Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity
DOWNLOAD
Download Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity
DOWNLOAD
Author : Aseel Al-Aamiri
language : en
Publisher:
Release Date : 2017
Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity written by Aseel Al-Aamiri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Axons categories.
Axon guidance is a fundamental process during animal nervous system development. For neurons to function correctly, they must be wired into their target areas. Several neurodevelopment disorders result from wiring defects. The guidance process is continuous, and outgrowth direction activity may fluctuate across the plasma membrane. We propose this process is statistically dependent. If the probability of axon outgrowth at one site changes then the probability at another site must change. The plasma membrane movement can be modeled by a random walk. Axon guidance process is regulated by many conserved extracellular guidance cues that can act as attractants or repellants, but how these guidance cues are regulated is still being researched. In Caenorhabditis elegans, the UNC-6/Netrin extracellular cue directs neuronal outgrowth. Neuronal response to UNC-6/Netrin is mediated by UNC-40/DCC and UNC-5/UNC5 receptors and the UNC-53/NAV2 cytoplasmic protein. My study provides evidence that links stochasticity with transcriptional regulation of axon guidance to regulate axon orientation at the transcriptional level. ZAG-1, a member of the ZEB family of transcription factors, affects neuronal outgrowth patterning by regulating UNC-40-mediated neuronal outgrowth activity. Understanding the functional relationship between transcription factors and the cell-surface and cytoskeletal proteins that mediate their effects is a current challenge in neurobiology. Here I present evidence that ZAG-1 and UNC-5 regulate UNC-40::GFP localization, axon outgrowth patterning, and the directional bias of axons by regulating the UNC-6/Netrin signaling pathway and UNC-53 activities. unc-5 mutations alter UNC-40::GFP asymmetric localization and axon outgrowth patterning that neurons develop. Genetic interactions suggest that UNC-5 and ZAG-1 act with UNC-53 to regulate axon outgrowth patterning and UNC-40::GFP asymmetric localization in response to extracellular guidance cues.
Hearing Impairment And Disability
DOWNLOAD
Author : Ariel Tenenbaum
language : en
Publisher:
Release Date : 2020
Hearing Impairment And Disability written by Ariel Tenenbaum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Medical categories.
"Much research has been conducted to provide researchers and hearing healthcare professionals with updated information in regard to hearing assessments, results interpretation and case management. This ongoing research is particularly imperative to guide clinicians with optimized methods in assessing and managing pediatric patients with hearing impairment and disability. As such, tremendous research efforts have been made in determining the most optimum methods in assessing hearing using both subjective and objective tests. Since hearing loss can occur due to disrupted peripheral and/or central auditory pathway, there is also a growing interest to study children with auditory processing disorder (APD). Even though notable achievements have been observed in understanding APD, more research is required, particularly in establishing a gold standard APD test and its specific interventions. Aditionally, having an objective test such as speech-evoked auditory brainstem response is beneficial to understand how speech sounds are encoded within the brainstem region in hearing-impaired children, as well as in those with compromised neural function. In this book, we have gathered research from Malaysia and India in this field and hope it will be of interest to our readers"--
Epigenetics In Health And Disease
DOWNLOAD
Author : Igor Kovalchuk
language : en
Publisher: FT Press
Release Date : 2012
Epigenetics In Health And Disease written by Igor Kovalchuk and has been published by FT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Juvenile Nonfiction categories.
"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Page 4 of cover.
Genomic Imprinting And Kinship
DOWNLOAD
Author : David Haig
language : en
Publisher: Rutgers University Press
Release Date : 2002
Genomic Imprinting And Kinship written by David Haig and has been published by Rutgers University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Science categories.
Genomic imprinting allows scientists to trace genes to the parent of origin. This volume presents a collection of 13 papers by David Haig (organisimic and evolutionary biology, Harvard U.) on genomic imprinting. He argues that our paternally and maternally active genes do not work in cooperation with each other and in fact are in competition. Each paper is followed by commentary by the author, providing background information and discussing developments since its publication. Annotation copyrighted by Book News Inc., Portland, OR.
The Imprinted Brain
DOWNLOAD
Author : Christopher Badcock
language : en
Publisher: Jessica Kingsley Publishers
Release Date : 2009-05-15
The Imprinted Brain written by Christopher Badcock and has been published by Jessica Kingsley Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-15 with Psychology categories.
The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism. Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis. This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
Evidence Based Practice Toward Optimizing Clinical Outcomes
DOWNLOAD
Author : Xenia Maria Caldeira Brant
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-17
Evidence Based Practice Toward Optimizing Clinical Outcomes written by Xenia Maria Caldeira Brant and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-17 with Medical categories.
Health care is witnessing an explosion of fundamental, clinical and translational research evidence. The emerging paradigm of evidence-based health care rests on the judicious integration of the patient needs/wants, the provider's expertise, and the best available research evidence in the treatment plan. The purpose of this book is to discuss the promise and the limitations of incorporating the best available evidence in clinical practice. It seeks to characterize and define how best available research evidence can be used in clinical practice and to what respect it applies to current public health issues.
Epigenetics And Human Health
DOWNLOAD
Author : Alexander Haslberger
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-21
Epigenetics And Human Health written by Alexander Haslberger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-21 with Science categories.
After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.
Chromatin Structure And Gene Expression
DOWNLOAD
Author : Sarah C. R. Elgin
language : en
Publisher: Frontiers in Molecular Biology
Release Date : 2000
Chromatin Structure And Gene Expression written by Sarah C. R. Elgin and has been published by Frontiers in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Chromatin categories.
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.