A L S

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Amyotrophic Lateral Sclerosis

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Author : Hiroshi Mitsumoto
language : en
Publisher: Oxford University Press, USA
Release Date : 1998-01-02

Amyotrophic Lateral Sclerosis written by Hiroshi Mitsumoto and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-02 with Medical categories.

Amyotrophic Lateral Sclerosis presents the most comprehensive, clinically-focused information on ALS (Lou Gehrig's disease) in print. The three authors, widely known for their work in this area, provide cohesive and balanced coverage of this syndrome, including the history, clinical features, pathology and pathogenesis, treatment and management of ALS. To facilitate understanding, each chapter is enhanced by comprehensive tables and figures, as well as detailed chapter summaries.

Understanding The Als Pathogenesis Therapeutic Approaches In Context With Mesenchymal Stem Cells And Extracellular Vesicles An Overview

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Author : Dr.Hakim Saboowala
language : en
Publisher: Dr.Hakim Saboowala
Release Date : 2020-04-22

Understanding The Als Pathogenesis Therapeutic Approaches In Context With Mesenchymal Stem Cells And Extracellular Vesicles An Overview written by Dr.Hakim Saboowala and has been published by Dr.Hakim Saboowala this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-22 with Medical categories.

Understanding the ALS Pathogenesis & Therapeutic Approaches in context with Mesenchymal Stem Cells and Extracellular Vesicles. An Overview.  Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle paralysis determined by the degeneration of motoneurons in the motor cortex brainstem and spinal cord. The ALS pathogenetic mechanisms are still unclear, despite the wealth of studies demonstrating the involvement of several altered signaling pathways, such as: · Mitochondrial dysfunction, · Glutamate excitotoxicity, · Oxidative stress and · Neuroinflammation. To date, the proposed therapeutic strategies are targeted to one or a few of these alterations, resulting in only a minimal effect on disease course and survival of ALS patients. The involvement of different mechanisms in ALS pathogenesis underlines the need for a therapeutic approach targeted to multiple aspects. Ø Mesenchymal stem cells (MSC) can: o Support motoneurons and surrounding cells, o Reduce inflammation, o Stimulate tissue regeneration and o Release growth factors. · On this basis, MSC have been proposed as promising candidates to treat ALS. However, due to the drawbacks of cell therapy, the possible therapeutic use of extracellular vesicles (EVs) released by stem cells is raising increasing interest. An attempt has been made as usual in this informative E-Booklet to summarize the main pathological mechanisms involved in ALS and the related therapeutic approaches proposed to date, focusing on Mesenchymal stem cells (MSC) therapy and their pre-clinical and clinical applications. Moreover, how and why the extracellular vesicles (EVs) could provide novel opportunities for ALS treatment has been elucidated along with several relevant illustrations and Transmission Microscopic views. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London).

Inhibitory Dysfunction In The Sod1 Als Motor Cortex

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Author : Charline Sahara Khademullah
language : en
Publisher:
Release Date : 2018

Inhibitory Dysfunction In The Sod1 Als Motor Cortex written by Charline Sahara Khademullah and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of the motor system, typically affecting individuals over 60 years of age (Eisen et al. 1993; Brettschneider, Kurent, and Ludolph 2013). It results from motor neuron degeneration in the cortex and spinal cord and is characterized by catastrophic muscle weakness and atrophy that eventually spreads across the body as it progresses into later stages (Kiernan et al. 2011). Without any effective treatments available, ALS is 100% fatal with a median survival of 3 years following the onset of physiological symptoms (Talbot 2009, 2014). Recent studies on cortical dysfunction in ALS have reported anomalies in inhibitory synaptic transmission; however, little is known regarding the role of inhibition in ALS. Sufficient GABAergic inhibitory neurotransmission is not only critical for maintaining a balance between excitation and inhibition, but it is also capable of providing protective effects from excitatory motor neurons in the cortex (Bae et al. 2013). Thus, it is critical to understand how inhibition is affected in ALS and whether the inhibitory circuit can be manipulated to alter the outcome of the disease. The main objective of my PhD project was to determine if parvalbumin-positive (PV+) interneurons in layer 5 (L5) of the primary motor cortex (M1) regulate the pyramidal cell hyperexcitability in the SOD1G93A mouse model of ALS, which has been tightly linked to excitotoxic cell death (Foran and Trotti 2009; Bae et al. 2013). Additionally, using newly developed chemogenetic tools, I aimed to increase PV+-interneuron activity with the goal of reducing pyramidal cell hyperexcitability and delay the onset of ALS-associated symptoms. The principle novel discoveries from my thesis research are: (i) PV+ interneurons are hypoactive in the pre-symptomatic SOD1G93A mouse model of ALS; (ii) increasing PV+ interneuron-mediated inhibition onto L5-M1 pyramidal cells not only rescues M1 pyramidal cell hyperexcitability, it also delays the onset of ALS-associated motor deficits, preserves cortical neuronal populations, and significantly increases the lifespan of SOD1G93A mice; and (iii) tissues from the motor cortex of post-mortem SOD1-ALS patients and SOD1G93A mice show a marked decrease in key inhibitory proteins known to regulate inhibitory function.

Navigating Life With Amyotrophic Lateral Sclerosis

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Author : Mark B. Bromberg
language : en
Publisher: Oxford University Press
Release Date : 2017

Navigating Life With Amyotrophic Lateral Sclerosis written by Mark B. Bromberg and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.

Navigating Life with Amyotrophic Lateral Sclerosis provides accessible, comprehensive, and up-to-date information about the challenges patients, family members, and caregivers face when confronted by ALS, a disease that affects approximately 5,600 Americans every year, with as many as 30,000 people managing the disease at any given time. ALS is a difficult disease for the patient and is also challenging for the caregiver and family as there are many questions, issues relating to care, and problems to manage. This guide covers all aspects of managing ALS, from the onset of symptoms, diagnosis, treatments, and coping strategies, to the use of home health care or hospice, and new research in the field. The book also sheds lights on difficult topics, such as end-of-life care and managing legal affairs. Navigating Life with Amyotrophic Lateral Sclerosis is unique because it covers two perspectives: one author is a neurologist with 30 years of experience treating ALS patients, and the other author experienced first-hand the issues in providing care for a parent with ALS. Formatted in a question-and-answer style, peppered throughout with patient stories, and with sections devoted to family members and caregivers, this compassionate resource provides guidance to those seeking to understand how to live with this disease.

Amyotrophic Lateral Sclerosis

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Author : Tadao Tsubaki
language : en
Publisher:
Release Date : 1979

Amyotrophic Lateral Sclerosis written by Tadao Tsubaki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.

Treating Als With Quality Of Life In Low Income Urban Patient Populations

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Author : Lydia Q. Kauffman
language : en
Publisher:
Release Date : 2021

Treating Als With Quality Of Life In Low Income Urban Patient Populations written by Lydia Q. Kauffman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

Amyotrophic Lateral Sclerosis is a neurodegenerative disease affecting adults with disease onset averaging between 50-60 years of age. As neurons die, patients experience rapid physical and cognitive decline with death typically following 3-5 years after diagnosis. As there is currently no cure for disease and no treatment to prolong life expectancy, medical management is focused on quality of life. In addition to traditional medical treatments, medical professionals must also consider maximizing autonomy as a way to increase quality of life with a focus on relational and psychological factors. For patients in low-income urban neighborhoods, inequalities affecting agency should be evaluated as part of medical care to increase both autonomy and overall quality of life.

Palliative Care In Amyotrophic Lateral Sclerosis

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Author : David Oliver
language : en
Publisher: Oxford University Press (UK)
Release Date : 2014

Palliative Care In Amyotrophic Lateral Sclerosis written by David Oliver and has been published by Oxford University Press (UK) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.

This volume provides an evidence-based guide to the care of people with ALS/MND, including the control of symptoms, the psychosocial care of patients and their families, and care in bereavement.

Fast Facts Diagnosing Amyotrophic Lateral Sclerosis

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Author : Martin Turner
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2019-11-26

Fast Facts Diagnosing Amyotrophic Lateral Sclerosis written by Martin Turner and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-26 with Medical categories.

A diagnosis of amyotrophic lateral sclerosis (also known as Lou Gehrig's disease or motor neuron disease) is a progressive neurodegenerative disorder that exerts a notorious life-shortening physical toll. Understandably, clinicians are keen to avoid a wrong diagnosis when there are such serious consequences, but any delay in diagnosis can result in unnecessary, and sometimes harmful, interventions, and prevents prompt implementation of much-needed physical and emotional support. Starting from the premise that ALS is not one disease but a syndrome, with a spectrum of upper and lower motor neuron involvement, this highly readable resource examines the causes of diagnostic delay and how to avoid them. With no diagnostic test to confirm the disease, no mandatory investigations and very few plausible 'ALS mimics', the authors take a pragmatic approach to what must always be a clinical diagnosis. With case presentations and teaching points to aid understanding, 'Fast Facts: ALS' will give clinicians the confidence to confirm or exclude a diagnosis of ALS, so that individuals facing this most challenging of conditions can receive rapid multidisciplinary support to maximize the quality of their remaining life. Contents: • Defining the syndrome • Epidemiology and pathophysiology • The first symptoms • Differential diagnosis • Investigations • Emerging diagnostic biomarkers

A Guide To Als Patient Care For Primary Care Physicians

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Author :
language : en
Publisher:
Release Date : 2010*

A Guide To Als Patient Care For Primary Care Physicians written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010* with categories.

Living With Als

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Author :
language : en
Publisher:
Release Date : 2007

Living With Als written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Amyotrophic lateral sclerosis categories.