Ways To Improve Tumor Uptake And Penetration Of Drugs Into Solid Tumors
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Ways To Improve Tumor Uptake And Penetration Of Drugs Into Solid Tumors
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Author : Fabrizio Marcucci
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-05
Ways To Improve Tumor Uptake And Penetration Of Drugs Into Solid Tumors written by Fabrizio Marcucci and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-05 with Cancer categories.
The main scope of this topic is to give an update on pharmacologic and non-pharmacologic approaches to enhance uptake and penetration of cancer drugs into tumors. Inadequate accumulation of drugs in tumors has emerged over the last decade as one of the main problems underlying therapeutic failure and drug resistance in the treatment of cancer. Insufficient drug uptake and penetration is causally related to the abnormal tumor architecture. Thus, poor vascularization, increased resistance to blood flow and impaired blood supply represent a first obstacle to the delivery of antitumor drugs to tumor tissue. Decreased or even inverted transvascular pressure gradients compromise convective delivery of drugs. Eventually, an abnormal extracellular matrix offers increased frictional resistance to tumor drug penetration. Abnormal tumor architecture also changes the biology of tumor cells, which contributes to drug resistance through several different mechanisms. The variability in vessel location and structure can make many areas of the tumor hypoxic, which causes the tumor cells to become quiescent and thereby resistant to many antitumor drugs. In addition, the abnormally long distance of part of the tumor cell population from blood vessels provides a challenge to delivering cancer drugs to these cells. We have recently proposed additional mechanisms of tumor drug resistance, which are also related to abnormal tumor architecture. First, increased interstitial fluid pressure can by itself induce drug resistance through the induction of resistance-promoting paracrine factors. Second, the interaction of drug molecules with vessel- proximal tumor cell layers may also induce the release of these factors, which can spread throughout the cancer, and induce drug resistance in tumor cells distant from blood vessels. As can be seen, abnormal tumor architecture, inadequate drug accumulation and tumor drug resistance are tightly linked phenomena, suggesting the need to normalize the tumor architecture, including blood vessels, and/or increase the accumulation of cancer drugs in tumors in order to increase therapeutic effects. Indeed, several classes of drugs (that we refer to as promoter drugs) have been described, that promote tumor uptake and penetration of antitumor drugs, including those that are vasoactive, modify the barrier function of tumor vessels, debulk tumor cells, and overcome intercellular and stromal barriers. In addition, also non-pharmacologic approaches have been described that enhance tumor accumulation of effector drugs (e.g. convection-enhanced delivery, hyperthermia, etc.). Some drugs that have already received regulatory approval (e.g. the anti-VEGF antibody bevacizumab) exert antitumor effects at least in part through normalization of the tumor vasculature and enhancement of the accumulation of effector drugs. Other drugs, acting through different mechanisms of action, are now in clinical development (e.g. NGR-TNF in phase II/III studies) and others are about to enter clinical investigation (e.g. JO-1).
Lab On A Chip Devices For Advanced Biomedicines
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Author : Arpana Parihar
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-08-14
Lab On A Chip Devices For Advanced Biomedicines written by Arpana Parihar and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-14 with Technology & Engineering categories.
The global miniature devices market is poised to surpass a valuation of $12–$15 billion USD by the year 2030. Lab-on-a-chip (LOC) devices are a vital component of this market. Comprising a network of microchannels, electrical circuits, sensors, and electrodes, LOC is a miniaturized integrated device platform used to streamline day-to-day laboratory functions, run cost-effective clinical analyses and curb the need for centralized instrumentation facilities in remote areas. Compact design, portability, ease of operation, low sample volume, short reaction time, and parallel investigation stand as the pivotal factors driving the widespread acceptance of LOC within the biomedical community. In this book, the Editors meticulously explore LOC through three key ‘Ts’: Theories (microfluidics, microarrays, instrumentation, software); Technologies (additive manufacturing, artificial intelligence, computational thinking, smart consumables, scale-up tactics, and biofouling); and Trends (biomedical analysis, point-of-care diagnostics, personalized healthcare, bioactive synthesis, disease diagnosis, and space applications) This comprehensive text not only provides readers with a thorough understanding of the current advancements in the LOC domain but also offers valuable insights to support the utilization of miniaturized devices for enhanced healthcare practices. Aimed at career researchers looking for instruction in the topic and newcomers to the area, the book is also useful for undergraduate and postgraduate students embarking on new studies or for those interested in reading about the LOC platform.
The Textbook Of Nanoneuroscience And Nanoneurosurgery
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Author : Babak Kateb
language : en
Publisher: Springer Nature
Release Date : 2024-11-13
The Textbook Of Nanoneuroscience And Nanoneurosurgery written by Babak Kateb and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-13 with Medical categories.
This textbook highlights the exciting field of nanoneuroscience and its potential to transform how we diagnose and treat neurological disorders. "The Textbook of Nanoneuroscience and Nanoneurosurgery," dives deep into this emerging field, exploring the latest tools and techniques currently being developed at the nanoscale level. Key areas of focus include: Nanoplatforms: The book explores how scientists utilize materials on a near-microscopic scale for neurosurgery, neurology, and brain imaging applications. Bridging the Gap: Regulatory hurdles for translating research from the lab to real-world use are addressed, paving the way for future advancements. The Future is Now: The book showcases recent breakthroughs already impacting patient care alongside promising areas with significant potential. Collaboration is Key: Insights from over 220 researchers and 5000+ references, along with illustrative figures in B/W and color, provide a comprehensive overview of this dynamic field. With its focus on minimally invasive procedures and the latest regulatory considerations, "The Textbook of Nanoneuroscience and Nanoneurosurgery" equips researchers and medical professionals with the knowledge to develop groundbreaking treatments for neurological conditions. The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic and the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may impact the field soon. Some reviews of the First edition of the textbook. "...a significant contribution to the field of nanoneuroscience and nanoneurosurgery ... the reader will come away with a deeper understanding of the history of nanotechnology and medicine." —Neuroscience "This is a monumental first textbook on nanoneurosurgery. ... recommended reading for neurosurgeons, neurologists, neuroradiologists, and neuroscientists involved in research on new techniques for application in neurosurgery. Biomedical engineers and various companies developing instruments and devices would benefit from the wealth of information about trends for the development of new technologies for neurosurgery." K. K. Jain, MD, Basel, Switzerland "Phenomenal body of knowledge in this book that would take eons to collate by myself. Every answer to every one of my questions plus heaps more. Essential reading for everyone interested in the field. A must-have!" Albert Deme "This is an amazing foray into the future of a largely unexplored, but increasingly critical medical domain.....I have learned much from every page of this captivating text, and I highly recommend it to any medical student, researcher, medical professional in the neurosciences, or anyone who has an interest in the human brain and the future of medicine, to gather a glimpse of the incredible and beneficial paradigm shifts that will soon impact the field of neuroscience." Frank Boehm, British Columbia, Canada
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 2007-12
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12 with Cancer categories.
Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.
Drug Resistance In Oncology
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Author : S. Bernal
language : en
Publisher: CRC Press
Release Date : 1997-08-21
Drug Resistance In Oncology written by S. Bernal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-08-21 with Medical categories.
This timely new reference integrates the latest clinical results and laboratory studies on the resistance of specific cancers to chemotherapeutic drugs-covering drug resistance in lung, breast, ovary, and colon cancer as well as hematological malignancies.
Cancer Microenvironment And Therapeutic Implications
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Author : Gianfranco Baronzio
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-10
Cancer Microenvironment And Therapeutic Implications written by Gianfranco Baronzio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-10 with Medical categories.
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
Supramolecular Assembly Based Functional Nanostructures For Biomedical Applications
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Author : Tianjiao Ji
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-26
Supramolecular Assembly Based Functional Nanostructures For Biomedical Applications written by Tianjiao Ji and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-26 with Science categories.
Photodynamic Therapy For The Management Of Disease
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Author : Rishabha Malviya
language : en
Publisher: CRC Press
Release Date : 2025-09-12
Photodynamic Therapy For The Management Of Disease written by Rishabha Malviya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-09-12 with Science categories.
Advances in medical technology have brought the use of photosensitizing materials and light for treating diverse ailments to a new level, with reduced adverse effects and enhanced therapeutic outcomes. This new book focuses on diffusion optical imaging, a non-invasive imaging technique that allows for real-time visualization of the treatment area, and explores its application for treating patients through various modes. The volume discusses photodynamic treatement for pharmacological intervention, breast cancer diagnosis using biophotonics, photothermal therapy for cancer with gold nanoparticles, photobiomodulation therapy for the brain, with a specific focus on its potential impact on neurodegenerative conditions such as Alzheimer's and Parkinson's disease, and more.
New Nanomaterials And Techniques For Tumor Targeted Systems
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Author : Rongqin Huang
language : en
Publisher: Springer Nature
Release Date : 2020-09-28
New Nanomaterials And Techniques For Tumor Targeted Systems written by Rongqin Huang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-28 with Medical categories.
This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
Nanotechnology Based Targeted Drug Delivery Systems For Lung Cancer
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Author : Prashant Kesharwani
language : en
Publisher: Academic Press
Release Date : 2019-01-26
Nanotechnology Based Targeted Drug Delivery Systems For Lung Cancer written by Prashant Kesharwani and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-26 with Medical categories.
Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. - Provides an overview of an array of nanotechnology-based drug delivery systems - Examines the design, synthesis and application of different nanocarriers in drug and gene delivery - Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers