Cell Motility In Cancer Invasion And Metastasis
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Cell Motility In Cancer Invasion And Metastasis
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Author : Alan Wells
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-02-02
Cell Motility In Cancer Invasion And Metastasis written by Alan Wells and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-02 with Medical categories.
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Cell Motility And Cancer
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Author : José I López
language : en
Publisher: Mdpi AG
Release Date : 2021-10-29
Cell Motility And Cancer written by José I López and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
This Special Issue is conceived as a forum for basic, translational, and clinical research related to cell directional motility mechanisms and tumor cell migration. Under such a generic umbrella, basic researchers in biology, systems biology, and other quantitative sciences, as well as in physiology and pharmacology, will have the opportunity to join clinical specialties in medical oncology, biochemistry, immunology, and pathology. Such unique convergence of disciplines will enrich the panorama of a central characteristic of malignant tumors' cell motility.
Cytoskeleton
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Author : Jose C. Jimenez-Lopez
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-05-17
Cytoskeleton written by Jose C. Jimenez-Lopez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-17 with Science categories.
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Tumor Metastasis
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Author : Ke Xu
language : en
Publisher: Intechopen
Release Date : 2016-09-14
Tumor Metastasis written by Ke Xu and has been published by Intechopen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-14 with Medical categories.
The key aim of the proposed chapter is to provide readers a brief description for the most important parts of the field of circulating tumor cells (CTCs): the core techniques, including negative and positive selection-based CTC isolation, and the differences between them. Most importantly, we will also review the clinical applications and important findings in clinical trials. The evidence-based review will not only help clinicians use CTCs to predict recurrence and foresee the disease-related outcomes but also to inspire the researchers in this field to conduct further investigations.
Metastatic Cancer Clinical And Biological Perspectives
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Author : Rahul Jandial
language : en
Publisher: CRC Press
Release Date : 2013-08-08
Metastatic Cancer Clinical And Biological Perspectives written by Rahul Jandial and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-08 with Medical categories.
Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Physics Of Cancer
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Author : Claudia Tanja Mierke
language : en
Publisher:
Release Date : 2018
Physics Of Cancer written by Claudia Tanja Mierke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biophysics categories.
"In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer. This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion" -- Prové de l'editor.
Cancer Metastasis
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Author : Yasemin Basbinar
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-12-05
Cancer Metastasis written by Yasemin Basbinar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-05 with Medical categories.
Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.
The Biology Of Cancer
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Author : Weinberg, Robert A.
language : en
Publisher: W.W. Norton & Company
Release Date : 2013-05-24
The Biology Of Cancer written by Weinberg, Robert A. and has been published by W.W. Norton & Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-24 with Science categories.
Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.
Introduction To Cancer Metastasis
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Author : Aamir Ahmad
language : en
Publisher: Academic Press
Release Date : 2016-11-14
Introduction To Cancer Metastasis written by Aamir Ahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Medical categories.
Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. - Includes basic biology and translational approaches to organ-specific cancer sites - Provides readers with information on emerging therapeutic targets for cancer metastasis - Contains contributions from leading researchers around the globe
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention
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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.