A Mathematical Approach To Multilevel Multiscale Health Interventions
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A Mathematical Approach To Multilevel Multiscale Health Interventions
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Author : Rodrick Wallace
language : en
Publisher: World Scientific
Release Date : 2013
A Mathematical Approach To Multilevel Multiscale Health Interventions written by Rodrick Wallace and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Business & Economics categories.
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule OC magic bulletOCO interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States OCo from $200 million in 1950 to $1.2 billion in 2010 OCo has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of OC magic bulletsOCO, we must now apply OC magic strategiesOCO that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies."
Mathematical Approach To Multilevel Multiscale Health Interventions A Pharmaceutical Industry Decline And Policy Response
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Author : Rodrick Wallace
language : en
Publisher: World Scientific
Release Date : 2013-01-28
Mathematical Approach To Multilevel Multiscale Health Interventions A Pharmaceutical Industry Decline And Policy Response written by Rodrick Wallace and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-28 with Mathematics categories.
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies./a
Computational Psychiatry
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Author : Rodrick Wallace
language : en
Publisher: Springer
Release Date : 2017-04-20
Computational Psychiatry written by Rodrick Wallace and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-20 with Science categories.
This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.
Introducing The Oscillations Based Paradigm
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Author : Darius Plikynas
language : en
Publisher: Springer
Release Date : 2016-06-16
Introducing The Oscillations Based Paradigm written by Darius Plikynas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-16 with Computers categories.
The book presents a conceptually novel oscillations based paradigm, the Oscillation-Based Multi-Agent System (OSIMAS), aimed at the modelling of agents and their systems as coherent, stylized, neurodynamic processes. This paradigm links emerging research domains via coherent neurodynamic oscillation based representations of the individual human mind and society (as a coherent collective mind) states. Thus, this multidisciplinary paradigm delivers an empirical and simulation research framework that provides a new way of modelling the complex dynamics of individual and collective mind states. This book addresses a conceptual problem – the lack of a multidisciplinary, connecting paradigm, which could link fragmented research in the fields of neuroscience, artificial intelligence (AI), multi-agent system (MAS) and the social network domains. The need for a common multidisciplinary research framework essentially arises because these fields share a common object of investigation and simulation, i.e., individual and collective human behavior. Although the fields of research mentioned above all approach this from different perspectives, their common object of investigation unites them. By putting the various pathways of research as they are interrelated into perspective, this book provides a philosophical underpinning, experimental background and modelling tools that the author anticipates will reveal new frontiers in multidisciplinary research. Fundamental investigation of the implicit oscillatory nature of agents’ mind states and social mediums in general can reveal some new ways of understanding the periodic and nonperiodic fluctuations taking place in real life. For example, via agent states-related diffusion properties, we could investigate complex economic phenomena like the spread of stock market crashes, currency crises, speculative oscillations (bubbles and crashes), social unrest, recessionary effects, sovereign defaults, etc. All these effects are closely associated with social fragility, which follows and is affected by cycles such as production, political, business and financial. Thus, the multidisciplinary OSIMAS paradigm can yield new knowledge and research perspectives, allowing for a better understanding of social agents and their social organization principles.
Gene Expression And Its Discontents
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Author : Rodrick Wallace
language : en
Publisher: Springer
Release Date : 2016-11-23
Gene Expression And Its Discontents written by Rodrick Wallace and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-23 with Medical categories.
This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
Genes Brains And Human Potential
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Author : Ken Richardson
language : en
Publisher: Columbia University Press
Release Date : 2017-03-21
Genes Brains And Human Potential written by Ken Richardson and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-21 with Science categories.
For countless generations people have been told that their potential as humans is limited and fundamentally unequal. The social order, they have been assured, is arranged by powers beyond their control. More recently the appeal has been to biology, specifically the genes, brain sciences, the concept of intelligence, and powerful new technologies. Reinforced through the authority of science and a growing belief in bio-determinism, the ordering of the many for the benefit of a few has become more entrenched. Yet scientists are now waking up to the influence of ideology on research and its interpretation. In Genes, Brains, and Human Potential, Ken Richardson illustrates how the ideology of human intelligence has infiltrated genetics, brain sciences, and psychology, flourishing in the vagueness of basic concepts, a shallow nature-versus-nurture debate, and the overhyped claims of reductionists. He shows how ideology, more than pure science, has come to dominate our institutions, especially education, encouraging fatalism about the development of human intelligence among individuals and societies. Genes, Brains, and Human Potential goes much further: building on work being done in molecular biology, epigenetics, dynamical systems, evolution theory, and complexity theory, it maps a fresh understanding of intelligence and the development of human potential. Concluding with an upbeat message for human possibilities, this synthesis of diverse perspectives will engender new conversations among students, researchers, and other interested readers.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 1990
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cancer categories.
Medical Image Computing And Computer Assisted Intervention Miccai 2014
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Author : Polina Golland
language : en
Publisher: Springer
Release Date : 2014-08-31
Medical Image Computing And Computer Assisted Intervention Miccai 2014 written by Polina Golland and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-31 with Computers categories.
The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 100 papers included in the first volume have been organized in the following topical sections: microstructure imaging; image reconstruction and enhancement; registration; segmentation; intervention planning and guidance; oncology; and optical imaging.
Research Anthology On Improving Medical Imaging Techniques For Analysis And Intervention
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Author : Management Association, Information Resources
language : en
Publisher: IGI Global
Release Date : 2022-09-09
Research Anthology On Improving Medical Imaging Techniques For Analysis And Intervention written by Management Association, Information Resources and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-09 with Medical categories.
Medical imaging provides medical professionals the unique ability to investigate and diagnose injuries and illnesses without being intrusive. With the surge of technological advancement in recent years, the practice of medical imaging has only been improved through these technologies and procedures. It is essential to examine these innovations in medical imaging to implement and improve the practice around the world. The Research Anthology on Improving Medical Imaging Techniques for Analysis and Intervention investigates and presents the recent innovations, procedures, and technologies implemented in medical imaging. Covering topics such as automatic detection, simulation in medical education, and neural networks, this major reference work is an excellent resource for radiologists, medical professionals, hospital administrators, medical educators and students, librarians, researchers, and academicians.
Xii Mediterranean Conference On Medical And Biological Engineering And Computing 2010
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Author : Nicolas Pallikarakis
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-28
Xii Mediterranean Conference On Medical And Biological Engineering And Computing 2010 written by Nicolas Pallikarakis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-28 with Technology & Engineering categories.
Over the past three decades, the exploding number of new technologies and applications introduced in medical practice, often powered by advances in biosignal processing and biomedical imaging, created an amazing account of new possibilities for diagnosis and therapy, but also raised major questions of appropriateness and safety. The accelerated development in this field, alongside with the promotion of electronic health care solutions, is often on the basis of an uncontrolled diffusion and use of medical technology. The emergence and use of medical devices is multiplied rapidly and today there exist more than one million different products available on the world market. Despite the fact that the rising cost of health care, partly resulting from the new emerging technological applications, forms the most serious and urgent problem for many governments today, another important concern is that of patient safety and user protection, issues that should never be compromised and expelled from the Biomedical Engineering research practice agenda.