isoleucylamide and the Histidyl-Methionine Peptide (PHI and PHM), Helodermin, Helospectin, the Growth Hormone Releasing Factor (GRF), Glucagon, the Glucagon-like Peptides I and II, Oxyntomodulin, Glicentin and Secretin.Selection, organization and special subject matter: The contributors to this volume who are leading experts in their fields, present a valuable synopsis of the significant research in the transduction of the peptide signals, and how it helps to maintain the essential environment for cellular functions and adaptation. Contributions are organized around the molecular systems involved in the normal and altered functions of the central nervous system, the endocrine systems and cellular proliferation. In addition, the book identifies potential sites to be targeted for drug design and therapeutic development in the domain of biosynthesis, inflammation and cardiovascular and digestive diseases.This book draws together information from widely-scattered literature and thus obviates the need for time-consuming research on the part of the readers. It is aimed at an international audience of pharmacologists, physiologists, clinical investigators, biochemists and researchers.
Vip Pacap And Related Peptides
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Author : Hubert Vaudry
language : en
Publisher: Wiley-Blackwell
Release Date : 2006-08-07
Vip Pacap And Related Peptides written by Hubert Vaudry and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-07 with Science categories.
This volume provides an overview on the biochemistry, physiology, and pharmacology of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and related peptides. VIP and PACAP are undoubtedly among the most fascinating neuropeptides ever identified. They belong to the largest family of regulatory peptides, which comprises several other prominent neuroendocrine peptides including secretin (the first peptide hormone that has been identified), glucagon, and growth hormone-releasing hormone. The structural and physiological relationships of these peptides as well as their receptors provide a unique model for investigating the processes of molecular evolution leading to the diversification of multigene families. The primary structures of VIP and PACAP have been remarkably well conserved across vertebrates, suggesting that these peptides must be involved in vital functions throughout the animal kingdom. Indeed, VIP and PACAP appear to be implicated in a large array of physiological processes such as development; growth; endocrine, cardiovascular, respiratory, reproductive and digestive functions; immune responses; and circadian rhythms. There is also clear evidence that VIP and PACAP exert both trophic and antiproliferative effects on normal and tumor cells. The beneficial influence of VIP and PACAP agonists and antagonists in various pathological states including heart failure, ischemia, asthma, impotence, and cancer has motivated the development of novel selective VIP or PACAP ligands that could potentially be used as antihypertensive, neuroprotective, bronchodilatory, vasodilatory, and/or antiproliferative drugs. The occurrence of multiple VIP/PACAP receptor subtypes and splice variants that exhibit tissue-specific expression and possess differential affinity for various ligands generates hopes for the development of new therapeutic agents that could act selectively on the desired target cells. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
From Structure To Clinical Development Allosteric Modulation Of G Protein Coupled Receptors
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-13
From Structure To Clinical Development Allosteric Modulation Of G Protein Coupled Receptors written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-13 with Medical categories.
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Cellular Peptide Hormone Synthesis And Secretory Pathways
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Author : Jens F. Rehfeld
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Cellular Peptide Hormone Synthesis And Secretory Pathways written by Jens F. Rehfeld and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.
Handbook Of Neuroendocrinology
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Author : George Fink
language : en
Publisher: Academic Press
Release Date : 2012
Handbook Of Neuroendocrinology written by George Fink and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Conn S Translational Neuroscience
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2016-09-28
Conn S Translational Neuroscience written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-28 with Medical categories.
Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment
Pituitary Adenylate Cyclase Activating Polypeptide Pacap
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Author : Dora Reglodi
language : en
Publisher: Springer
Release Date : 2016-10-08
Pituitary Adenylate Cyclase Activating Polypeptide Pacap written by Dora Reglodi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-08 with Medical categories.
The first comprehensive book to cover all aspects of the last 25 years of PACAP (pituitary adenylate cyclase activating polypeptide) research, this book contains contributions from virtually all the leading researchers in the field, and addresses some of the following topics: evolutionary aspects of PACAP, distribution and occurrence of PACAP and its receptors, hormonal effects of PACAP, intracellular signaling, effects on cellular proliferation and differentiation, protective effects of PACAP, behavioral effects of PACAP, developmental aspects of PACAP, other physiological effects of PACAP (cardiovascular, thermoregulatory), human studies, drug design, metabolism and transport. This compendium can serve as an important reference for researchers and students in PACAP research and can also be a thorough introduction for those in related fields.