A Mathematical Model For Photothermal Therapy Of Spherical Tumors

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A Mathematical Model For Photothermal Therapy Of Spherical Tumors

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Author : Ahmed Mostafa Abdelhady Ismaeel
language : en
Publisher:
Release Date : 2019

A Mathematical Model For Photothermal Therapy Of Spherical Tumors written by Ahmed Mostafa Abdelhady Ismaeel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biomedical engineering categories.

A Time Dependent Mathematical Model For Concentration Of Therapeutic Agents In Neoplasm

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Author : Malisa Sarntinoranont
language : en
Publisher:
Release Date : 1996

A Time Dependent Mathematical Model For Concentration Of Therapeutic Agents In Neoplasm written by Malisa Sarntinoranont and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

A Mathematical Model For Tumor Therapy With A Fusogenic Oncolytic Virus

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Author : Karly A. Jacobsen
language : en
Publisher:
Release Date : 2013

A Mathematical Model For Tumor Therapy With A Fusogenic Oncolytic Virus written by Karly A. Jacobsen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.

Oncolytic virotherapy is a tumor treatment which uses viruses to selectively target and destroy cancer cells. Clinical trials have demonstrated varying degrees of success for the therapy with limitations predominantly due to barriers to viral spread throughout the tumor and the immune response to the virus. Fusogenic viruses, capable of causing cell-to-cell fusion upon infection of a tumor cell, have shown promise in recent experimental studies. The fusion causes the formation of large, multinucleated syncytia which eventually leads to cell death. We formulate a partial differential equations model with a moving boundary to describe the treatment of a spherical tumor with a fusogenic oncolytic virus. Syncytia formation, lysis, budding and interstitial diffusion are incorporated as mechanisms of viral spread. The tumor cells move via advection; the tumor radius is a time-dependent variable. A proof is presented for existence and uniqueness of local solutions to the nonlinear hyperbolic-parabolic system. In a special case, the model is reduced to an ordinary differential equations system for which a global stability analysis is performed. This provides a prediction of success or failure of the treatment in terms of long-term behavior of the tumor radius. A numerical algorithm for the model is formulated. Simulations demonstrate convergence to spatially homogeneous solutions and exponential growth or decay of the tumor radius in various cases. Accuracy of the numerical method is confirmed by comparison with the predicted tumor growth rate.

Mathematical Modeling Of The Immune System In Homeostasis Infection And Disease

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Author : Gennady Bocharov
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-24

Mathematical Modeling Of The Immune System In Homeostasis Infection And Disease written by Gennady Bocharov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-24 with categories.

The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).

In Silico Approach Towards Magnetic Fluid Hyperthermia Of Cancer Treatment

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Author : Muhammad Suleman
language : en
Publisher: Elsevier
Release Date : 2023-02-28

In Silico Approach Towards Magnetic Fluid Hyperthermia Of Cancer Treatment written by Muhammad Suleman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-28 with Medical categories.

In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications. Includes the diversities of cancer treatment modalities for their eradication with minimum damage to surrounding normal tissue Addresses tumors of different organs including liver, brain and breast Deals with mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies Provides insights on how to use hyperthermia in cancer treatments in addition to other conventional types of treatments

Numerical And Analytical Methods In Electromagnetics

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Author : Hristos T. Anastassiu
language : en
Publisher: MDPI
Release Date : 2021-03-19

Numerical And Analytical Methods In Electromagnetics written by Hristos T. Anastassiu and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-19 with Technology & Engineering categories.

Like all branches of physics and engineering, electromagnetics relies on mathematical methods for modeling, simulation, and design procedures in all of its aspects (radiation, propagation, scattering, imaging, etc.). Originally, rigorous analytical techniques were the only machinery available to produce any useful results. In the 1960s and 1970s, emphasis was placed on asymptotic techniques, which produced approximations of the fields for very high frequencies when closed-form solutions were not feasible. Later, when computers demonstrated explosive progress, numerical techniques were utilized to develop approximate results of controllable accuracy for arbitrary geometries. In this Special Issue, the most recent advances in the aforementioned approaches are presented to illustrate the state-of-the-art mathematical techniques in electromagnetics.

Photoacoustic Imaging And Spectroscopy

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Author : Lihong V. Wang
language : en
Publisher: CRC Press
Release Date : 2017-12-19

Photoacoustic Imaging And Spectroscopy written by Lihong V. Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-19 with Science categories.

Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.

Bio Nanomedicine For Cancer Therapy

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Author : Flavia Fontana
language : en
Publisher: Springer Nature
Release Date : 2021-02-04

Bio Nanomedicine For Cancer Therapy written by Flavia Fontana and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-04 with Medical categories.

The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.

Head And Neck Cancer

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Author : Jacques Bernier
language : en
Publisher: Springer
Release Date : 2016-08-22

Head And Neck Cancer written by Jacques Bernier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-22 with Medical categories.

​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Cancer Nanotechnology

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Author : Stephen R. Grobmyer
language : en
Publisher: Humana Press
Release Date : 2010-03-16

Cancer Nanotechnology written by Stephen R. Grobmyer and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-16 with Medical categories.

Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular BiologyTM series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.