Zoonotic Diseases Epidemiology Multi Omics And Host Pathogen Interactions

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Zoonotic Diseases Epidemiology Multi Omics And Host Pathogen Interactions

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Author : Lei Deng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-21

Zoonotic Diseases Epidemiology Multi Omics And Host Pathogen Interactions written by Lei Deng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-21 with Science categories.

Zoonotic diseases are infections that can be transmitted between people and animals. These infections are caused by microorganisms, such as viruses, bacteria, parasites, and fungi. Patients with zoonotic infections can experience severe and life-threatening illness, whilst others remain asymptomatic. For example, animals can harbor germs asymptomatically for long periods with no apparent impact on their own health. However, some microbes carried by animals can result in human illness, depending on the zoonotic disease. Furthermore, it is widely reported that almost 60% of human diseases are zoonotic, and at least 75% of the pathogens that cause diseases in humans are of zoonotic origin.

Current Trends In Wildlife Research

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Author : Rafael Mateo
language : en
Publisher: Springer
Release Date : 2016-04-25

Current Trends In Wildlife Research written by Rafael Mateo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-25 with Science categories.

This book, the first in the “Wildlife Research Monograph” series, defines “wildlife research” in a variety of contexts and reviews recent research trends. The authors present the current developments they have identified using bibliometric analyses of the most common, relevant and emerging topics in wildlife research over the last three decades. Diverse aspects of wildlife research are discussed, including wildlife demography, infections spread between wildlife, livestock and humans, habitat requirements and management, as well as the effects of renewable energy and pollutants on wildlife. Furthermore the authors explore topics like advances in the study of species distribution, invasive species, use of molecular markers in wildlife studies and the sustainability of wildlife exploitation and conservation conflicts. The book offers a comprehensive overview of advances in wildlife research in the last decades.

Drug Discovery And One Health Approach In Combating Infectious Diseases

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Author : Kanti Bhooshan Pandey
language : en
Publisher: Elsevier
Release Date : 2025-08-01

Drug Discovery And One Health Approach In Combating Infectious Diseases written by Kanti Bhooshan Pandey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-01 with Science categories.

Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases. - Presents practical case studies on successful One Health initiatives - Covers the fundamentals of drug discovery and the One Health Approach through an interdisciplinary lens - Explains innovative technologies and emerging trends in infectious disease management and drug discovery

Host Pathogen Interactions During Arboviral Infections

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Author : Alan G. Goodman
language : en
Publisher: Frontiers Media SA
Release Date : 2019-07-19

Host Pathogen Interactions During Arboviral Infections written by Alan G. Goodman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-19 with categories.

Arboviruses, or arthropod-borne viruses, such as West Nile virus, Dengue virus, and Zika virus, pose a serious threat to public health worldwide. West Nile virus was introduced to the United States in 1999, and is now endemic, causing over 2,000 domestically acquired cases in the U.S. annually in mammals. Similarly, dengue and Zika viruses are endemic in the Americas and pose novel threats to the human population. Tick-borne viruses such as Powassan virus and Heartland virus are increasing in frequency in the U.S. At this time, there is no commercially available vaccine or therapeutic to treat these viral infections. Because nearly every mammalian case of these virus infections originates from the insect vector, it is imperative that we also understand viral pathogenesis, transmission, and the immune response in insect models as well as pathogenesis and the host responses in infected mammals. The development of methods to block arbovirus transmission from the vector may be effective at ceasing arthropod-to-human infection since the current recommendation to prevent these viral infections is to decrease contact with mosquitoes. Additionally, improving our understanding of epidemiology and ecology will also help develop measures to reduce virus spread. In order to better study mammalian and insect host responses to infection, a number of genetic tools are available, such as fly, mosquito, and tick models, recombinant viruses, mouse models, and bioinformatics tools. The studies described in this eBook will illustrate host responses to infection using mammalian and insect models, identify critical signaling nodes of the innate immune response, and discuss virus transmission from insect to mammal or among infected hosts. Taken together, these studies will elucidate means of decreasing infections in human populations and provide potential targets for future study and therapeutic design.

Tick Host Pathogen Interactions

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Author : Sarah Irène Bonnet
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-24

Tick Host Pathogen Interactions written by Sarah Irène Bonnet and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-24 with categories.

Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.

Proteomics Of Microbial Human Pathogens

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Author : Nelson C. Soares
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-17

Proteomics Of Microbial Human Pathogens written by Nelson C. Soares and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-17 with categories.

According to the World Health Organization (WHO), in 2012 infectious diseases and related conditions account for more than 70% of premature deaths across 22 African countries and estimated 450 000 people worldwide developed multi-drug resistant tuberculosis. This alarming situation, of great public health concern, calls for the urgent development of novel and efficient responding strategies. The employment of important research platforms, such as genomics and proteomics, has contributed significant insight into the mechanisms underlying microbial infection and microbe-host interaction. In this Frontiers Research Topic, we aim to produce a timely and pertinent discussion regarding the current status of “Proteomics of microbial Human pathogens” and the role of proteomics in combating the challenges posed by microbial infection and indeed acquired anti-microbial resistance. As the field of proteomics progressed from 2-DE gel based approaches to modern LC-MS/MS based workflows, remarkable advances have been reported in terms of data quantity and quality. Given the immediate and enormous advantages that high resolution and accurate mass spectrometers have brought to the field, proteomics has now evolved into a robust platform capable of generating large amounts of comprehensive data comparable to that reported previously in genomics studies. For example, detection of the complete yeast proteome has been reported and other small proteomes, such as those of bacteria, are within reach. Mass spectrometry-based proteomics has become an essential tool for biologists and biochemists, and is now considered by many as an essential component of modern structural biology. Additionally, the introduction of high-resolution mass spectrometers has driven the development of various different strategies aimed at accurate quantification of absolute and relative amount of protein(s) of interest. Emerging targeted mass spectrometry methodologies such as; Selected Reaction Monitoring (SRM), Parallel Reaction Monitoring (PRM) and SWATH, are perhaps the latest breakthrough within the proteomics community. Indeed, through a label free approach, targeted mass spectrometry offers an unequalled capability to characterize and quantify a specific set of proteins reproducibility, in any biological sample. Usefully, Aebersold and colleagues have recently generated and validated a number of assays to quantify 97% of the 4,012 annotated Mycobacterium tuberculosis (Mtb) proteins by SRM. As such, the Mtb Proteome library represents a valuable experimental resource that will undoubtedly bring new insight to the complex life cycle of Mtb. Finally, as reviewed recently in Frontiers Research Topic, mass spectrometry-based proteomics has had a tremendous impact on our current understanding of post translational modification (PTM) in bacteria including the key role of PTMs during interaction of pathogenic bacteria and host interactions. We believe that our understanding of microbial Human pathogens has benefited enormously from both 2-DE gel and modern LC-MS/MS based proteomics. It is our wish to produce an integrated discussion surrounding this topic to highlight the existing synergy between these research fields. We envisage this Research Topic as a window to expert opinions and perspectives on the realistic practicalities of proteomics as an important tool to address healthcare problems caused by microbial pathogens.

Molecular Medical Microbiology

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Author : Yi-Wei Tang
language : en
Publisher: Academic Press
Release Date : 2023-11-21

Molecular Medical Microbiology written by Yi-Wei Tang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-21 with Science categories.

Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. - Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology - Includes full color presentations throughout - Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach - Includes a clinical overview for each major bacterial group - Presents the latest information on vaccine development, molecular technology and diagnostic technology - Provides more than 100 chapters on all major groups of bacteria

Omics Approaches In Veterinary Parasitology

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Author : Muhammad Sohail Sajid
language : en
Publisher: CRC Press
Release Date : 2024-11-28

Omics Approaches In Veterinary Parasitology written by Muhammad Sohail Sajid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-28 with Medical categories.

Omics Approaches in Veterinary Parasitology: Diagnosis, Biomarkers, and Drug Development explores applications of omics approaches for diagnosis, biomarker discovery, and drug development against parasites of veterinary importance. It presents the fundamental principles of parasite biology and their complex physiological processes. The chapters review key aspects such as parasite life cycles, host-parasite interactions, and the molecular mechanisms that underlie parasitic diseases. The subsequent chapters delve into the principles and applications of genomics, transcriptomics, proteomics, and metabolomics in understanding parasites at a molecular level. The use of next-generation sequencing, PCR-based assays, and metagenomics in identifying and characterizing parasites for accurate and efficient diagnosis are also covered in detail. Toward the end, the book focuses on target identification, drug repurposing, and the optimization of drug efficacy while minimizing drug resistance using omics data. The book is useful for researchers, students, and professionals in the field of veterinary parasitology.

Microbiome And Machine Learning

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Author : Isabel Moreno Indias
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-02

Microbiome And Machine Learning written by Isabel Moreno Indias and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-02 with Science categories.

The Biology And Ecology Of Ticks Shape The Potential For The Transmission Of Zoonotic Pathogens

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Author : Agustín Estrada-Peña
language : en
Publisher: Frontiers Media SA
Release Date : 2015-02-24

The Biology And Ecology Of Ticks Shape The Potential For The Transmission Of Zoonotic Pathogens written by Agustín Estrada-Peña and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-24 with Infectious and parasitic diseases categories.

Ticks are noticeable by the high diversity of pathogens they can transmit, most of them with implications in human and animal health. Ticks are arachnids, meaning that they do not share the biological and ecological features of the mosquitoes and other parasitic Diptera. The natural foci of tick-borne pathogens may be as large as a continent, or be restricted to small portions of a country, without apparently too many similar features. The life cycle of the ticks involved three developing instars. The precise relationships of ticks and their hosts, the specific seasonal pattern of activity of ticks, and the still poorly known molecular relationships between ticks and the pathogens they can transmit, make these vectors a specially fecund field of research. Importantly, extensive studies on the biological and ecological relationships of ticks and abiotic (climate and vegetation) conditions have revealed the fine-tuning of the ticks and the pathogens they transmit, together with the biological effects of host and the driving features by the climate. The studies on tick-transmitted pathogens have been on the rise in the last years. There is a growing interest in understand the somewhat complex relationships between the landscape, the climate, the vectors and the pathogens, because the concerns of spread, probably driven by subtle changes in climate and man made alterations of the landscape. Studies on Lyme borreliosis are addressing the interesting issue of the relationships between the climate, the tick activity patterns, and the selection of strains according to the reservoir availability. Furthermore, the expanding field of habitat suitability modeling has been applied with different degrees of success to evaluate and quantify the risk of disease transmission. In such exponentially growing field, revisionary books are clearly welcome additions to the bibliographical tools of researchers. It is however necessary the compilation of works devoted to explore the tip of the iceberg in the field of research. In this Research Topic, we wish to summarize and review the studies on ecology, molecular biology, and tick-host-pathogens interactions, provided to resolve the important issues of ticks and pathogens. We want not only the results obtained by newly developed molecular tools, but rigorous reviews of the most recent advances in these issues. This Topic will cover aspects of both human and animal health, with special interest on zoonoses. Aspects of the biology of the ticks, as affecting the transmission of pathogens, are of special interest in this Topic. Studies on ticks of the poorly known family Argasidae, as related to their involvement on pathogen transmission, are especially welcome. We also wish to describe the perspective of the field in the future. Finally, the presentation of ongoing original works is greatly encouraged.