A Mixed Model Approach For Intent To Treat Analysis In Longitudinal Clinical Trials With Missing Values
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A Mixed Model Approach For Intent To Treat Analysis In Longitudinal Clinical Trials With Missing Values
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Author : Hrishikesh Chakraborty
language : en
Publisher: RTI Press
Release Date : 2009-02-28
A Mixed Model Approach For Intent To Treat Analysis In Longitudinal Clinical Trials With Missing Values written by Hrishikesh Chakraborty and has been published by RTI Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-28 with Computers categories.
Missing values and dropouts are common issues in longitudinal studies in all areas of medicine and public health. Intent-to-treat (ITT) analysis has become a widely accepted method for the analysis of controlled clinical trials. In most controlled clinical trials, some patients do not complete their intended followup according to the protocol for a variety of reasons; this problem generates missing values. Missing values lead to concern and confusion in identifying the ITT population, which makes the data analysis more complex and challenging. No adequate strategy exists for ITT analyses of longitudinal controlled clinical trial data with missing values. Several ad hoc strategies for dealing with missing values for an ITT analysis are common in the practice of controlled clinical trials. We performed a detailed investigation based on simulation studies to develop recommendations for this situation. We compared sizes (type I errors) and power between some popular ad hoc approaches and the linear mixed model approach under different missing value scenarios. Our results suggest that, for studies with a high percentage of missing values, the mixed model approach without any ad hoc imputation is more powerful than other options.
A Mixed Model Approach For Intent To Treat Analysis In Longitudinal Clinical Trials With Missing Values
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Author : Hrishikesh Chakraborty
language : en
Publisher:
Release Date : 2009
A Mixed Model Approach For Intent To Treat Analysis In Longitudinal Clinical Trials With Missing Values written by Hrishikesh Chakraborty and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Clinical trials categories.
Nursing And Health Interventions
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Author : Souraya Sidani
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-22
Nursing And Health Interventions written by Souraya Sidani and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-22 with Medical categories.
Nursing and Health Interventions covers the conceptual, empirical, and practical knowledge required for engaging in intervention research. This revised edition provides step-by-step guidance on the complex process of intervention development and methods for developing, delivering, evaluating and implementing intervention, supported by a wealth of examples. The text describes each essential aspect of intervention research, from generating an intervention theory, to procedures for adopting evidence-based interventions in practice. This second edition provides up-to-date coverage of intervention research and its impact on improving standards of care. Throughout the text, readers are provided with the foundational knowledge required for generating evidence that informs treatment decisions in practice, and choosing the best approaches for designing, delivering, evaluating and implementing interventions. A valuable ‘one-stop’ resource for students, researchers, and health professionals alike, this book: Covers the importance and issues of evidence-based healthcare practice, the role of theory in research in the intervention design and evaluation, and evaluation of effectiveness and implementation of interventions in a single volume Reviews the decision-making steps and the knowledge needed to inform decisions in research and practice Discusses the limitations of evidence derived from randomized controlled trials (RCTs) Written by leading experts in the field, Nursing and Health Interventions remains an invaluable resource for nursing and healthcare students, researchers, and health practitioners wanting to understand and apply intervention to improve the quality of care.
Cancer Disparities
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Author : Ronit Elk
language : en
Publisher: Springer Publishing Company
Release Date : 2012
Cancer Disparities written by Ronit Elk and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Health & Fitness categories.
There has been remarkable progress in understanding, preventing, detecting, diagnosing, and treating cancer, resulting in a reduction of cancer incidence and mortality in the United States. Despite this, the cancer burden varies considerably by race/ethnicity and socioeconomic status. Cancer incidence rates vary markedly between racial/ethnic groups, but even more startling are the differences in outcome across groups. Cancer Disparities: Causes and Evidence-Based Solutions helps readers understand the scope and causes of this inequity by providing a detailed analysis of the many factors that result in cancer disparities across the cancer continuum, including the role of race/ethnicity, socioeconomic status, access to and use of services, insurance status, geographic variables, and differences in treatment provided to patients. Further, it is the first book to describe evidence-based, concrete solutions that can be used to reduce or even eliminate cancer health disparities. Fifteen previously unpublished studies of interventions designed specifically to achieve health equality are described. These studies focus on contextually and culturally appropriate strategies to enhance cancer prevention, screening and early detection, treatment, symptom management, and quality of life in underserved populations.
Analyzing Longitudinal Clinical Trial Data
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Author : Craig Mallinckrodt
language : en
Publisher: CRC Press
Release Date : 2016-12-12
Analyzing Longitudinal Clinical Trial Data written by Craig Mallinckrodt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Mathematics categories.
Analyzing Longitudinal Clinical Trial Data: A Practical Guide provide practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine practice.?This book, with its example-oriented approach that includes numerous SAS and R code fragments, is an essential resource for statisticians and graduate students specializing in medical research. The authors provide clear descriptions of the relevant statistical theory and illustrate practical considerations for modeling longitudinal data. Topics covered include choice of endpoint and statistical test; modeling means and the correlations between repeated measurements; accounting for covariates; modeling categorical data; model verification; methods for incomplete (missing) data that includes the latest developments in sensitivity analyses, along with approaches for and issues in choosing estimands; and means for preventing missing data. Each chapter stands alone in its coverage of a topic. The concluding chapters provide detailed advice on how to integrate these independent topics into an over-arching study development process and statistical analysis plan.
Psychodynamic Interventions In Pregnancy And Infancy
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Author : Björn Salomonsson
language : en
Publisher: Routledge
Release Date : 2018-04-17
Psychodynamic Interventions In Pregnancy And Infancy written by Björn Salomonsson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-17 with Psychology categories.
Psychodynamic Interventions in Pregnancy and Infancy builds on Björn Salomonsson’s experiences as a psychoanalytic consultant working with parents and their babies. Emotional problems during the perinatal stages can arise and be observed and addressed by a skilled midwife, nurse or health visitor. Salomonsson has developed a method combining nurse supervision and therapeutic consultations which has lowered the thresholds for parents to come and talk with him. The brief consultations concern pregnant women, mother and baby, husband and wife, toddler and parent. The theoretical framework is psychoanalytic, but the mode of work is eclectic and adapted to the family’s situation and its members’ motivation. This book details such work, which can be applied globally; perinatal psychotherapy integrated with ordinary medical health care. It also explains how psychotherapy can be made more accessible to a larger population. Via detailed case presentations, the author takes the reader through pregnancy, childbirth and the first few years of life. He also brings in research studies emphasizing the importance of early interventions, with the aim of providing therapists with arguments for such work in everyday family health care. To further substantiate such arguments, the book ends with theoretical chapters and, finally, the author’s vision of the future of a perinatal health care that integrates medical and psychological perspectives. Psychodynamic Interventions in Pregnancy and Infancy will appeal to all psychoanalysts and psychoanalytic psychotherapists working in this area, as well as clinical psychologists, clinical social workers and medical personnel working with parents and infants.
Psychoanalytic Therapy With Infants And Their Parents
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Author : Björn Salomonsson
language : en
Publisher: Routledge
Release Date : 2014-04-24
Psychoanalytic Therapy With Infants And Their Parents written by Björn Salomonsson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-24 with Psychology categories.
Psychoanalytic Therapy with Infants and Parents provides a clear guide to clinical psychoanalytic work with distressed babies and unhappy parents, a numerous clinical group so often in need of urgent help. Although psychoanalytic work is primarily verbal, and infants may have limited language, this form of treatment is receiving increased attention among therapists. Björn Salomonsson explores how such work can be possible and benefit infants, how to work with the parents (especially the mother), and how major psychoanalytic concepts such as primal repression, infantile sexuality and transference can be worked with and understood in these therapies. Björn Salomonsson argues that attachment concepts, though important, cannot solely help explain everyday problems with breastfeeding, sleeping, and weaning, or more recalcitrant interaction disorders. He shows how we also need psychoanalytic concepts to better understand, not only such "baby worries", but also adult clients' non-verbal communications and interactions. Throughout, he uses extensive practice-based examples and also refers to his research which provides evidence for the effectiveness of this practice. Psychoanalytic Therapy with Infants and Parents provides a unique perspective on working psychoanalytically with parents and infants. This book will be essential reading for psychoanalysts and therapists working with children as well as adults.
Whole Body Electromyostimulation A Training Technology To Improve Health And Performance In Humans
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Author : Wolfgang Kemmler
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08
Whole Body Electromyostimulation A Training Technology To Improve Health And Performance In Humans written by Wolfgang Kemmler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.
Statistics For Advanced Practice Nurses And Health Professionals
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Author : Manfred Stommel, PhD
language : en
Publisher: Springer Publishing Company
Release Date : 2014-06-09
Statistics For Advanced Practice Nurses And Health Professionals written by Manfred Stommel, PhD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-09 with Medical categories.
This comprehensive, graduate-level text for advanced practice nurses and other health care professionals provides state-of-the-art tools that facilitate the reading and interpretation of clinical research articles that use increasingly complex statistical techniques. It addresses clinically relevant topics in biostatistics beyond the usual introduction to linear models, such as survival analysis and evaluation of screening tests. The text emphasizes the importance of understanding the underlying logic of statistical inference and statistical models to support correct interpretation and effective translation into practice. It promotes appropriate statistical method selection for conducting translational research. With a focus on disseminating information in easily understandable language, the text addresses basic statistical reasoning and four different classes of statistical models. The appendix provides refreshers on the algebraic underpinnings of statistics. More complex algebraic derivations are highlighted in boxes throughout the text chapters. The text explains how to work with the exponential expressions and logarithms necessary for the interpretation of logistic and hazard regression models and features clear explanations of more sophisticated statistical models, inference, and analyses. Chapters include examples from current research and multiple exercises designed to reinforce learning. Key Features: End-of-chapter exercises include both problems of interpretation and numerical problems that can be solved via hand calculations. For instructors and students interested in practical data analysis, data sets and practice problems are available from Springer Publishing Companyís website with instructions in SPSS, STATA, and SAS formats. At the end of each chapter is a ìLiterature Applicationî text box with interpretation questions about a recent research article that highlights the statistical model discussed in the chapter. Throughout the book, text boxes highlight the most important algebraic formulas useful in interpreting statistical methods. A chapter on data management practices and ethical issues of privacy maintenance is included. Nine appendices provide tables of major probability distributions, for example, normal, t- and F-distributions, and algebraic derivations of some of the most important results in statistics.
Clinical Trials In Neurology
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Author : Roberto J. Guiloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Clinical Trials In Neurology written by Roberto J. Guiloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.