Cell Motility In Cancer Invasion And Metastasis
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Cell Motility In Cancer Invasion And Metastasis
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Author : Alan Wells
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-22
Cell Motility In Cancer Invasion And Metastasis written by Alan Wells and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-22 with Medical categories.
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Mechanisms Of Invasion And Metastasis
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Author : Marc M. Mareel
language : en
Publisher: CRC Press
Release Date : 1991-04-23
Mechanisms Of Invasion And Metastasis written by Marc M. Mareel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-04-23 with Medical categories.
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
Cell Motility And Cancer
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Author : José I López
language : en
Publisher: Mdpi AG
Release Date : 2021-10-29
Cell Motility And Cancer written by José I López and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
This Special Issue is conceived as a forum for basic, translational, and clinical research related to cell directional motility mechanisms and tumor cell migration. Under such a generic umbrella, basic researchers in biology, systems biology, and other quantitative sciences, as well as in physiology and pharmacology, will have the opportunity to join clinical specialties in medical oncology, biochemistry, immunology, and pathology. Such unique convergence of disciplines will enrich the panorama of a central characteristic of malignant tumors' cell motility.
Cell Migration
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Author : Frank Entschladen
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010
Cell Migration written by Frank Entschladen and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.
Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
Actin Cytoskeleton In Cancer Progression And Metastasis Part C
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-05-04
Actin Cytoskeleton In Cancer Progression And Metastasis Part C written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Science categories.
Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Cancer Metastasis
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Author : Yasemin Basbinar
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-12-05
Cancer Metastasis written by Yasemin Basbinar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-05 with Medical categories.
Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.
Signal Transduction In Cancer Metastasis
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Author : Wen-Sheng Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-04
Signal Transduction In Cancer Metastasis written by Wen-Sheng Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-04 with Medical categories.
This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.
Signaling Pathways And Molecular Mediators In Metastasis
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Author : Alessandro Fatatis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-03
Signaling Pathways And Molecular Mediators In Metastasis written by Alessandro Fatatis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-03 with Medical categories.
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
New Developments In Metastasis Suppressor Research
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Author : Paul Jackson
language : en
Publisher: Nova Publishers
Release Date : 2007
New Developments In Metastasis Suppressor Research written by Paul Jackson and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Antioncogenes categories.
The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.
Cell Invasion
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Author : Jyrki Heino
language : en
Publisher: CRC Press
Release Date : 2002-08-01
Cell Invasion written by Jyrki Heino and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-01 with Science categories.
Provides an overview of cell invasion. Topics include information on the cellular matrix, cell surface integrins, matrix metalloproteinases and proteinases, and the interplay between protein families.